Burkitt lymphoma in adults

Abstract

SummaryThe diagnosis of Burkitt Lymphoma (BL) and B‐cell lymphomas unclassifiable with features intermediate between Diffuse Large B‐cell Lymphoma and BL (BLU) in adults remains problematic even with immunophenotyping and MYC gene analysis. Gene expression profiling may improve categorization but is not routinely available. BL and its variants should be treated with specific regimens incorporating intensive courses of chemotherapy with fractionated alkylating agents and cell cycle phase‐specific agents that readily cross the blood brain barrier. Subsequent courses should be given as soon as haematological recovery occurs, with the whole course completed within a few months. A number of regimens have been developed that encompass these principles but there have been no comparative randomized trials. The results from several studies suggest that the addition of rituximab is highly efficacious and this may be particularly valuable in older patients. It is usual to employ ‘risk‐adapted’ strategies in the treatment of BL but these must be continually re‐evaluated, and ‘response‐adapted’ approaches should be explored. The role of transplantation is limited and largely confined to autologous transplants in patients who only achieve a partial response on front‐line therapy or who have a chemosensitive relapse. Further advances will be greatly facilitated by randomized trials, which will require international collaboration.

A unique bone marrow lymphoma patient presenting with an isolated mass: A case report

“…Lymphoma arising directly from bone marrow is not rare (2). Although arising from bone marrow, LBL, marginal zone lymphoma and Burkett lymphoma are not classified as PBML (2)(3)(4). Other types of lymphoma rarely originate from the bone marrow, including DLBCL and follicular lymphoma (10).…”

“…Some types of lymphoma originate directly from bone marrow. Lymphoblastic lymphoma (LBL), marginal zone lymphoma and Burkett lymphoma typically originate from bone marrow (2)(3)(4). LBL originates from immature precursor lymphocytes, it is highly invasive and divided into B cell LBL and T cell LBL, with the majority of LBL originating from precursor T cells (2,5,6).…”

Complete Remission of Burkitt Lymphoma After Surgical Excision: A Case Report

“…Thus for patients with BL who can tolerate aggressive therapies, intensive multiagent chemotherapy may offer the best chance for durable disease control. However BL is always fatal if left untreated [1,2].…”

Current approaches to lymphoma diagnosis

“…Заболевание чаще поражает органы брюш-ной полости: терминальный отдел тонкой кишки, толстую кишку и желудок. Поражение костного мозга при ЛБ встречается редко, за исключением ВИЧ-ассоциированной формы ЛБ [24].…”