Burkitt’s Lymphoma in Cuba

Riverend, Le; Rengifo, E.; Longchong, M.; Ruiz, Ryan Jose; Tormo, Beatriz; García, J.R.; Portero, Rosa Cano; Quintero, S.; M, Valdés; Rodriguez, Tulio E.; Ruisanchez, N; Gurtsevitch, Vladimir

doi:10.1159/000225783

Cited by 2 publications

(4 citation statements)

References 18 publications

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“…In sensitivity analyses, the highest EBV prevalence in patients with BL was observed when considering only case-control studies (67.6%; 95% CI: 58.0 to 76.5) [ 56 , 58 , 59 , 61 , 62 , 65 , 66 , 67 , 70 , 71 , 74 , 75 , 76 , 78 , 85 , 86 , 90 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 100 , 103 , 105 , 108 , 114 , 115 , 117 , 122 , 130 , 152 , 153 , 171 , 178 , 179 , 182 ], followed by considering only studies where the age was less than 18 years old (64.9%; 95% CI: 55.4 to 74.0) [ 56 , 58 , 59 , 61 , 62 , 63 , 69 , 70 , 72 , 73 ,…”

Section: Resultsmentioning

confidence: 99%

“…The ages of these patients ranged from 2.1 ± 2.5 to 47.7 ± 31.8 years (mean ± SD; range, 0.7-98.0). The studies came from eight different regions, and these region groupings were based on the geographic regions defined under the Standard Country or Area Codes for Statistical Use (known as M49) of the United Nations Statistics Division [55]: region unspecified (n = 414), Sub-Saharan Africa (n = 2104) , Northern Africa (n = 507) [91][92][93][94][95][96][97][98][99][100][101][102][103][104], Southern America (n = 801) [105][106][107][108][109][110][111][112][113][114][115][116][117][118][119][120][121][122], Southern Asia (n = 37) [123][124][125], Northern America (n = 201) [126][127][128][129][130][131][132][133][134][135]…”

Section: Study Characteristicsmentioning

confidence: 99%

“…In sensitivity analyses, the highest EBV prevalence in patients with BL was observed when considering only case-control studies (67.6%; 95% CI: 58.0 to 76.5) [56,58,59,61,62,65-67, 70,71,74-76,78,85,86,90,92-98,100,103,105,108,114,115,117,122,130,152,153,171,178,179,182], followed by considering only studies where the age was less than 18 years old (64.9%; 95% CI: 55.4 to 74.0) [56,58,59,[61][62][63]69,70,[72][73][74][75]77,78,81,89,90,94,95,98,99,[102][103][104][105][107][108][109][110]113,[115][116][117]120,122,126,135,137,138,163,165,166,169,174], excluding small studies with less than 100 subjects (64.0%; 95% CI: 40.3 to 84.9) [56,…”

Section: Heterogeneity and Sensitivity Analysismentioning

confidence: 99%

“…[65][66][67]70,71,73,76,[79][80][81]84,86,96,130,133,134,153,177,178], from 1983 to 1995[57,63,78,83,[93][94][95]100,101,109,111,112,122,[127][128][129]136,139,141,[143][144][145][146]148,151,[154][155][156]165,167,170,176,179,…”

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confidence: 99%

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Worldwide Prevalence of Epstein–Barr Virus in Patients with Burkitt Lymphoma: A Systematic Review and Meta-Analysis

et al. 2023

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Burkitt lymphoma (BL) is a form of B-cell malignancy that progresses aggressively and is most often seen in children. While Epstein–Barr virus (EBV) is a double-stranded DNA virus that has been linked to a variety of cancers, it can transform B lymphocytes into immortalized cells, as shown in BL. Therefore, the estimated prevalence of EBV in a population may assist in the prediction of whether this population has a high risk of increased BL cases. This systematic review and meta-analysis aimed to estimate the prevalence of Epstein–Barr virus in patients with Burkitt lymphoma. Using the appropriate keywords, four electronic databases were searched. The quality of the included studies was assessed using the Joanna Briggs Institute’s critical appraisal tool. The results were reported as percentages with a 95% confidence interval using a random-effects model (CI). PROSPERO was used to register the protocol (CRD42022372293), and 135 studies were included. The prevalence of Epstein–Barr virus in patients with Burkitt lymphoma was 57.5% (95% CI: 51.5 to 63.4, n = 4837). The sensitivity analyses demonstrated consistent results, and 65.2% of studies were of high quality. Egger’s test revealed that there was a significant publication bias. EBV was found in a significantly high proportion of BL patients (more than 50% of BL patients). This study recommends EBV testing as an alternative for predictions and the assessment of the clinical disease status of BL.

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Section: Resultsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

“…In sensitivity analyses, the highest EBV prevalence in patients with BL was observed when considering only case-control studies (67.6%; 95% CI: 58.0 to 76.5) [56,58,59,61,62,65-67, 70,71,74-76,78,85,86,90,92-98,100,103,105,108,114,115,117,122,130,152,153,171,178,179,182], followed by considering only studies where the age was less than 18 years old (64.9%; 95% CI: 55.4 to 74.0) [56,58,59,[61][62][63]69,70,[72][73][74][75]77,78,81,89,90,94,95,98,99,[102][103][104][105][107][108][109][110]113,[115][116][117]120,122,126,135,137,138,163,165,166,169,174], excluding small studies with less than 100 subjects (64.0%; 95% CI: 40.3 to 84.9) [56,…”

Section: Heterogeneity and Sensitivity Analysismentioning

confidence: 99%

mentioning

confidence: 99%

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Worldwide Prevalence of Epstein–Barr Virus in Patients with Burkitt Lymphoma: A Systematic Review and Meta-Analysis

et al. 2023

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Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED

Chabay

Lens

Hassan

et al. 2020

Cancers

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The Epstein–Barr virus (EBV), Kaposi sarcoma herpesvirus (KSHV) and human T-lymphotropic virus (HTLV-1) are lymphomagenic viruses with region-specific induced morbidity. The RIAL-CYTED aims to increase the knowledge of lymphoma in Latin America (LA), and, as such, we systematically analyzed the literature to better understand our risk for virus-induced lymphoma. We observed that high endemicity regions for certain lymphomas, e.g., Mexico and Peru, have a high incidence of EBV-positive lymphomas of T/NK cell origin. Peru also carries the highest frequency of EBV-positive classical Hodgkin lymphoma (HL) and EBV-positive diffuse large B cell lymphoma, not otherwise specified (NOS), than any other LA country. Adult T cell lymphoma is endemic to the North of Brazil and Chile. While only few cases of KSHV-positive lymphomas were found, in spite of the close correlation of Kaposi sarcoma and the prevalence of pathogenic types of KSHV. Both EBV-associated HL and Burkitt lymphoma mainly affect young children, unlike in developed countries, in which adolescents and young adults are the most affected, correlating with an early EBV seroconversion for LA population despite of lack of infectious mononucleosis symptoms. High endemicity of KSHV and HTLV infection was observed among Amerindian populations, with differences between Amazonian and Andean populations.

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Burkitt’s Lymphoma in Cuba

Cited by 2 publications

References 18 publications

Worldwide Prevalence of Epstein–Barr Virus in Patients with Burkitt Lymphoma: A Systematic Review and Meta-Analysis

Worldwide Prevalence of Epstein–Barr Virus in Patients with Burkitt Lymphoma: A Systematic Review and Meta-Analysis

Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED

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