Bunium persicum: A Review of Ethnopharmacology, Phytochemistry, and Biological Activities

Abstract

Bunium persicum (Boiss) B. Fedtsh (Apiaceae, Persian name: Zireh Kermani) has been used to treat various diseases in traditional and folkloric medicine including gastrointestinal, respiratory, nasopharyngeal, cardiac, ocular, neurological, rheumatological and urinary tract diseases. Its essential oil contains different monoterpenes, sesquiterpenes and phenyl propenes. Other chemical constituents identified in B. persicum are phenolic compounds, fatty acids, carboxylic acids, and carbohydrates. Wide range of biological and pharmacological activities including antioxidant, analgesic, anti-inflammatory, acetylcholinesterase inhibitory, anticonvulsant, HMG-CoA reductase inhibitory, anti-pancreatic lipase, anticancer, antidiabetic, antihistamine, antidiarrheal, antispasmodic, antihematoxic, antityrosinase and antimicrobial activities have been reported from this plant in modern medicine. This article summarizes comprehensive information attributing traditional uses, phytochemistry, and pharmacological activities of Zireh Kermani.

Phytochemical and biological activities of some Iranian medicinal plants

“…2012 ; Majidi et al. 2020 ). The DPPH and ABTS radical scavenging assays results indicated that the antioxidant activity of Zataria multiflora Boiss.…”

The Efficacy of The Herbal Formula of Bunium Persicum and Coriandrum Sativum on Clinical Symptoms of Patients with Functional Dyspepsia: A Double-Blind Randomized Controlled Trial

“…The multi-component formula of herbal medicine, as the most frequently used modality of CAM in FGID, can modify GI function with a wide variety of mechanisms that have not been fully clari ed (8,9) in Asian countries for various medicinal purposes including gastrointestinal (diarrhea, atulence) (10).…”

“…persicum is an important aromatic medical plant that belongs to the Apiaceae family with many bioactive components in its seeds including cuminaldehyde, α-terpinene-7-al, γ-terpinene-7-al, γ-terpinene, ρ-cymene, β-Pinene, etc. Several pharmacological activities like antioxidant, anti-in ammatory, analgesic, acetylcholinesterase inhibitory, anticonvulsant, HMG-CoA reductase inhibitory, anticancer, anti-pancreatic lipase, antihistamine, antidiabetic, antispasmodic, antidiarrheal, antihepatotoxic, antityrosinase, and antimicrobial activities have been reported for this plant (10,11). B. persicum can stimulate the intestinal motility and reduce signi cantly the time intervals to the passage of atus, rst bowel movement, and hospital discharge after a cesarean section (12,13).…”

The Effect of a Persian Herbal Medicine Compound on the Lipid Profiles of Patients with Dyslipidemia: A Randomized Double-Blind Placebo-Controlled Clinical Trial

“…Combination therapy is more effective in many cases of dyslipidemia [16,17]. Various studies in herbal and complementary medicine have proven medicinal plants to be effective in treating dyslipidemia [18][19][20][21][22]. Cooperative use of certain foods or herbal medications may increase or decrease the therapeutic effects of statins.…”