Burden of Migraine in Japan: Results of the ObserVational Survey of the Epidemiology, tReatment, and Care Of MigrainE (OVERCOME [Japan]) Study

Matsumori, Yasuhiko; Ueda, Kaname; Komori, Mika; Zagar, Anthony J.; Kim, Yongin; Jaffe, Dena H.; Takeshima, Takao; Hirata, Koichi

doi:10.1007/s40120-021-00305-9

Cited by 45 publications

(88 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings show that impact of migraine attacks, as measured by the HIT-6, migraine frequency and headache frequency were each uniquely associated with interictal burden. Previous studies have also shown a positive, albeit weaker, association between interictal burden and migraine/headache frequency [ 27 , 28 ]. This study showed a positive association between ictal disability (HIT-6) and interictal burden (MIBS-4) but did not explore specific biological or clinical drivers of interictal burden.…”

Section: Discussionmentioning

confidence: 99%

Measuring interictal burden among people affected by migraine: a descriptive survey study

et al. 2022

View full text Add to dashboard Cite

Background Previous research has extensively documented the impact of migraine episodes (‘ictal’) on patients’ health-related quality of life. Few studies have looked at the impact of migraine on migraine-free days (‘interictal’). This study was designed to describe interictal burden of migraine in a mixed group of people affected by migraine and to explore patient characteristics associated with interictal burden. Methods People with migraine in the United States (US) and Germany were recruited for a cross-sectional online survey, including a subgroup treated with calcitonin gene-related peptide (CGRP) monoclonal antibody (mAb). The survey included the Migraine Interictal Burden Scale (MIBS-4), Headache Impact Test (HIT-6), and items measuring patient demographics, clinical and treatment background. Data were analyzed using descriptive statistics and linear regression. Results Five hundred six people with migraine completed the survey (US: n = 257; Germany: n = 249), of whom 195 had taken a CGRP mAb for three or more months. Participants had a mean of 8.5 (SD = 6.4) Monthly Migraine Days (MMD) and 10.4 (SD = 7.1) Monthly Headache Days (MHD). The mean MIBS-4 score was 6.3 (SD = 3.4), with 67% reporting severe interictal burden (MIBS-4: ≥5). The mean HIT-6 score was 65.3 (SD = 6.0), with 86% reporting severe migraine impact (HIT-6: ≥60). MIBS-4 was correlated with the HIT-6 (r = 0.37), MMD and MHD (both r = 0.27). The HIT-6, MMD, MHD, CGRP mAb treatment, and depression all had an independent positive association with the MIBS-4. Conclusion Two-thirds of the study sample reported substantial interictal burden. Whilst interictal burden was associated with migraine frequency and impact of migraine attacks, study results also show it represented a distinct aspect of the overall disease burden. Study findings further indicate unique associations between interictal burden and depression. A unique positive association between interictal burden and CGRP mAb treatment suggests a remaining unmet need among people affected by migraine treated with CGRP mAb.

show abstract

Section: Discussionmentioning

confidence: 99%

Measuring interictal burden among people affected by migraine: a descriptive survey study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Migraine and tension-type headache (TTH) are included as primary headaches in the International Classification of Headache Disorders 3rd edition (ICHD-3) [ 3 ], and they are the main types of primary headaches. In Japan, the overall prevalence of migraine is 6.0–8.4%, and 74.2% of them complain that migraine headache impairs their daily activity significantly [ 4 – 7 ]. A previous study shows that Japanese migraine patients have an incremental burden compared to non-migraine patients in terms of decreased health-related quality of life, impaired productivities, more healthcare providers visits, and higher indirect costs [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Questionnaire-based survey on the prevalence of medication-overuse headache in Japanese one city—Itoigawa study

