Association of serum homocysteine levels with intestinal flora and cognitive function in schizophrenia

Li, Hehua; Li, Hanqiu; Zhu, Zhaojie; Xiong, Xiang; Huang, Yuanyuan; Feng, Yangdong; Li, Zhezhi; Wu, Kai; Wu, Fengchun

doi:10.1016/j.jpsychires.2023.01.045

Cited by 8 publications

(2 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many studies have found higher plasma homocysteine level in patients with schizophrenia than in healthy controls [ 12 , 24 ]. Homocysteine is a component of one-carbon metabolism, contributing a methyl group for methionine synthesis.…”

Section: Discussionmentioning

confidence: 99%

Associations among plasma markers for N-methyl-d-aspartate receptor hypofunction, redox dysregulation, and insufficient myelination in patients with schizophrenia

Isomura,

Ohno,

Sudo

et al. 2024

Heliyon

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Associations among plasma markers for N-methyl-d-aspartate receptor hypofunction, redox dysregulation, and insufficient myelination in patients with schizophrenia

Isomura,

Ohno,

Sudo

et al. 2024

Heliyon

View full text Add to dashboard Cite

“…However, the abnormal up-regulation of Lactobacillus abundance can lead to excessive production of lactate, resulting in the accumulation of lactate in the brain. This disrupts mitochondrial energy regulation balance and triggers a series of mental disorders ( 66 ). Additionally, it was found that the abundance level of Lactobacillus is negatively correlated with the concentration of butyric acid in SCFAs ( 67 ).…”

Section: Discussionmentioning

confidence: 99%

Alterations of the gut microbiota in patients with schizophrenia

Li,

Tao,

Wang

et al. 2024

Front. Psychiatry

View full text Add to dashboard Cite

IntroductionSchizophrenia is a complex psychiatric disorder, of which molecular pathogenesis remains largely unknown. Accumulating evidence suggest that gut microbiota may affect brain function via the complex gut-brain axis, which may be a potential contributor to schizophrenia. However, the alteration of gut microbiota showed high heterogeneity across different studies. Therefore, this study aims to identify the consistently altered gut microbial taxa associated with schizophrenia.MethodsWe conducted a systematic search and synthesis of the up-to-date human gut microbiome studies on schizophrenia, and performed vote counting analyses to identify consistently changed microbiota. Further, we investigated the effects of potential confounders on the alteration of gut microbiota.ResultsWe obtained 30 available clinical studies, and found that there was no strong evidence to support significant differences in α-diversity and β-diversity between schizophrenic patients and healthy controls. Among 428 differential gut microbial taxa collected from original studies, we found that 8 gut microbial taxa were consistently up-regulated in schizophrenic patients, including Proteobacteria, Gammaproteobacteria, Lactobacillaceae, Enterobacteriaceae, Lactobacillus, Succinivibrio, Prevotella and Acidaminococcus. While 5 taxa were consistently down-regulated in schizophrenia, including Fusicatenibacter, Faecalibacterium, Roseburia, Coprococcus and Anaerostipes.DiscussionThese findings suggested that gut microbial changes in patients with schizophrenia were characterized by the depletion of anti-inflammatory butyrate-producing genera, and the enrichment of certain opportunistic bacteria genera and probiotics. This study contributes to further understanding the role of gut microbiota in schizophrenia, and developing microbiota-based diagnosis and therapy for schizophrenia.

show abstract

Positive association between increased homocysteine and deficit syndrome in Chinese patients with chronic schizophrenia: a large-scale cross-sectional study

Peng,

Wang,

Wang

et al. 2023

Eur Arch Psychiatry Clin Neurosci

View full text Add to dashboard Cite

Association of serum homocysteine levels with intestinal flora and cognitive function in schizophrenia

Cited by 8 publications

References 78 publications

Associations among plasma markers for N-methyl-d-aspartate receptor hypofunction, redox dysregulation, and insufficient myelination in patients with schizophrenia

Associations among plasma markers for N-methyl-d-aspartate receptor hypofunction, redox dysregulation, and insufficient myelination in patients with schizophrenia

Alterations of the gut microbiota in patients with schizophrenia

Positive association between increased homocysteine and deficit syndrome in Chinese patients with chronic schizophrenia: a large-scale cross-sectional study

Contact Info

Product

Resources

About