Bulbine frutescens phytochemical inhibits notch signaling pathway and induces apoptosis in triple negative and luminal breast cancer cells

Kushwaha, Prem Prakash; Vardhan, Pothabathula Sheshu; Kapewangolo, Petrina T.; Mohammad, Sameer; Prajapati, Sunita Kumari; Singh, Atul Kumar; Kumar, Shashank

doi:10.1016/j.lfs.2019.116783

Cited by 62 publications

(70 citation statements)

References 29 publications

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“…With the deepening of research, it is believed that more natural products that can regulate the mitochondria have the potential to be used in treating diseases, which is of utmost importance. Oxidative Medicine and Cellular Longevity [44] Oxidative stress Bulbine frutescens [37] Bullfrog oil [38] Orientin [40] Asparanin A [42] Gracillin [44] Apoptosis Bulbine frutescens [37] Orientin [40] Licochalcone A [41] Asparanin A [42] Parameritannin A-2 [43] Cernumidine [45] Mitochondrial membrane potential imbalance Bullfrog oil [38] Rhein [39] Asparanin A [42] Cernumidine [45] Neurodegenerative diseases…”

Section: Resultsmentioning

confidence: 99%

Remedying the Mitochondria to Cure Human Diseases by Natural Products

Shi

et al. 2020

Oxidative Medicine and Cellular Longevity

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Mitochondria are the ‘engine’ of cells. Mitochondrial dysfunction is an important mechanism in many human diseases. Many natural products could remedy the mitochondria to alleviate mitochondria-involved diseases. In this review, we summarized the current knowledge of the relationship between the mitochondria and human diseases and the regulation of natural products to the mitochondria. We proposed that the development of mitochondrial regulators/nutrients from natural products to remedy mitochondrial dysfunction represents an attractive strategy for a mitochondria-involved disorder therapy. Moreover, investigating the mitochondrial regulation of natural products can potentiate the in-depth comprehension of the mechanism of action of natural products.

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Section: Resultsmentioning

confidence: 99%

Remedying the Mitochondria to Cure Human Diseases by Natural Products

Shi

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…IGC-001, a β-Cantenin/ T Cell Factor mediated transcription antagonist, downregulates survivin expression leading to selective caspase activation in tumor cells [179]. Silencing Notch, using peptide antibiotic echinomycin, natural phytochemicals Xanthohumol and Bulbine frutescens, silences survivin in breast, ovary, liver and cholangiocarcinoma and has significant effects on stemness [180,181]. Other small molecules including Bay-11-7057, AKAP145, Metformin, Phenformin, GDP366, etc.…”

Section: Inhibitors Targeting Signaling Pathwaysmentioning

confidence: 99%

Emerging Importance of Survivin in Stem Cells and Cancer: the Development of New Cancer Therapeutics

Warrier

Agarwal

Kumar

2020

Stem Cell Rev and Rep

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Survivin is one of the rare proteins that is differentially expressed in normal and cancer cells and is directly or indirectly involved in numerous pathways required for tumor maintenance. It is expressed in almost all cancers and its expression has been detected at early stages of cancer. These traits make survivin an exceptionally attractive target for cancer therapeutics. Even with these promising features to be an oncotherapeutic target, there has been limited success in the clinical trials targeting survivin. Only recently it has emerged that survivin was not being specifically targeted which could have resulted in the negative clinical outcome. Also, focus of research has now shifted from survivin expression in the overall heterogeneous tumor cell populations to survivin expression in cancer stem cells as these cells have proved to be the major drivers of tumors. Therefore, in this review we have analyzed the expression of survivin in normal and cancer cells with a particular focus on its expression in cancer stem cell compartment. We have discussed the major signaling pathways involved in regulation of survivin. We have explored the current development status of various types of interventions for inhibition of survivin. Furthermore, we have discussed the challenges involving the development of potent and specific survivin inhibitors for cancer therapeutics. Finally we have given insights for some of the promising future anticancer treatments.

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“…Accumulating research demonstrates that medicinal plants possess therapeutic potential against microbes and pathogen [ [7] , [8] , [9] ]. Recent reports suggest that natural-like products and their metabolites present in several plant spices exhibit remarkable potential to block SARS-CoV-2 M pro receptor [ [10] , [11] , [12] ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemicals present in Indian ginseng possess potential to inhibit SARS-CoV-2 virulence: A molecular docking and MD simulation study

Kushwaha

Singh

Prajapati

et al. 2021

Microbial Pathogenesis

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Coronaviruses are deadly and contagious pathogens that affects people in different ways. Researchers have increased their efforts in the development of antiviral agents against coronavirus targeting M pro protein (main protease) as an effective drug target. The present study explores the inhibitory potential of characteristic and non-characteristic Withania somnifera (Indian ginseng) phytochemicals (n ≈ 100) against SARS-Cov-2 M pro protein. Molecular docking studies revealed that certain W. somnifera compounds exhibit superior binding potential (−6.16 to −12.27 kcal/mol) compared to the standard inhibitors (−2.55 to −6.16 kcal/mol) including nelfinavir and lopinavir. The non-characteristic compounds (quercetin-3-rutinoside-7-glucoside, rutin and isochlorogenic acid B) exhibited higher inhibitory potential in comparison to characteristic W. somnifera compounds withanolide and withanone. Molecular dynamics (MD) simulation studies of the complex for 100 ns confirm favorable and stable binding of the lead molecule. The MMPBSA calculation of the last 10 ns of the protein-ligand complex trajectory exhibited stable binding of quercetin-3-rutinoside-7-glucoside at the active site of SARS-Cov-2 M pro . Taken together, the study demonstrates that the non-characteristic compounds present in W. somnifera possess enhanced potential to bind SARS-Cov-2 M pro active site. We further recommend in vitro and in vivo experimentation to validate the anti-SARS-CoV-2 potential of these lead molecules.

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Bulbine frutescens phytochemical inhibits notch signaling pathway and induces apoptosis in triple negative and luminal breast cancer cells

Cited by 62 publications

References 29 publications

Remedying the Mitochondria to Cure Human Diseases by Natural Products

Remedying the Mitochondria to Cure Human Diseases by Natural Products

Emerging Importance of Survivin in Stem Cells and Cancer: the Development of New Cancer Therapeutics

Phytochemicals present in Indian ginseng possess potential to inhibit SARS-CoV-2 virulence: A molecular docking and MD simulation study

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