Katsuki¹,

Yamagishi²,

Matsumori³

et al. 2022

Neurol Sci

Self Cite

View full text Add to dashboard Cite

Objective The medication-overuse headache (MOH) prevalence has not been investigated in a general Japanese population. We performed questionnaire-based survey and revealed MOH prevalence and its characteristics. We also performed clustering to obtain insight for MOH subgrouping. Methods In this cross-sectional study, the 15–64-year-old population was investigated in Itoigawa during their COVID-19 vaccination under the national policy. MOH was defined as ≥ 15 days/month plus self-report of use of pain medications ≥ 10 or 15 days/month in the last 3 months. Ward method and k-means + + were used to perform clustering MOH patients. Results Among 5865 valid responses, MOH prevalence was 2.32%. MOH was common among females and the middle-aged. Combination-analgesic is the most overused as 50%. MOH had aggravation by routine physical activity, moderate or severe pain, and migraine-like, compared to non-MOH. The 136 MOH patients could be grouped into 3 clusters. Age and frequency of acute medication use were essential factors for clustering. Conclusions This is the first study of MOH prevalence in Japan. Most MOH characteristics were similar to previous reports worldwide. Public awareness of proper headache treatment knowledge is still needed. Clustering results may be important for subtype grouping from a social perspective apart from existing clinical subtypes.

show abstract

“…The 2 representative headaches are migraine and tension-type headache (TTH), and they are described in the International Classi cation of Headache Disorders 3rd edition (ICHD-3) [3]. Migraine impacts the quality of life, familial relationships, and work productivity [4]. In Japan, the total prevalence of migraine is 4.3-8.6% [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…Migraine impacts the quality of life, familial relationships, and work productivity [4]. In Japan, the total prevalence of migraine is 4.3-8.6% [4][5][6][7][8]. The economic and social impacts of migraine on productivity are starting to be recognized [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…The economic and social impacts of migraine on productivity are starting to be recognized [9,10]. Still, there was also a substantial unmet need for migraine care: 36.5% of respondents had hesitated to seek medical care for their headaches, and 89.8% had never used preventive medication [4]. Additionally, about 15-20% of Japanese individuals have TTH, and 22.4-29.2% complained that TTH disturbed their performances [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Headache Education for General Public by Leaflets Distribution During COVID-19 Vaccination and School-Based On-demand E-learning in Japanese One City -Itoigawa Geopark Headache Awareness Campaign-

Katsuki¹,

Matsumori²,

Kawahara³

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

Objective Headache is a common public health problem, but its burden could be avoided by raising headache awareness and the appropriate use of acute medication and prophylactic medication. Few reports on raising headache awareness in the general public have been reported, and there are no reports on headache awareness campaigns in Japan. We prospectively performed Itoigawa Headache Awareness Campaign from August 2021 to June 2022 and evaluated its effectiveness to the general public. Methods The main target group was the general public, especially those aged 15–64 y.o. We performed 2 projects; Project 1; Leaflet and paper-based headache awareness during COVID-19 vaccination, and Project 2; On-demand e-learning and online survey through schools. In these projects, we emphasize the 6 important topics for the general public, which were described in the Clinical Practice Guideline for Headache Disorders 2021. The awareness of the 6 topics among the 2 main projects’ cohorts before and after the campaign was evaluated. Results We obtained 4016 valid responses in project 1 and 2577 in project 2; thus, 32.23% of the working-age population of Itoigawa city experienced these projects. The ratios of individuals who know the 6 topics significantly increased after the 2 projects from 7–40% to 64–92% (p < 0.001, all). Conclusions We conducted this Itoigawa Headache Awareness Campaign through 2 main projects with improved ratios of individuals who know about the headache. The 2 methods of community-based awareness projects could raise headache awareness less costly and effectively.

show abstract

Burden of Migraine in Japan: Results of the ObserVational Survey of the Epidemiology, tReatment, and Care Of MigrainE (OVERCOME [Japan]) Study

Cited by 45 publications

References 33 publications

Measuring interictal burden among people affected by migraine: a descriptive survey study

Measuring interictal burden among people affected by migraine: a descriptive survey study

Questionnaire-based survey on the prevalence of medication-overuse headache in Japanese one city—Itoigawa study

Headache Education for General Public by Leaflets Distribution During COVID-19 Vaccination and School-Based On-demand E-learning in Japanese One City -Itoigawa Geopark Headache Awareness Campaign-

Contact Info

Product

Resources

About