Bulleidia extructa: An underappreciated anaerobic pathogen

Morgan, Margie; Ej, Goldstein

doi:10.1016/j.anaerobe.2021.102339

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…Ruminococcus is responsible for the degradation of the mucus layer. Polysaccharides are accountable for the induction of dendritic cells, promoting an inflammatory condition ( 33 , 34 ). Prevotella promotes chronic mucosal inflammation by inducing the TH17 immune response.…”

Section: Discussionmentioning

confidence: 99%

Predictive association of gut microbiome and NLR in anemic low middle-income population of Odisha- a cross-sectional study

Venugopal,

Khan,

Dash

et al. 2023

Front. Nutr.

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BackgroundIron is abundant on earth but not readily available for colonizing bacteria due to its low solubility in the human body. Hosts and microbiota compete fiercely for iron. <15% Supplemented Iron is absorbed in the small bowel, and the remaining iron is a source of dysbiosis. The gut microbiome signatures to the level of predicting anemia among low-middle-income populations are unknown. The present study was conducted to identify gut microbiome signatures that have predictive potential in association with Neutrophil to lymphocytes ratio (NLR) and Mean corpuscular volume (MCV) in anemia.MethodsOne hundred and four participants between 10 and 70 years were recruited from Odisha’s Low Middle-Income (LMI) rural population. Hematological parameters such as Hemoglobin (HGB), NLR, and MCV were measured, and NLR was categorized using percentiles. The microbiome signatures were analyzed from 61 anemic and 43 non-anemic participants using 16 s rRNA sequencing, followed by the Bioinformatics analysis performed to identify the diversity, correlations, and indicator species. The Multi-Layered Perceptron Neural Network (MLPNN) model were applied to predict anemia.ResultsSignificant microbiome diversity among anemic participants was observed between the lower, middle, and upper Quartile NLR groups. For anemic participants with NLR in the lower quartile, alpha indices indicated bacterial overgrowth, and consistently, we identified R. faecis and B. uniformis were predominating. Using ROC analysis, R. faecis had better distinction (AUC = 0.803) to predict anemia with lower NLR. In contrast, E. biforme and H. parainfluenzae were indicators of the NLR in the middle and upper quartile, respectively. While in Non-anemic participants with low MCV, the bacterial alteration was inversely related to gender. Furthermore, our Multi-Layered Perceptron Neural Network (MLPNN) models also provided 89% accuracy in predicting Anemic or Non-Anemic from the top 20 OTUs, HGB level, NLR, MCV, and indicator species.ConclusionThese findings strongly associate anemic hematological parameters and microbiome. Such predictive association between the gut microbiome and NLR could be further evaluated and utilized to design precision nutrition models and to predict Iron supplementation and dietary intervention responses in both community and clinical settings.

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Section: Discussionmentioning

confidence: 99%

Predictive association of gut microbiome and NLR in anemic low middle-income population of Odisha- a cross-sectional study

Venugopal,

Khan,

Dash

et al. 2023

Front. Nutr.

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“…The comparative analysis of the two reveals that the genus Bulleidia and Corynebacterium were the indicators of SOFT samples. According to Morgan and Goldstein (2021) , Bulleidia is an important dental pathogen and can cause distant site infections (e.g. prosthetic joints).…”

Section: Discussionmentioning

confidence: 99%

Distinctive microbiota distribution from healthy oral to post-treatment apical periodontitis

Zhang

Yun

Lin

et al. 2022

Front. Cell. Infect. Microbiol.

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Post-treatment apical periodontitis (PoAP) occurs when root canal treatment has not adequately eliminated bacterial invasion and infection. Yet little is known about the bacterial composition and changes related to the etiology and pathogenesis of PoAP. In this study, clinical samples classified as root apex (HARD) and periapical granulation tissues (SOFT) were separately collected from 10 patients with PoAP. The microbiota of each sample was characterized by 16S rRNA gene sequencing, and the obtained dataset was coanalyzed with 20 NCBI sequence read archive (SRA) datasets of healthy oral (HO) and primary apical periodontitis (PAP). We observed 2522 operational taxonomic units (OTUs) belonging to 29 phyla, and all samples shared 86.5% of the sequence reads. The OTUs affiliated with Bacteroidetes, Firmicutes, Proteobacteria, Fusobacteria, and Actinobacteria, were identified as core microbiota, which accounted for nearly 90% of 16S rRNA sequences in all samples. However, the principal coordinates analysis (PCoA) of the beta diversity demonstrated that the three periapical statuses have distinct microbial compositions. Compared with HO and PoAP, Actinomyces has a significantly increased abundance in PAP. The microbial diversities in PoAP were significantly lower than those in the HO and PAP (p<0.05). The relative abundance of most bacterial taxa was decreasing, except that Clostridia and Synergistia were increased. Furthermore, we explored the potential metabolic differences of the microbial communities by KEGG pathway prediction. We revealed that the microbiota of PoAP might have a more active metabolic capacity, including carbohydrate metabolism, energy metabolism, and enzyme cofactor/carrier biosynthesis (p<0.05). Our study revealed that invasion of opportunistic pathogens such as Clostridia and Synergistia might play a significant role in PoAP, thus guiding the further study of complex microbial-host interactions and the development of more effective diagnostic and therapeutic methods.

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Association of serum homocysteine levels with intestinal flora and cognitive function in schizophrenia

Zhu

et al. 2023

Journal of Psychiatric Research

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Bulleidia extructa: An underappreciated anaerobic pathogen

Cited by 5 publications

References 20 publications

Predictive association of gut microbiome and NLR in anemic low middle-income population of Odisha- a cross-sectional study

Predictive association of gut microbiome and NLR in anemic low middle-income population of Odisha- a cross-sectional study

Distinctive microbiota distribution from healthy oral to post-treatment apical periodontitis

Association of serum homocysteine levels with intestinal flora and cognitive function in schizophrenia

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