Burden of hepatitis C virus infection in India: A systematic review and meta‐analysis

Goel, Amit; Seguy, Nicole; Aggarwal, Rakesh

doi:10.1111/jgh.14466

Cited by 62 publications

(53 citation statements)

References 31 publications

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“…[6][7][8][9][10] One systemic review found prevalence of HCV (anti-HCV) to be 0.85% in community-based studies, 0.44% in blood donors and 0.88% among pregnant women in India. 3 In our study, the prevalence of HCV infection is 0.05% overall and 0.02% among pregnant women. It is less than other reports from different parts of India, West Bengal (0.87%.…”

Section: Discussionmentioning

confidence: 52%

“…2 One systemic review found prevalence of HCV (anti-HCV) to be 0.85% in community-based studies, 0.44% in blood donors and 0.88% among pregnant women in India. 3 HCV infection is associated with significant morbidity and mortality. The clinical spectrum of HCV infection spreads widely from asymptomatic infection to chronic liver disease, liver cirrhosis, liver failure and hepatocellular carcinoma.…”

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of hepatitis C virus among patients at a tertiary health care centre in Rajasthan, India

et al. 2020

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Background: To ascertain the prevalence of Hepatitis C infection among patients visiting a tertiary care center in Jaipur, Rajasthan.Methods: An observation analytic study was done at a tertiary care center affiliated to Medical College with retrospective analysis of the hospital data of two calendar years. During this period HCV infection screening (anti-HCV) was offered to every suspected patient admitted in hospital and every pregnant women visiting antenatal care clinic.Results: The study prevalence of HCV infection was 0.05% (13/25311). The prevalence was more in female (0.03%) than male (0.02%). The study prevalence of anti-HCV among pregnant female was 0.02% (3/16224). Maximum positive cases (4/13, 30.77% positive cases) were in the age group of 21-30 years (sexually active group) and >50 years age group while minimum positivity was found in children (00 case, 0-20 years age).Conclusions: In this study, prevalence of HCV infection was 0.05%. The study prevalence of HCV among pregnant females was 0.02%. Maximum positive cases (4/13, 30.77% positive cases) were in the age group of >50 years and 21-30 years. This study aids in view to strengthen proper screening for HCV infection to reduce HCV related morbidity and mortality

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Section: Discussionmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Seroprevalence of hepatitis C virus among patients at a tertiary health care centre in Rajasthan, India

et al. 2020

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“…HCV infection is not evenly distributed geographically [7]. Reasons for south Punjab's higher HCV prevalence are uncertain but could be due to poorer infection control practices, more syringe re-use or unreported IDU.…”

Section: Discussionmentioning

confidence: 99%

“…However, as India's population is 1.3 billion, the country contains approximately 10 million people living with HCV [6]. Despite a recent systematic review [7], the Indian HCV burden is poorly described because of a paucity of community-level data [7]. …”

Section: Introductionmentioning

confidence: 99%

Clustering of hepatitis C virus antibody positivity within households and communities in Punjab, India

et al. 2019

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To better understand hepatitis C virus (HCV) epidemiology in Punjab state, India, we estimated the distribution of HCV antibody positivity (anti-HCV+) using a 2013–2014 HCV household seroprevalence survey. Household anti-HCV+ clustering was investigated (a) by individual-level multivariable logistic regression, and (b) comparing the observed frequency of households with multiple anti-HCV+ persons against the expected, simulated frequency assuming anti-HCV+ persons are randomly distributed. Village/ward-level clustering was investigated similarly. We estimated household-level associations between exposures and the number of anti-HCV+ members in a household (N = 1593 households) using multivariable ordered logistic regression. Anti-HCV+ prevalence was 3.6% (95% confidence interval 3.0–4.2%). Individual-level regression (N = 5543 participants) found an odds ratio of 3.19 (2.25–4.50) for someone being anti-HCV+ if another household member was anti-HCV+. Thirty households surveyed had ⩾2 anti-HCV+ members, whereas 0/1000 (P < 0.001) simulations had ⩾30 such households. Excess village-level clustering was evident: 10 villages had ⩾6 anti-HCV+ members, occurring in 31/1000 simulations (P = 0.031). The household-level model indicated the number of household members, living in southern Punjab, lower socio-economic score, and a higher proportion having ever used opium/bhuki were associated with a household's number of anti-HCV+ members. Anti-HCV+ clusters within households and villages in Punjab, India. These data should be used to inform screening efforts.

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“…Globally an estimated 71 million individuals are infected with HCV out of which India is one of the six countries (others being China, Pakistan, Nigeria, Egypt & Russia) where more than 50% of the infected population resides [2] . A recent meta-analysis of HCV infection in Indian population predicted around 3 -9 million persons with active Hepatitis C infection [3].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Point of Care Molecular Diagnostic Genedrive HCV ID Kit for the detection of HCV RNA in clinical samples

Padhi¹,

Gupta²,

Singh³

et al. 2020

Epidemiol. Infect.

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Burden of hepatitis C virus infection in India: A systematic review and meta‐analysis

Cited by 62 publications

References 31 publications

Seroprevalence of hepatitis C virus among patients at a tertiary health care centre in Rajasthan, India

Seroprevalence of hepatitis C virus among patients at a tertiary health care centre in Rajasthan, India

Clustering of hepatitis C virus antibody positivity within households and communities in Punjab, India

Evaluation of the Point of Care Molecular Diagnostic Genedrive HCV ID Kit for the detection of HCV RNA in clinical samples

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