Bullous Systemic Lupus Erythematosus in a Child Responding to Dapsone

Liu, Kwei-Lan; Shen, Jui-Lung; Yang, Chii-Shuenn; Chen, Yi–Ju

doi:10.1111/pde.12340

Cited by 17 publications

(15 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Its efficacy in SLE, especially in the bullous forms of the disease, has been described in some case reports [8,20,21,22,23,24,25,26]. One case of bullous SLE with signs of SLE was reported in 2013 by Grover et al [24].…”

Section: Discussionmentioning

confidence: 96%

Dapsone as Second-Line Treatment for Cutaneous Lupus Erythematosus? A Retrospective Analysis of 34 Patients and a Review of the Literature

2015

View full text Add to dashboard Cite

Background: A variety of therapeutic options have been reported for cutaneous lupus erythematosus (CLE); one of these is dapsone. However, no high priority has been given to this drug. Objective: To determine whether dapsone is an effective and safe treatment alternative in patients with LE. Methods: We reviewed the literature and analyzed retrospectively 34 CLE patients who were treated with dapsone as monotherapy or combined with antimalarials. We assessed the course of the disease under treatment, response, concomitant treatment and side effects. Results: Six patients went into remission, 14 patients improved, and in 6 patients disease remained constant during the observation period. Dapsone was discontinued in 9 patients: in 4 due to reversible side effects and in 5 patients due to poor efficacy. Conclusion: Our data confirm that dapsone with/without antimalarials is effective in more than 50% of patients with CLE and could be used as second-line therapy for CLE.

show abstract

Section: Discussionmentioning

confidence: 96%

Dapsone as Second-Line Treatment for Cutaneous Lupus Erythematosus? A Retrospective Analysis of 34 Patients and a Review of the Literature

2015

View full text Add to dashboard Cite

show abstract

“…More than 70% of children with SLE have skin lesions, and in one-third they may be the presenting feature (2,3,5). The spectrum of CLE and its relationship to SLE has been well characterized in adults, but the data in children are limited to isolated case reports or small series focusing on one subset of CLE (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). A few reports have included the whole spectrum of CLE in children (3)(4)(5).…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Lupus Erythematosus in Children: Experience from a Tertiary Care Pediatric Dermatology Clinic

AlKharafi

Alsaeid

AlSumait

et al. 2016

Pediatric Dermatology

View full text Add to dashboard Cite

show abstract

“…In individuals without systemic complications, dapsone can be tried first. A number of individuals have responded dramatically to dapsone within 1–2 days …”

Section: Discussionmentioning

confidence: 99%