Bullous eosinophilic annular erythema

Eosinophilic annular erythema is clinically characterized by central pigmentation reflecting basal melanosis: a clinicopathological study of 10 cases

“…The male:female ratio of EAE was 3 : 7 in our cases and 13 : 15 in previous reports; there is a slight predominance in females . The reason is yet to be elucidated, but three EAE female cases had a history of autoimmune disorders in our study.…”

“…As stated in the first report of eosinophilic annular erythema (EAE), the entity of EAE was proposed to describe annular skin lesions associated with tissue eosinophilia . To date, 25 cases of EAE have been reported in the English literature . EAE is characterized by the appearance of persistent annular or figurate lesions, a chronic course with recurrent relapse and recalcitrance to various treatments .…”

Bullous eosinophilic annular erythema

“…Eosinophilic annular erythema presents with annular, figurate urticarial edematous plaques primarily affecting the trunk and proximal limbs. A bullous variant has also been reported [1], as with our patient. We postulate that this clinical variant may result from an intense inflammatory infiltrate and dermal edema.…”

“…Reported treatment for this condition includes corticosteroids [1][2][3], antimalarial drugs [3,5], dapsone, indomethacin [4], cyclosporine [6] and Dermatology Online Journal || Photo Vignette dupilumab [7]. Our patient responded well to potent topical corticosteroids.…”

“…Our patient responded well to potent topical corticosteroids. A chronic relapsing-remitting nature of this condition has been well documented in literature [1][2][3][4], with the largest case series of 10 patients reporting an average of four to 7 months' duration for a relapse of the condition [3]. Ideally, all patients should be on follow-up for recurrence.…”