Burden of invasive pneumococcal disease and serotype distribution among Streptococcus pneumoniae isolates in young children in Europe: impact of the 7-valent pneumococcal conjugate vaccine and considerations for future conjugate vaccines

Abstract

With routine effective use of PCV7, a general decline in IPD, antibiotic non-susceptibility, and vaccine serotypes has been observed. The most common IPD isolates since PCV7 introduction are serotypes 1, 19A, 3, 6A, and 7F, highlighting the need for inclusion of these serotypes in future vaccine formulations.

Potential serotype coverage of three pneumococcal conjugate vaccines against invasive pneumococcal infection in Italian children

“…At that time, the mean increases in potential coverage for PCV10 and PCV13 were 7% and 16%, respectively, for children <2 years of age [29]. Currently, data from countries constituting approximately 60% of the European population reveal that the most common IPD serotypes after the introduction of PCV7 are 1, 19A, 3, 6A, and 7F [29]. In particular in Portugal [30] and France [31] the 3 leading serotypes are 1, 19A and 7F, with similar percentages in the two countries (24-26%, 20-25% and 12-14% respectively).…”

“…The most common serotypes associated with IPD before the introduction of PCV7 were 14, 6B, 19F, and 23F, which are all covered by PCV7. At that time, the mean increases in potential coverage for PCV10 and PCV13 were 7% and 16%, respectively, for children <2 years of age [29]. Currently, data from countries constituting approximately 60% of the European population reveal that the most common IPD serotypes after the introduction of PCV7 are 1, 19A, 3, 6A, and 7F [29].…”

Prevalence of Heptavalent Vaccine- related Pneumococcal Serotypes in Nasopharyngeal carrier in children under five years old in Shahrekord, Iran by Multiplex-PCR during 2010- 2011

“…PCV7 has an efficacy of 94% against IPD due to serotypes included in the vaccine and 89% against any IPD, regardless of serotype, in a large pre-licensure clinical trial in California [20]. Since PCV7 introduction, the most common IPD isolates in Belgium, France, Germany, Greece, Norway, Portugal, Spain, and the UK were serotypes 1, 19A, 3, 6A, and 7F [21]. Infant PCV7 vaccination in Germany caused a decrease in pneumococcal meningitis similar to what happened in England and Wales [11].…”

Sensorineural hearing loss after bacterial meningitis in children

“…Литературные данные свидетельствуют о том, что на современном этапе БМ у детей представляют серьезную проблему в педиатрической практике, так как у одного из пяти пациентов с БМ формируются такие неврологические осложнения, как нейросенсорная тугоухость, судороги, нарушение движения, гидроцефалия, другие когнитивные и поведенческие нарушения [9,10,11,12,13]. Установлено, что менингит, вызванный S.pneumоniae, отличается неблагоприятным прогнозом, который приводит к наибольшей смертности, а у 30% выживших вызывает глубокую потерю слуха [12,13].…”