Bullous amyloidosis. A case report

Chow, C.

doi:10.1001/archderm.95.6.622

Cited by 6 publications

(1 citation statement)

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“…Nail changes, including brittleness, crumbling, subungual striations and partial or complete anonychia, may be the initial and sometimes the sole presenting physical abnormality, and are reviewed elsewhere in the current issue of this journal (Breathnach, Wilkinson & Black, 1979). Bullous lesions consequent upon shearing within extensive intradermal amyloid deposits may occur on skin and mucous membranes (Chow & Burns, 1967;Northover et al, 1972), or be confined to oral mucous membrane. In some cases of systemic amyloidosis bullae were largely confined to the dorsum of the hands and closely simulated porphyria cutanea tarda (Hunter, 1976).…”

Section: Clinical Presentationmentioning

confidence: 99%

Systemic amyloidosis and the skin: a review with special emphasis on clinical features and therapy

Breathnach

Black

1979

Clinical and Experimental Dermatology

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Summary This report is a review of the literature on systemic amyloidosis and concentrates largely on primary and plasma cell dyscrasia‐related disease. Recent developments in the fields of amyloid structure and pathogenesis arc discussed and patterns of clinical presentation are described. It is emphasized that a combination of the carpal tunnel syndrome, macroglossia and specific mucocutaneous lesions necessitates an intensive search for an underlying plasma cell dyscrasia, and that immunodectrophoresis of serum and concentrated urine is essential to exclude a paraproteinaemia. Other diagnostic measures, including cutaneous histopathology, are considered. Despite the advances in our understanding of the pathogenesis of amyloid, there has been little progress in terms of the success of therapy, and the ultimate prognosis of patients with systemic amyloidosis remains poor.

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Section: Clinical Presentationmentioning

confidence: 99%

Systemic amyloidosis and the skin: a review with special emphasis on clinical features and therapy

Breathnach

Black

1979

Clinical and Experimental Dermatology

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Familial Lichen Amyloidosis.

Rajagopalan¹,

Ch²

1972

Br J Dermatol

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Summary.— Nineteen members in 4 successive generations of one Chinese family in Malaysia were found to have classical lichen amyloidosis without systemic amyloid involvement. The disease was transmitted as an autosomal dominant trait with variable penetrance. Sex ratio was equal and the onset was around the age of puberty. The extent and severity of the lesions tended to increase with age. No patient subsequently developed the systemic form of amyloidosis. The present findings further strengthen the genetic theory of lichen amyloidosis.

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