Buparvaquone mucoadhesive nanosuspension: preparation, optimisation and long-term stability

Müller, Rainer H.; Jacobs, Claudia

doi:10.1016/s0378-5173(02)00040-6

Cited by 231 publications

(103 citation statements)

References 13 publications

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“…In our study, the zeta potential was about À20 mV. Although it was below the critical value, we also could say the formulation has the long-term stability as a result of the use of nonionic surfactants which offered strong steritical hindrance (Müller & Jacobs, 2002;Jia et al, 2010b). The non-ionic surfactant used in this work was F68 and aggregation of nanoparticle was avoided due to sufficient steritical hindrance.…”

Section: Particle Size and Zeta Potential Analysismentioning

confidence: 54%

Design and characterization of Amoitone B-loaded nanostructured lipid carriers for controlled drug release

et al. 2013

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Amoitone B, a novel compound chemically synthesized as the analogue of cytosporone B, has been proved to own superior affinity with Nur77 than its parent compound and exhibit notable anticancer activity. However, its application is seriously restricted due to the water-insolubility and short biological half-time. The aim of this study was to construct an effective delivery system for Amoitone B to realize sustained release, thus prolong drug circulation time in body and improve the bioavailability. Nanostructured lipid carriers (NLC) act as a new type of colloidal drug delivery system, which offer the advantages of improved drug loading and sustained release. Amoitone B-loaded NLC (AmB-NLC) containing glyceryl monostearate (GMS) and various amounts of medium chain triglycerides (MCT) were successfully prepared by emulsion-evaporation and low temperature-solidification technology with a particle size of about 200 nm and a zeta potential value of about À20 mV. The results of X-ray diffraction and DSC analysis showed amorphous crystalline state of Amoitone B in NLC. Furthermore, the drug entrapment efficacy (EE) was improved compared with solid lipid nanoparticles (SLN). The EE range was from 71.1% to 84.7%, enhanced with the increase of liquid lipid. In vitro drug release studies revealed biphasic drug release patterns with burst release initially and prolonged release afterwards and the release was accelerated with augment of liquid lipid. These results demonstrated that AmB-NLC could be a promising delivery system to control drug release and improve loading capacity, thus prolong drug action time in body and enhance the bioavailability.

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Section: Particle Size and Zeta Potential Analysismentioning

confidence: 54%

Design and characterization of Amoitone B-loaded nanostructured lipid carriers for controlled drug release

et al. 2013

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“…However, despite a zeta potential above the critical value of −30 mV, micelles can have the same long-term stability, in case the sterical hindrance layer is sufficiently thick. 24 In our study, the drug-load micelles were stable with good fluidity when sealed and stored under conditions such as refrigeration or at room temperature for three months. The appearance and drug-loading efficiencies hardly changed.…”

Section: Characterization Of Drug-loaded Micellesmentioning

confidence: 61%

Folate-mediated targeted and intracellular delivery of paclitaxel using a novel deoxycholic acid-O-carboxymethylated chitosan–folic acid micelles

Zhang¹,

Wang²

2012

IJN

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Background: A critical disadvantage for successful chemotherapy with paclitaxel (PTX) is its nontargeting nature to cancer cells. Folic acid has been employed as a targeting ligand of various anticancer agents to increase their cellular uptake within target cells since the folate receptor is overexpressed on the surface of such tumor cells. In this study, a novel biodegradable deoxycholic acid-O-carboxymethylated chitosan-folic acid conjugate (DOMC-FA) was used to form micelles for encapsulating the anticancer drug PTX. Methods and results:The drug-loading efficiency, encapsulation efficiency, in vitro drug release and physicochemical properties of PTX-loaded micelles were investigated in detail. In vitro cell culture studies were carried out in MCF-7 cells, a human breast carcinoma cell line, with folate receptor overexpressed on its surface. An increased level of uptake of folateconjugated micelles compared to plain micelles in MCF-7 cells was observed, and the enhanced uptake of folate-micelles mainly on account of the effective process of folate receptor-mediated endocytosis. The MTT assay, morphological changes, and apoptosis test implied that the folateconjugated micelles enhanced the cell death by folate-mediated active internalization, and the cytotoxicity of the FA-micellar PTX (DOMC-FA/PTX) to cancer cells was much higher than micelles without folate (DOMC/PTX) or the commercially available injectable preparation of PTX (Taxol). Conclusion: Results indicate that the PTX-loaded DOMC-FA micelle is a successful anticancertargeted drug-delivery system for effective cancer chemotherapy.

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“…In general, the zeta potential values higher than −30 mV signify long-term stability of aqueous dispersion. However, despite a zeta potential below the critical value of −30 mV, nanoparticles can have the same long-term stability, in case the sterically stabilizing layer is sufficiently thick (Müller et al, 2001;Müller & Jacobs, 2002).…”

Section: Resultsmentioning

confidence: 99%

Preparation and characterization of silybin-loaded nanostructured lipid carriers

Jia¹,

Zhang²,

Li³

et al. 2009

Drug Delivery

100

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Buparvaquone mucoadhesive nanosuspension: preparation, optimisation and long-term stability

Cited by 231 publications

References 13 publications

Design and characterization of Amoitone B-loaded nanostructured lipid carriers for controlled drug release

Design and characterization of Amoitone B-loaded nanostructured lipid carriers for controlled drug release

Folate-mediated targeted and intracellular delivery of paclitaxel using a novel deoxycholic acid-O-carboxymethylated chitosan–folic acid micelles

Preparation and characterization of silybin-loaded nanostructured lipid carriers

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Buparvaquone mucoadhesive nanosuspension: preparation, optimisation and long-term stability

Cited by 231 publications

References 13 publications

Design and characterization of Amoitone B-loaded nanostructured lipid carriers for controlled drug release

Design and characterization of Amoitone B-loaded nanostructured lipid carriers for controlled drug release

Folate-mediated targeted and intracellular delivery of paclitaxel using a novel deoxycholic acid-O-carboxymethylated chitosan&ndash;folic acid micelles

Preparation and characterization of silybin-loaded nanostructured lipid carriers

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Folate-mediated targeted and intracellular delivery of paclitaxel using a novel deoxycholic acid-O-carboxymethylated chitosan–folic acid micelles