Exacerbation of Darier’s disease with COVID-19

Dykes, Rachel; Martin, Taylor; Ergen, Elizabeth N.; Coleman, Neil M.

doi:10.1016/j.jdcr.2022.06.037

Cited by 3 publications

(5 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…12 Therefore, although the general theory that COVID-19-related DD exacerbations are related to the activation of cytokine networks, including those of proinflammatory cytokines, is likely correct, the exact inflammatory mechanism by which this occurs remains to be investigated. vaccination-related exacerbation of DD (Table 1), [7][8][9] although there are no reports of both episodes of DD exacerbation occurring in the same patient, to the best of our knowledge. Although we cannot completely exclude the possibility that the exacerbation was a coincidence, we think it unlikely that the two episodes of exacerbation simply happened to occur at the time of the two independent COVID-19-related events: COVID-19 infection and COVID-19 vaccination.…”

Section: Discussionmentioning

confidence: 98%

“…However, few case reports have linked COVID‐19 infection and DD exacerbation 7,8 (Table 1). Recently, Elbæk et al 9 reported an association between COVID‐19 vaccination and DD exacerbation (Table 1), where they postulate that increased cytokine levels following vaccination play a role.…”

Section: Discussionmentioning

confidence: 99%

“…Our case is particularly interesting, as one patient had two independent episodes of COVID‐19‐related exacerbation of DD lesions: one after infection, and the other after vaccination. Very recently, a few reports have been published on the COVID‐19 infection‐ and vaccination‐related exacerbation of DD (Table 1), 7–9 although there are no reports of both episodes of DD exacerbation occurring in the same patient, to the best of our knowledge. Although we cannot completely exclude the possibility that the exacerbation was a coincidence, we think it unlikely that the two episodes of exacerbation simply happened to occur at the time of the two independent COVID‐19‐related events: COVID‐19 infection and COVID‐19 vaccination.…”

Section: Discussionmentioning

confidence: 99%

“…3 In addition, COVID-19 vaccinations from every manufacturer have been reported to exacerbate various dermatological conditions and a number of chronic autoimmune conditions have been reported to be irritated. [4][5][6] However, few case reports have linked COVID-19 infection and DD exacerbation 7,8 (Table 1). Recently, Elbaek et al 9 reported an association between COVID-19 vaccination and DD exacerbation (Table 1), where they postulate that increased cytokine levels following vaccination play a role.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

COVID‐19 infection‐ and vaccination‐related exacerbation of Darier's disease in a single patient

Fukaura

Takeichi

Ebata

et al. 2023

The Journal of Dermatology

View full text Add to dashboard Cite

Darier's disease (DD) is a rare autosomal dominant genodermatosis that results from a pathogenic variant in ATP2A2, the gene that encodes sarco/endoplasmic reticulum ATPase type 2 (SERCA2). 1 Patients usually present with keratotic eruptions in the seborrheic regions that may be vesicular or pustular and are associated with itching and discomfort. Acantholytic dyskeratosis is the characteristic histological feature. Treatment usually involves oral retinoids, which are considered symptomatic rather than curative. 2 DD could be considered a relapsing-remitting disease, and exacerbations are known to occur. Common triggers include heat, sweat, and physical trauma, such as from clothing. Here, we suggest that both COVID-19 infection and COVID-19 vaccination should be considered other common and timely triggers for DD exacerbation. | C A SEA previously healthy 30-year-old man presented to the dermatology clinic with a rash. The patient had noticed slight eruptions about 7 years prior, but was not particularly concerned. However, 6 months before he presented to our clinic this time, his skin eruptions exacerbated and increased in number and size just after his second COVID-19 vaccination (mRNA-1273/Spikevax, Moderna), and he had erythematous maculopapular lesions in large areas of the trunk and extremities. 18 months later, he unfortunately developed a COVID-19 infection, after which his skin symptoms worsened again.Clinical examination found large areas of the upper chest, back, neck, nape, and shins to be affected with erythematous maculopapular eruptions (Figure 1a-c). The papules were approximately 2 mm in diameter and were hyperkeratotic and pigmented. Tiny pustules were also seen.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

COVID‐19 infection‐ and vaccination‐related exacerbation of Darier's disease in a single patient

Fukaura

Takeichi

Ebata

et al. 2023

The Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…These pro-inflammatory cytokines and cellular immune responses can further disrupt calcium homeostasis, exacerbating the underlying pathophysiological mechanisms of DD through acantholysis and apoptosis. [18] However, further research is needed to fully understand the precise mechanisms by which COVID-19 affects the course of DD.…”

Section: Discussionmentioning

confidence: 99%

Identification of a novel nonsense ATP2A2 gene variant in a patient with Darier’s disease flare following COVID-19 infection: A case report

Liu,

Zheng,

et al. 2024

Medicine

View full text Add to dashboard Cite

Rationale: Darier disease (DD) is a rare autosomal dominant disorder that primarily manifests as hyperkeratotic papules and itching. The underlying etiology of DD is pathogenic variation in the ATP2A2 gene. However, this disease has a high penetrance but variable expressivity, indicating that patients inheriting the genotype may have different manifestations due to exogenous factors. Meanwhile, a few reports have documented that COVID-19 may be implicated in the flare of DD. Patient concerns: A 51-year-old man presented with keratotic papules and scaly erythematous rash on his trunk with pruritus after being infected with COVID-19. Laboratory test results were normal. Histological analysis revealed epidermal hyperkeratosis and intraepidermal lacunae containing dyskeratinized cells. Genetic analysis revealed a novel variant of ATP2A2 (c.815G>A, p.Trp272*), which was considered pathogenic in this case. Diagnoses: The patient was diagnosed as having DD. Interventions: Oral acitretin and topical corticosteroid hormone ointments were used. Outcomes: The patient achieved complete resolution of symptoms during the 3-month follow-up period. Lessons: We revealed the first novel ATP2A2 variant (c.815G>A, p.Trp272*) in the flare of DD following COVID-19 infection. Additionally, this pathogenic variant enriches the ATP2A2 gene mutation spectrum.

show abstract