2015
DOI: 10.1590/abd1806-4841.20153334
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Bullous pemphigoid and neurological disease: statistics from a dermatology service

Abstract: Bullous pemphigoid (BP) is an autoimmune, acquired, cutaneous disease caused by the production of autoantibodies against hemidesmosomes' components in the basement membrane. The estimated incidence in Europe ranges from 7 to 43 cases per million inhabitants per year. Several studies have reported an association between BP and neurological disorders (ND). Our cohort of Bullous pemphigoid and ND is the first in Brazil and showed a significantly high prevalence of neurological and/or psychiatric diseases, especia… Show more

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Cited by 34 publications
(37 citation statements)
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“…In part, this may be due to the age of the BP patients, which in recent studies ranged from 64 to 83 years. [14][15][16]18,19,21,25 We observed that dementia was the most prevalent neurological disorder in patients with BP (32%). This association is in line with Kwan et al 20 who conducted a retrospective case-control study on 43 patients with BP and reported that dementia was the only neurological disorder that had any statistically significant association (P = 0.002) with this autoimmune disease.…”
Section: Discussionmentioning
confidence: 84%
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“…In part, this may be due to the age of the BP patients, which in recent studies ranged from 64 to 83 years. [14][15][16]18,19,21,25 We observed that dementia was the most prevalent neurological disorder in patients with BP (32%). This association is in line with Kwan et al 20 who conducted a retrospective case-control study on 43 patients with BP and reported that dementia was the only neurological disorder that had any statistically significant association (P = 0.002) with this autoimmune disease.…”
Section: Discussionmentioning
confidence: 84%
“…It has previously been shown that the incidence of cerebrovascular accident (CVA) and dementia in patients with BP is significantly elevated. 18 Tarazone et al 19 also revealed a significantly greater prevalence of neurological disorders, especially CVA and dementia, in patients with BP. With 9%, stroke was the second most common neurological disorder in patients with BP, with a highly statistically significant association (P = 0.0015).…”
Section: Discussionmentioning
confidence: 94%
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“…Bullous pemphigoid is an acquired, autoimmune disease confi ned to the skin, characterized by formation of autoantibodies which are directed towards components of hemidesmosomes in the basement membrane (5). It is the most common autoimmune bullous disease in Western Europe and North America (6), and probably in most countries of the world (5), which aff ects mostly the elderly (7).…”
Section: Discussionmentioning
confidence: 99%
“…This association has been studied in case‐control, case series, and large population based studies. These studies have spanned extensive and diverse geographical territories including North America, South America, Western Europe, Eastern Europe, and Asia . The prevalence of neurologic disease is significantly greater in patients with BP when compared with control populations, and it is estimated to be between 28% and 56% according to multiple studies .…”
Section: Bp and Neurologic Diseasementioning
confidence: 99%