Bullous Darier’s disease mimicking Hailey-Hailey disease

Abstract

BackgroundThe bullous variant of Darier’s disease (DD) is a rare type characterized by histological and clinical overlap with Hailey-Hailey disease (HDD).Case reportsThe following case report describes two cases of familial DD; a 51-year-old woman who presented with erythematous plaques, covered by small blisters in axillary and inguinal areas, and the first patient’s daughter, who presented with keratotic papules localized on the axillary and inframammary folds.ConclusionThese two cases are original by the predominant flexural distribution, and by a bullous form in the first case, clinically and histologically mimicking HHD.

Exacerbation of Darier’s disease with COVID-19

“…A rare vesiculobullous variant of DD has been reported in the literature and should be considered when vesicular lesions are seen. 7 We emphasize the case of a patient with DD who developed an exacerbation with papulo-vesicular lesions who did not have the vesiculo-bullous variant of Darier's disease and for whom testing for herpes viral infections was negative. The flare occurred concurrent with a COVID-19 infection and then recurred 1 year later with a second COVID-19 infection.…”

Vesicular Darier’s disease: a case report and review of the English literature of a rare disease variant

“…A comprehensive literature search was performed, which revealed a total of 26 case reports that described cases of vesicular Darier’s disease via search of title and/or abstract. 3 – 28 A list of 16 case reports that were accessible in English is summarized in Table 1 .…”