Burkitt-Like Lymphoma Arising in the Thyroid Gland

Kandil, Emad; Noureldine, Salem I.; Khalek, Mohamed Abdel; Safah, Hana; Waddadar, Jay; Goswami, Monica; Friedlander, Paul

doi:10.1097/maj.0b013e318235af39

Cited by 8 publications

(8 citation statements)

References 15 publications

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“…The common histological subtypes are diffuse large B-cell lymphoma or mucosa-associated lymphoid tissue (MALT) lymphoma or a mixture of both [4–6]. Primary BL of the thyroid is very rare with a few isolated case reports in adult patients [7–10]. There are no published case-series of primary thyroid NHL in children and an extensive literature search only identified one previous case-report of primary BL of the thyroid [11].…”

Section: Discussionmentioning

confidence: 99%

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Burkitt Lymphoma of Thyroid Gland in an Adolescent

Cooper

Gangadharan

Arora

et al. 2014

Case Reports in Pediatrics

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Burkitt Lymphoma is a highly aggressive form of non-Hodgkin's lymphoma that in nonendemic areas has abdominal primary sites. We report a very rare case of Burkitt lymphoma of the thyroid gland presenting as a rapidly growing thyroid swelling in a 14-year-old white Caucasian British male with no preexisting thyroid or medical problems. The diagnosis was confirmed by an open wedge biopsy following a fine needle aspiration. The patient was treated according to the Children's Cancer and Leukaemia Group guidelines for BL—Group B protocol and currently is in remission.

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Section: Discussionmentioning

confidence: 99%

“…He had normal thyroid function tests and no metastatic spread. There are four previously reported cases in adults to date [9, 10, 18, 19]. Two of these adult cases presented due to the thyroid mass causing tracheal compression and thus airway compromise.…”

Section: Discussionmentioning

confidence: 99%

Burkitt Lymphoma of Thyroid Gland in an Adolescent

Cooper

Gangadharan

Arora

et al. 2014

Case Reports in Pediatrics

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“…This neoplasm is characterized by intermediate-sized lymphoid cells with a "starry sky" appearance and exhibits chromosomal translocations that activate the MYC oncogene [2,3]. To our knowledge, only 20 patients with primary thyroid BL have been described in the English-language literature [4][5][6][7][8][9][10][11][12][13][14][15][16]. Because of its extremely low prevalence, little is known about the pathogenesis and clinicopathological features of this disease, or about the differences between it and its systemic counterpart.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological features of primary thyroid Burkitt’s lymphoma: a systematic review and meta-analysis

et al. 2020

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Background: Primary thyroid Burkitt's lymphoma (BL) is an extremely rare and highly aggressive form of non-Hodgkin's lymphoma; only isolated case reports are available for patients with this disease. Methods: We analyzed the clinicopathological features of thyroid BL by conducting a meta-analysis of 21 known patients (including ours) and compared them to those of extrathyroidal BL. Results: There were 13 men and 8 women with a median age of 39.3 years (range, 6-75 years). The median followup was 46.5 months (range, 0.5-361 months). Six patients (28.6%) had stage I disease, 2 (9.5%) had stage II, 2 (9.5%) had stage III, and 11 (52.4%) had stage IV. Five of 7 tested patients with thyroid BL (71.4%) had histological evidence of underlying Hashimoto's thyroiditis. Ki-67 labeling indices exceeding 90% in all 19 patients tested (100%). Fluorescence in situ hybridization performed on 12 patient samples revealed that all (100%) had MYC rearrangement. Among the 16 patients for whom follow-up data were available, 4 died of disease-related causes. Kaplan-Meier analysis revealed that the 12-and 60-month overall survival rates for patients with thyroid BL were 87.5 and 70.7%, respectively. Conclusions: Ours was the largest study of thyroid BL and its detailed clinicopathological features to date. Thyroid BL is not associated with underlying Epstein-Barr virus infection but is closely linked to Hashimoto's thyroiditis; patients generally have good overall survival and respond well to intensive chemotherapy. The correct pathological diagnosis is essential for treatment selection and outcome improvement.

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“…The literature that we are aware of that reports the use of FC is listed in table 2[29,30,31,32,33,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58]. Two papers were case reports [48,54]; some included thyroid specimens in studies performed to assess the overall value of FNA in NHL diagnosis [29,30,32].…”

Section: Thyroid Lymphoproliferative Processesmentioning

confidence: 99%

“…6). BL, an exceptionally rare form of tumor in the thyroid [43], was suspected in a case where cytomorphology showed monotonous medium-sized lymphoid cells with scant cytoplasm, round nuclei and multiple nucleoli, where FC detected a high number of large B cells with increased CD10 expression. BL was confirmed by the subsequent incisional biopsy and molecular analysis, according to WHO criteria.…”

Section: Thyroid Lymphoproliferative Processesmentioning

confidence: 99%

Extranodal Lymphoproliferative Processes and Flow Cytometry

Stacchini¹,

Demurtas²,

Aliberti³

2016

Acta Cytologica

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Objective: Fine-needle aspiration (FNA) cytology is a safe and cost-effective technique for the diagnosis of lymphoproliferative processes, especially when correlated with clinical and imaging studies. However, cytology alone may be unable to detect a lymphoid neoplastic process, as architectural features are less obvious than in histologic preparations and, in certain cases, reactive processes may mimic lymphoma. Flow cytometry (FC) has been recognized as an important ancillary technique in the diagnosis of lymphoid neoplasms and it can be used in conjunction with FNA in the evaluation of lymphoproliferative processes. Study Design: We performed a review of the published literature concerning FC applied to the detection of salivary glands and thyroid lymphoproliferative processes, which are frequently related to autoimmune diseases and difficult to diagnose by cytomorphology alone. Results: FC is able to detect and subtype non-Hodgkin lymphomas and may contribute to the exclusion of a neoplastic process in cytologically unclear cases. Conclusions: FC can be successfully applied in the differential diagnosis of lymphoproliferative processes in the head and neck region. The FNA-FC combined approach can reduce time to therapy and may prevent unnecessary surgical biopsies.

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Burkitt-Like Lymphoma Arising in the Thyroid Gland

Cited by 8 publications

References 15 publications

Burkitt Lymphoma of Thyroid Gland in an Adolescent

Burkitt Lymphoma of Thyroid Gland in an Adolescent

Clinicopathological features of primary thyroid Burkitt’s lymphoma: a systematic review and meta-analysis

Extranodal Lymphoproliferative Processes and Flow Cytometry

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