Preparation and characterization of silybin-loaded nanostructured lipid carriers

Jia, Lejiao; Zhang, Dianrui; Li, Zhenyu; Feng, Feifei; Wang, Yan-cai; Dai, Wenting; Duan, Cunxian; Zhang, Qiang

doi:10.3109/10717540903431586

Cited by 100 publications

(48 citation statements)

References 24 publications

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“…In the previous research, a second reason was given to describe the size enlargement of nanoparticles by adding oil up to 20 wt%. 65 The effects of variables on the size of SLN and NLC particles are summarized in Table 1.…”

Section: Impact Of Variables On Size Of Slns and Nlcsmentioning

confidence: 99%

The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review

Bahari¹,

Hamishehkar²

2016

Adv Pharm Bull

172

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Section: Impact Of Variables On Size Of Slns and Nlcsmentioning

confidence: 99%

The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review

Bahari¹,

Hamishehkar²

2016

Adv Pharm Bull

172

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“…Derivatives of silybin with improved solubility may surmount these pharmacologic limitations [15,16]. The silybin phytosome complex (silybin plus phosphatidylcholine) has been coformulated with vitamin E (Realsil (RA); Istituto Biochimico Italiano, Lorenzini S.p.a., Italy).…”

mentioning

confidence: 99%

Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: A randomized controlled trial

Loguercio

Andreone

Brisc

et al. 2012

Free Radical Biology and Medicine

214

147

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The only currently recommended treatment for nonalcoholic fatty liver disease (NAFLD) is lifestyle modification. Preliminary studies of silybin showed beneficial effects on liver function. Realsil (RA) comprises the silybin phytosome complex (silybin plus phosphatidylcholine) coformulated with vitamin E. We report on a multicenter, phase III, double-blind clinical trial to assess RA in patients with histologically documented NAFLD. Patients were randomized 1:1 to RA or placebo (P) orally twice daily for 12 months. Prespecified primary outcomes were improvement over time in clinical condition, normalization of liver enzyme plasma levels, and improvement of ultrasonographic liver steatosis, homeostatic model assessment (HOMA), and quality of life. Secondary outcomes were improvement in liver histologic score and/or decrease in NAFLD score without worsening of fibrosis and plasma changes in cytokines, ferritin, and liver fibrosis markers. We treated 179 patients with NAFLD; 36 were also HCV positive. Forty-one patients were prematurely withdrawn and 138 patients analyzed per protocol (69 per group). Baseline patient characteristics were generally well balanced between groups, except for steatosis, portal infiltration, and fibrosis. Adverse events (AEs) were generally transient and included diarrhea, dysgeusia, and pruritus; no serious AEs were recorded. Patients receiving RA but not P showed significant improvements in liver enzyme plasma levels, HOMA, and liver histology. Body mass index normalized in 15% of RA patients (2.1% with P). HCV-positive patients in the RA but not the P group showed improvements in fibrogenesis markers. This is the first study to systematically assess silybin in NAFLD patients. Treatment with RA but not P for 12 months was associated with Free

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“…The nearer the value of polydispersity to zero, the higher is the homology between the particles. The polydispersity index of microemulsion was 0.429 ± 0.09 (Table 4), indicating wide particle size distributions (Jia et al, 2010). These results suggest that the mixture favoured to form nanoparticles with more homogenous size distributions due to size reduction.…”

Section: Measurement Of Particle Size and Zeta Potentialmentioning

confidence: 57%

Anti-HSV type-1 activity of olive leaves extract crude form acting as a microemulsion dosage form

Khattab¹,

Hosny²,

Abdelkawy³

et al. 2016

Afr. J. Microbiol. Res.

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Olea europeae (L.) has been reported to have antibacterial, antifungal and antiviral activities. The aim of the present study is to evaluate antiviral activity of olive leaves extract (OLE) against herpes simplex viruses (HSV) type-1 virus. Screening of antiviral activity was assessed by measuring inhibition of viralinduced cytopathic effect of in vero cells of different OLE fractions that have been successively extracted using solvents of increasing polarities, against HSV type-1 virus. Negligible antiviral activity has been shown of different fractions, except for ethyl acetate and n-butanol fractions, showing strong and moderate anti-HSV type -1 activity, respectively. High performance liquid chromatography (HPLC) chromatographic analysis of both fractions revealed high oleuropein content in ethyl acetate fraction in addition to other phenolic and flavonoid contents, whereas n-butanol fraction showed only high content of other phenolic and flavonoid compounds. Cytotoxicity of ethyl acetate fraction was assessed in vero cell line, the mean cytotoxic concentration CC50, was reported to be 610 µg/ml. On the other hand, the 50% inhibitory concentration (IC50), against HSV-1, was of value as low as 40 µg/ml (SI = 15.2). This concentration could be more reduced to 33 µg/ml (SI = 16.9); that is, 17% reduction in dose, by formulating a microemulsion dosage form, with particle size of 13 to 19 nm, being assessed by Malvern Zetasizer Ver. 6.2 and electron microscopy. Acyclovir, a recommended anti-HSV agent, was used as a positive control. Oleuropein pure standard and the main phenolic component of OLE, was also assessed for its anti-HSV type-1 virus. As conclusion, microemulsion formulation enhanced antiviral activity of crude OLE.

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Preparation and characterization of silybin-loaded nanostructured lipid carriers

Cited by 100 publications

References 24 publications

The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review

The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review

Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: A randomized controlled trial

Anti-HSV type-1 activity of olive leaves extract crude form acting as a microemulsion dosage form

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