Cutaneous Lupus Erythematosus in Children: Experience from a Tertiary Care Pediatric Dermatology Clinic

AlKharafi, Najla N. A. H.; Alsaeid, A.B.P. Khaled; AlSumait, Anwar; Al‐Sabah, Humoud; Al-Ajmi, Hejab; Rahim, Jasim Abdul; Alenezi, Hamid Al; Nanda, Arti

doi:10.1111/pde.12788

Cited by 19 publications

(18 citation statements)

References 32 publications

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“…12 Our finding is also similar to another study of cutaneous lupus erythematosus in children. 13 Infantile hemangioma was also more prevalent in female than in male patients, which is consistent with the overall hemangioma data from previous studies conducted in various regions worldwide. [14][15][16][17][18] Cutaneous infections were found in 60/ 769 (7.8%) patients.…”

Section: Discussionsupporting

confidence: 90%

Common misdiagnoses and prevalence of dermatological disorders at a pediatric tertiary care center

2019

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Objectives Dermatological disorders are common in general pediatric practice. This study aimed to examine common skin problems and the manner in which they tend to be misdiagnosed. Methods A cross-sectional study was conducted from January 2015 to December 2016 using medical record data from the Pediatric Dermatological Outpatient Unit at Khon Kaen University, Faculty of Medicine. Results A total of 1551 visits by 769 patients were documented during the study period. A total of 114 presenting diseases were recorded. The most common skin disease in the study population was dermatitis (unspecified) (88/769, 11.4%), followed by atopic dermatitis (76/769, 9.8%) and infantile hemangioma (72/769, 9.3%). There was a total of 55 (48.2%) misdiagnosed diseases. Some unique cutaneous diseases were undiagnosed because of their rarity. However, the percentages of common cutaneous diseases, such as tinea capitis and molluscum contagiosum, which had been misdiagnosed, were also high (62.50% [95% confidence interval = 24.49–91.48] and 71.43% [95% confidence interval = 29.04–96.33], respectively). Conclusion A large percentage of misdiagnoses of common cutaneous diseases may be due to general pediatricians being undereducated in the field of dermatology. Accurate recognition and appropriate management of these conditions should be emphasized for educating general pediatricians in the future.

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Section: Discussionsupporting

confidence: 90%

Common misdiagnoses and prevalence of dermatological disorders at a pediatric tertiary care center

2019

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“…Both patients with BLE (Cases 20, 21) were diagnosed with systemic lupus erythematosus (SLE). Case 20 15 1998-2012 (15) 1976-2007 (31) 1983-2000 (17) 1991-1994 31981-1997 (16) Place of study Table 2 summarizes and compares our data to that of prior series in the English literature. [4][5][6][7][8][9][10] Similar to the majority of prior series, LABD was the most prevalent AIBD in our cohort, occurred more commonly in male children, and was most often treated with dapsone alone or in combination with prednisolone.…”

Section: Labd Cases (Cases 1-16) Included 12 Boys and 4 Girls (M:f Ratiomentioning

confidence: 99%

Spectrum of autoimmune bullous diseases among children in Kuwait

Nanda¹,

Lazarevic²,

Rajy³

et al. 2020

Pediatric Dermatology

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Autoimmune bullous diseases (AIBD) comprise a group of disorders in which autoantibodies target structural proteins of the intracellular junctions of the skin and mucous membranes or dermal-epidermal junction, leading to bullae formation. They are divided into intraepidermal AIBD, which include pemphigus vulgaris (PV) and its variants, and subepidermal AIBD, which include bullous pemphigoid (BP), mucous membrane pemphigoid (MMP), linear IgA bullous disease (LABD), dermatitis herpetiformis (DH), epidermolysis bullosa acquisita (EBA), bullous lupus erythematosus (BLE), and lichen planus pemphigoides (LPP). Among them, LABD and DH are most often reported in children, while others are uncommonly seen. 1-5 Data describing the spectrum of AIBD among children are scarce. 4-10 Due to

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“…84 Over 70% of children with SLE have skin findings, which are the presenting feature in up to a third. [84][85][86] Studies suggest that children with cutaneous LE are more likely to meet criteria for SLE than adults. 84,85 The lupus-specific cutaneous manifestations are varied.…”

Section: Cutaneous Lementioning

confidence: 99%

“…[84][85][86] Studies suggest that children with cutaneous LE are more likely to meet criteria for SLE than adults. 84,85 The lupus-specific cutaneous manifestations are varied. ACLE presents with the typical ''butterfly'' malar rash and/or a generalized photodistributed eruption and often signals underlying systemic disease.…”

Section: Cutaneous Lementioning

confidence: 99%

Histopathology of Cutaneous Inflammatory Disorders in Children

Hsi

Rosman

2018

Pediatr Dev Pathol

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Inflammatory dermatoses encompass a variety of histologic patterns that affect different portions of the skin. In spongiotic, psoriasiform, lichenoid, pityriasiform, and blistering disorders, there are predominately epidermal and junctional activities with variable superficial dermal inflammation. Hypersensitivity reactions can show either epidermal or mostly dermal changes depending on whether the exposure of the exogenous allergen occurs through an external or internal route, respectively. Exceptions include erythema multiforme and Stevens-Johnson syndrome/toxic epidermal necrolysis, where the etiology is often due to infection or ingested medications, but the histologic features are almost exclusively confined to the epidermis and dermoepidermal junction. Autoimmune disorders are unique in that lesions typically incorporate a mixture of epidermal and dermal inflammatory patterns with periadnexal inflammation, while the vast majority of vasculitis/vasculopathy and alopecia have changes limited to only the vessels and hair follicles, respectively. It is critical to recognize that a relatively limited number of histologic patterns are seen in a large array of clinical entities. Therefore, clinicopathologic correlation and careful examination of histologic details are of the utmost importance when evaluating skin biopsies for inflammatory disorders.

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Cutaneous Lupus Erythematosus in Children: Experience from a Tertiary Care Pediatric Dermatology Clinic

Cited by 19 publications

References 32 publications

Common misdiagnoses and prevalence of dermatological disorders at a pediatric tertiary care center

Common misdiagnoses and prevalence of dermatological disorders at a pediatric tertiary care center

Spectrum of autoimmune bullous diseases among children in Kuwait

Histopathology of Cutaneous Inflammatory Disorders in Children

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