Burden of Fasciola hepatica Infection among Children from Paucartambo in Cusco, Peru

López, Martha; White, A. Clinton; Cabada, Miguel M.

doi:10.4269/ajtmh.2012.11-0448

Cited by 40 publications

(43 citation statements)

References 19 publications

(18 reference statements)

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“…For example, the frequency of Fasciola eggs in stool in Ohuay was 0%, whereas eosinophilia was present in onehalf of children. Stool studies 2 years before this study documented Fasciola ova in 6% of children in Ohuay, 9 and the current absence of ova may reflect the poor sensitivity of a single microscopic examination, especially in early phases of infection. In acute infection before invasion of the biliary tract, fascioliasis cannot be detected by stool examination.…”

Section: Discussionmentioning

confidence: 99%

“…2 However, it has been noted that the epidemiology of Fasciola infection is highly variable, even within small geographic regions. 9,26 Thus, studies evaluating local patterns of transmission are important to tailor interventions based on regional data.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have suggested an association of fascioliasis with anemia and nutritional deficiencies, which could cause irreversible developmental deficits. [7][8][9][10] Hyperendemic areas (prevalence 10%) for fascioliasis have been described throughout the Peruvian highlands. 11,12 A risk factor for Fasciola transmission recognized in a casecontrol study in children from the Peruvian Altiplano is the consumption of raw vegetables (alfalfa juice).…”

Section: Introductionmentioning

confidence: 99%

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Fascioliasis and Eosinophilia in the Highlands of Cuzco, Peru and Their Association with Water and Socioeconomic Factors

Cabada¹,

Goodrich²,

Graham³

et al. 2014

The American Journal of Tropical Medicine and Hygiene

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Abstract. There are limited data about the epidemiology of fascioliasis in Cuzco, Peru. We studied children 3-12 years old from six communities in the highlands of Cuzco to evaluate the epidemiology of fascioliasis; 227 children were included, one-half were female, the mean age was 7.5 (±2.6) years, and 46.2±% had one or more parasites, including Fasciola (9.7%), Ascaris (12.8%), Hymenolepis (9.3%), Trichuris (1.3%), hookworm (1.8%), Strongyloides (0.9%), and Giardia (27.8%). Fasciola was associated with the number of siblings in the household, drinking untreated water, and giardiasis. Eosinophilia was encountered in 21% of children and more common in those drinking untreated water at home and those infected with a parasite, but the differences were not significant. Eating water plants was not associated with Fasciola or eosinophilia. Fascioliasis and eosinophilia were common in the highlands of Cuzco. Fascioliasis was associated with socioeconomic factors and drinking water. BACKGROUND

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fascioliasis and Eosinophilia in the Highlands of Cuzco, Peru and Their Association with Water and Socioeconomic Factors

Cabada¹,

Goodrich²,

Graham³

et al. 2014

The American Journal of Tropical Medicine and Hygiene

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“…8,9 Lopez et al investigated the prevalence of Fasciolosis in school age children in Peru and they reported that 10.3% had positive stool microscopy. 10 There have been several epidemiologic studies on Fasciolosis in Turkey. In the Bagtepe village of Kozan/Adana, IHA was used and performed with a 1/320 dilution; seropositivity was seen in 3.78% of the population, whereas seropositivity was 3.01% in ten villages in Antalya and the Lakes region.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Fasciola hepatica Seropositivity in Forensic Autopsies in the Çukurova Region

