Bupropion for Attention Deficit Hyperactivity Disorder (ADHD) in adults

Verbeeck, W.; Bekkering, Geertruida; Noortgate, Wim Van den

doi:10.1002/14651858.cd009504

Cited by 12 publications

(10 citation statements)

References 56 publications

(82 reference statements)

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“…In addition, prescribers and athletes should be aware that it takes much longer to see full benefit from atomoxetine than from stimulants,309 and gastrointestinal discomfort and sedation are possible side effects 327. Bupropion, an antidepressant with some stimulant properties, is sometimes used off label for ADHD,306 322 335 especially for individuals with comorbid depression. Clonidine and guanfacine in extended release formulations are approved in some countries for use in children under the age of 18 years with ADHD (which could include elite athletes) 325 336.…”

Section: Specific Mental Health Symptoms and Disorders In Elite Athletesmentioning

confidence: 99%

Mental health in elite athletes: International Olympic Committee consensus statement (2019)

et al. 2019

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Mental health symptoms and disorders are common among elite athletes, may have sport related manifestations within this population and impair performance. Mental health cannot be separated from physical health, as evidenced by mental health symptoms and disorders increasing the risk of physical injury and delaying subsequent recovery. There are no evidence or consensus based guidelines for diagnosis and management of mental health symptoms and disorders in elite athletes. Diagnosis must differentiate character traits particular to elite athletes from psychosocial maladaptations.Management strategies should address all contributors to mental health symptoms and consider biopsychosocial factors relevant to athletes to maximise benefit and minimise harm. Management must involve both treatment of affected individual athletes and optimising environments in which all elite athletes train and compete. To advance a more standardised, evidence based approach to mental health symptoms and disorders in elite athletes, an International Olympic Committee Consensus Work Group critically evaluated the current state of science and provided recommendations.

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Section: Specific Mental Health Symptoms and Disorders In Elite Athletesmentioning

confidence: 99%

Mental health in elite athletes: International Olympic Committee consensus statement (2019)

et al. 2019

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“…Bupropion is also used for seasonal affective disorder, smoking cessation, 2 obesity, 3 and attention deficit hyperactivity disorder in adults and children. 4 Bupropion undergoes extensive metabolism, with less than 1% recovered intact in urine, to the three primary metabolites hydroxybupropion (via t-butylhydroxylation), and the isomers threohydrobupropion and erythrohydrobupropion (via keto reduction). Hydroxybupropion exposure is approximately an order of magnitude greater than that of parent drug.…”

Section: What Question Did This Study Address?mentioning

confidence: 99%

Common Polymorphisms of CYP2B6 Influence Stereoselective Bupropion Disposition

Kharasch

Crafford

2018

Clin Pharma and Therapeutics

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Bupropion hydroxylation is a bioactivation and metabolic pathway, and the standard clinical CYP2B6 probe. This investigation determined the influence of CYP2B6 allelic variants on clinical concentrations and metabolism of bupropion enantiomers. Secondary objectives evaluated the influence of CYP2C19 and P450 oxidoreductase variants. Healthy volunteers in specific cohorts (CYP2B6*1/*1, CYP2B6*1/*6, CYP2B6*6/*6, and also CYP2B6*4 carriers) received single-dose oral bupropion. Plasma and urine bupropion and hydroxybupropion was quantified. Subjects were also genotyped for CYP2C19 and P450 oxidoreductase variants. Hydroxylation of both bupropion enantiomers, assessed by plasma hydroxybupropion/bupropion AUC ratios and urine hydroxybupropion formation clearances, was lower in CYP2B6*6/*6 but not CYP2B6*1/*6 compared with CYP2B6*1/*1 genotypes, and numerically greater in CYP2B6*4 carriers. CYP2C19 and P450 oxidoreductase variants did not influence bupropion enantiomers hydroxylation or plasma concentrations. The results show that clinical hydroxylation of both bupropion enantiomers was equivalently influenced by CYP2B6 allelic variation. CYP2B6 polymorphisms affect S-bupropion bioactivation, which may affect therapeutic outcomes.

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“…Bupropion, an antidepressant with some stimulant properties via dopamine and norepinephrine reuptake inhibition, is sometimes used off-label for ADHD,9 77 especially for individuals with comorbid depression. In addition, the alpha-2 agonists clonidine and guanfacine in extended-release formulations are approved in some countries for use in children under the age of 18 with ADHD 78.…”

Section: Introductionmentioning

confidence: 99%

Attention-deficit/hyperactivity disorder in elite athletes: a narrative review

et al. 2019

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Attention-deficit/hyperactivity disorder (ADHD) is a common brain developmental disorder in the general population that may be even more prevalent in elite athletes in certain sports. General population studies of ADHD are extensive and have reported on prevalence, symptoms, therapeutic and adverse effects of treatment and new clinical and research findings. However, few studies have reported on prevalence, symptoms and treatments of ADHD in elite athletes. This narrative review summarises the literature on symptoms, comorbidities, effects of ADHD on performance and management options for elite athletes with ADHD. The prevalence of ADHD in student athletes and elite athletes may be 7%–8%. The symptoms and characteristics of ADHD play a role in athletes’ choice of a sport career and further achieving elite status. Proper management of ADHD in elite athletes is important for safety and performance, and options include pharmacologic and psychosocial treatments.

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Bupropion for Attention Deficit Hyperactivity Disorder (ADHD) in adults

Abstract: Analysis 2.3. Comparison 2 Bupropion versus placebo (sensitivity analyses), Outcome 3 Achievement of significant clinical improvement (% participants

Cited by 12 publications

References 56 publications

Mental health in elite athletes: International Olympic Committee consensus statement (2019)

Mental health in elite athletes: International Olympic Committee consensus statement (2019)

Common Polymorphisms of CYP2B6 Influence Stereoselective Bupropion Disposition

Attention-deficit/hyperactivity disorder in elite athletes: a narrative review

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