Questionnaire-based survey on the prevalence of medication-overuse headache in Japanese one city—Itoigawa study

Abstract

Objective The medication-overuse headache (MOH) prevalence has not been investigated in a general Japanese population. We performed questionnaire-based survey and revealed MOH prevalence and its characteristics. We also performed clustering to obtain insight for MOH subgrouping. Methods In this cross-sectional study, the 15–64-year-old population was investigated in Itoigawa during their COVID-19 vaccination under the national policy. MOH was defined as ≥ 15 days/month plus self-report of use of pain medications ≥ 10 or 15 days/month in the last 3 months. Ward method and k-means + + were used to perform clustering MOH patients. Results Among 5865 valid responses, MOH prevalence was 2.32%. MOH was common among females and the middle-aged. Combination-analgesic is the most overused as 50%. MOH had aggravation by routine physical activity, moderate or severe pain, and migraine-like, compared to non-MOH. The 136 MOH patients could be grouped into 3 clusters. Age and frequency of acute medication use were essential factors for clustering. Conclusions This is the first study of MOH prevalence in Japan. Most MOH characteristics were similar to previous reports worldwide. Public awareness of proper headache treatment knowledge is still needed. Clustering results may be important for subtype grouping from a social perspective apart from existing clinical subtypes.

Transient Global Amnesia Related to the Third Coronavirus Disease-19 (COVID-19) Vaccination

“…The true mechanism is uncertain, but the vaccine’s coagulopathy seemed hypothesized. Apart from TGA, some population-based surveys at the COVID-19 vaccination venues have been also reported [ 10 , 11 ], so further research on the side effects of the COVID-19 vaccination like this and their follow-up should be reported.…”

Headache Education for General Public by Leaflets Distribution During COVID-19 Vaccination and School-Based On-demand E-learning in Japanese One City -Itoigawa Geopark Headache Awareness Campaign-

“…We performed the MOH prevalence survey at the rst-time COVID-19 vaccination from August to October 2021, called Itoigawa Study [5]. In the survey, we also handed out lea ets and survey sheets (Table 2) for this campaign in which the 6 topics were described.…”

“…This campaign was held by Itoigawa General Hospital in cooperation with Nou National Health Insurance Clinic, Itoigawa City, 3 high schools in Itoigawa City, SMS Corporation, and Regnition. The leading target group was the general public, especially those aged 15-64 y.o., for whom MOH prevalence is highest [5]. The time course is shown in Fig.…”

“…Migraine impacts the quality of life, familial relationships, and work productivity [4]. In Japan, the total prevalence of migraine is 4.3-8.6% [4][5][6][7][8]. The economic and social impacts of migraine on productivity are starting to be recognized [9,10].…”

The Efficacy of Japanese Herbal Kampo Medicine as an Acute and Prophylactic Medication to Treat Chronic Daily Headache and Medication Overuse Headache:-Single Arm Retrospective Study

“…About 5% of the normal population suffers from CDH [ 1 ]. The treatment for CDH is difficult because (1) acute medications are ineffective in 25% of patients, which can cause a transformation from episodic to chronic headache [ 2 ], medication-overuse headache (MOH) [ 3 , 4 ], and other side effects [ 5 ], and (2) prophylactic medications are ineffective in about 50% of patients and have side effects, leading to poor patient adherence, with more than half of the patients stopping treatment within two months [ 6 ]. In this context, alternative acute and prophylactic medications for CDH are needed.…”