Zeren¹,

Eren²,

Çelikel³

et al. 2013

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T OOb bj je ec ct ti iv ve e: : Fasciola hepatica is a parasite that affects ruminant animals and is rarely seen in humans. The agent may cause significant health problems and economic loss as a zoonotic disease. Freshwater plants play an important role for infecting humans with this parasite. Eating watercress, drinking water that contains metacercaria, using contaminated kitchen tools, or consuming green vegetables may cause infestation. Green vegetables and fruits, especially watercress, are grown specifically in the Cukurova region and this puts the population living in this region at risk of developing fasciolosis. For the reason of absence of the seroprevalence studies in autopsies and to determine the prevalence of this region, the aim of this study, is to investigate F. hepatica antibody by the method of IHA blood samples which were taken from autopsy cases in the Çukurova Region. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : This study was conducted in Adana Forensic Medicine Department, a center where all forensic autopsies from the cities of Adana, Mersin, Kahramanmaras, Hatay and Osmaniye were performed. There were 94 subjects between the ages of 2-87 years (mean:42.55±SD22.09) and their serum samples were collected for assessment of F. hepatica antibodies via the IHA method. Moreover, we examined the hepatobiliary system for adult parasites. R Re es su ul lt ts s: : IHA results demonstrated that 13 (13.8%) of the subjects were seropositivite for F. hepatica. During the autopsy, however, mature F. hepatica was not observed in hepatobiliary systems of the subjects. Seropositivity rates in Adana, Mersin, Hatay and Osmaniye were 19.4%, 7.1%, 12.5% and 22.2%, respectively. C Co on nc cl lu us si io on n: : To our knowledge, this is the first study evaluating F. hepatica seropositivity in forensic autopsies. Seeing the results, we suggest that more comprehensive epidemiologic research is needed to study this infestation, especially in endemic areas. K Ke ey y W Wo or rd ds s: : Fasciola hepatica; autopsy; forensic medicine Ö ÖZ ZE ET T A Am ma aç ç: : Geviş getiren hayvanların paraziti olan Fasciola hepatica insanlarda nadir görülen, önemli sağlık sorunlarına ve ekonomik kayıplara neden olabilen zoonotik bir hastalıktır. Parazitin insanlara bulaşmasında tatlı su bitkileri önemli rol oynamaktadır. Hastalık metaserkarya'nın bulunduğu su teresinin yenilmesi, suların içilmesi veya bunlarla kontamine olmuş mutfak aletlerin kullanılması ve yeşil sebzelerin tüketilmesiyle bulaşabilmektedir. Çukurova Bölgesinde özellikle su teresi gibi yeşil sebze ve meyveler bol miktarda tüketilmektedir, bu nedenle birçok insan fasciolosis bakımından büyük bir risk altındadır. Otopsilerde seroprevalans çalışmamaların olmaması ve bu bölgedeki yaygınlığın belirlenmesi amacıyla bu çalışmada, Çukurova Bölgesinde adli otopsi vakalarından alınan kan örneklerinde, IHA yöntemi ile anti-F. hepatica antikorlarının araştırılması amaçlanmıştır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Araştı...

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“…Asimismo, es la zoonosis helmíntica más importante en varias regiones del mundo, afectando principalmente a humanos, bovinos, ovinos y caprinos (Robinson y Dalton, 2009). La enfermedad humana y animal está distribuida en el 71% del territorio peruano y es endémi-ca de la sierra (Claxton et al, 1997;Marcos et al, 2004;Valencia et al, 2005;Lopez et al, 2012). En la provincia de Cajamarca, donde la industria lechera es una actividad económica importante, la prevalencia en el ganado bovino es superior al 75% (SENASA, 2007).…”

Section: Introductionunclassified

Inmunidad Celular en Ganado Vacuno Lechero Naturalmente Infectado con Fasciola hepatica en Cajamarca, Perú

Silva-Díaz

Hobán

Cerna

et al. 2015

Rev. investig. vet. Perú

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RESUMENLa fasciolosis producida por Fasciola hepatica es una importante enfermedad parasitaria de la ganadería en muchos países. En Cajamarca, Perú, se reportan prevalencias superiores al 80% en el ganado lechero. El objetivo del estudio fue evaluar la capacidad de proliferación y la expresión de citoquinas (IFN-γ e IL-4) en células mononucleares de sangre periférica de terneras y vacas naturalmente infectadas, contra el antígeno no específico fitohemaglutinina y los antígenos específicos de excreción-secreción del estadio inmaduro y maduro de F. hepatica. La capacidad proliferativa fue determinada por linfoproliferación in vitro y la expresión de citoquinas se evaluó en sobrenadantes de cultivo celular por la técnica de ELISA. Las vacas infectadas con F. hepatica mostraron una disminución de la capacidad de respuesta frente a estímulos proliferativos inespecíficos y específicos. En el perfil de citoquinas contra el estímulo específico se encontró una baja expresión de IFN-γ, mientras que la respuesta de IL-4 fue alta, lo que indica que la respuesta permanece polarizada hacia una respuesta de tipo Th2. En el análisis comparativo, las terneras expresaron niveles de IFN-γ más altos que los valores obtenidos en las vacas, pero con una expresión similar de IL-4. No se observaron diferencias en la respuesta inmune a los antígenos del estadio inmaduro y maduro del parásito. Los resultados demuestran que a medida que la enfermedad progresa se expresa una respuesta inmunomoduladora en los animales adultos naturalmente infectados con F. hepatica.

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Burden of Fasciola hepatica Infection among Children from Paucartambo in Cusco, Peru

Cited by 40 publications

References 19 publications

Fascioliasis and Eosinophilia in the Highlands of Cuzco, Peru and Their Association with Water and Socioeconomic Factors

Fascioliasis and Eosinophilia in the Highlands of Cuzco, Peru and Their Association with Water and Socioeconomic Factors

Investigation of Fasciola hepatica Seropositivity in Forensic Autopsies in the Çukurova Region

Inmunidad Celular en Ganado Vacuno Lechero Naturalmente Infectado con Fasciola hepatica en Cajamarca, Perú

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