Buriti pulp oil did not improve high‐fat diet‐induced metabolic disorders in c57bl/6 mice

Abstract

Metabolic syndrome (MetS) and obesity are growing in many parts of the world, becoming public health problems. It is proposed that foods with functional properties can assist in the treatment of these diseases. Crude buriti pulp oil (BPO) is a food traditionally consumed by residents in the Pantanal, Cerrado and Brazilian Amazon. It is rich in oleic acid, tocopherols and carotenoids, emerging as a potential functional food. Thus, this study aimed to evaluate the effect of the supplementation of BPO on metabolic disorders caused by a high‐fat diet. Four groups of C57BL6 mice were used, a lean group with AIN‐93M diet and control oil supplementation, an obese group with a high‐fat diet and control oil supplementation, and two obese groups with a high‐fat diet and BPO supplementation in the amounts of 50 and 100 mg/kg. BPO worsened the metabolic state caused by the high‐fat diet, worsening risk factors associated with MetS, as the abdominal circumference and retroperitoneal fat, serum levels of total cholesterol, uric acid, alanine transaminase, glucose and triglycerides, and renal fat, in addition to changes in glycaemic control and oxidative stress markers. C57BL/6 mice fed with a high‐fat diet and supplemented with BPO presented a worsening in metabolic risk factors associated with MetS.

Characterization of Buriti (Mauritia flexuosa) Pulp Oil and the Effect of Its Supplementation in an In Vivo Experimental Model

“…Among the analyzed groups, only the BO1 group presented an animal with steatosis >5%, with no association between the presence of steatosis and the experimental groups being observed (p = 0.41). In another study, the consumption of buriti oil at the highest dose (100 mg) also induced steatosis in the animals [67]. However, it was important that the animals in this study were obese, which may have contributed to the result (which was not observed in our animal study).…”