Buprenorphine-induced Symptomatic Hypogonadism in Men: Case Reports and Discussion

Colameco, Stephen; Coren, Joshua S.; Zimmerman, Daniel J.

doi:10.1097/adm.0b013e318172d612

Cited by 9 publications

(3 citation statements)

References 18 publications

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“…Evidence of the direct effects of opioids on testicular function has also been reported in animal studies (13). Another study suggests that buprenorphine, like other opiates, may cause the serum levels of testosterone to reduce below the normal range (14). This finding is supported by another cross-sectional study that showed that 28% of buprenorphine-and 65% of methadone-receiving patients had lower serum testosterone levels than those in age-matched patients in control group.…”

Section: Discussionmentioning

confidence: 88%

A Quantitative and Qualitative Study of Rat Testis Following Administration of Methadone and Buprenorphine

Heidari

Mahmoudzadeh‐Sagheb

Kohan

2012

Int J High Risk Behav Addict

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This article focuses on quantitative and qualitative changes in rat testes after methadone and buprenorphine administration. Considering high prevalence of Opiate abuse and treatment of Opiate addiction among adolescent men, it is necessary to find out the effects of these drugs on testes. This study is recommended to Basic medical sciences researchers, Urologists, Psychologists, and also for informing the general population, particularly the youth, of the probable consequences of opioids drugs.

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Section: Discussionmentioning

confidence: 88%

A Quantitative and Qualitative Study of Rat Testis Following Administration of Methadone and Buprenorphine

Heidari

Mahmoudzadeh‐Sagheb

Kohan

2012

Int J High Risk Behav Addict

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“…Opioid-induced endocrinopathy appears to be a class phenomenon. The partial opioid agonist buprenorphine is also associated with hypogonadism, but to a lesser extent than the full opioid agonist methadone (8,9).…”

mentioning

confidence: 98%

Opioid-Induced Endocrinopathy: Diagnosis and Screening

Colameco

2012

Journal of Pain & Palliative Care Pharmacotherapy

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Opioid prescribing in Europe has continued to increase since the 2005 Pain in Europe report, which highlighted that a significant number of patients were treated with opioid analgesics. Chronic opioid use can cause secondary hypogonadism, affecting up to 5 million men in the USA and Canada treated for chronic noncancer pain. Studies have raised concerns regarding an increased risk of osteopenia associated with daily opioid use patients for opioid-induced hypogonadism, but more subtle signs and symptoms make screening more challenging in women than in men. Monitoring total testosterone blood level does not reliably determine the risk of developing opioid-associated osteoporosis. There is no consensus on when to screen.

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“…Again this study was limited by the small sample size. A case series (4) reported hypogonadism in 10 patients receiving BMT without comparing it to methadone. The pharmacological profile of buprenorphine is different than methadone.…”

mentioning

confidence: 99%

Hypogonadism and Low Testosterone Levels as a Side Effect of Methadone and Buprenorphine

Fareed

2012

Int J High Risk Behav Addict

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Buprenorphine-induced Symptomatic Hypogonadism in Men: Case Reports and Discussion

Cited by 9 publications

References 18 publications

A Quantitative and Qualitative Study of Rat Testis Following Administration of Methadone and Buprenorphine

A Quantitative and Qualitative Study of Rat Testis Following Administration of Methadone and Buprenorphine

Opioid-Induced Endocrinopathy: Diagnosis and Screening

Hypogonadism and Low Testosterone Levels as a Side Effect of Methadone and Buprenorphine

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