Emerging Importance of Survivin in Stem Cells and Cancer: the Development of New Cancer Therapeutics

Warrier, Neerada Meenakshi; Agarwal, Prasoon; Kumar, Praveen

doi:10.1007/s12015-020-09995-4

Cited by 64 publications

(60 citation statements)

References 260 publications

(294 reference statements)

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“…Consistently, in cancer cells, the Telomerase allows uncontrolled cell proliferation, which is essential for tumor progression (80). Additionally, Survivin, a protein overexpressed in many cancers (81), where it promotes proliferation and inhibits apoptosis, is expressed in trophoblast cells, however its role in this location has not been elucidated yet (82,83). Altogether these studies indicate that the Telomerase and Survivin have an important role in cell proliferation in both trophoblast and cancer cells.…”

Section: Similarities and Differences Between Cancer Cells And Trophoblast Derived Cells Cellular Proliferation Migration And Invasionmentioning

confidence: 93%

Autophagy Process in Trophoblast Cells Invasion and Differentiation: Similitude and Differences With Cancer Cells

et al. 2021

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Early human placental development begins with blastocyst implantation, then the trophoblast differentiates and originates the cells required for a proper fetal nutrition and placental implantation. Among them, extravillous trophoblast corresponds to a non-proliferating trophoblast highly invasive that allows the vascular remodeling which is essential for appropriate placental perfusion and to maintain the adequate fetal growth. This process involves different placental cell types as well as molecules that allow cell growth, cellular adhesion, tissular remodeling, and immune tolerance. Remarkably, some of the cellular processes required for proper placentation are common between placental and cancer cells to finally support tumor growth. Indeed, as in placentation trophoblasts invade and migrate, cancer cells invade and migrate to promote tumor metastasis. However, while these processes respond to a controlled program in trophoblasts, in cancer cells this regulation is lost. Interestingly, it has been shown that autophagy, a process responsible for the degradation of damaged proteins and organelles to maintain cellular homeostasis, is required for invasion of trophoblast cells and for vascular remodeling during placentation. In cancer cells, autophagy has a dual role, as it has been shown both as tumor promoter and inhibitor, depending on the stage and tumor considered. In this review, we summarized the similarities and differences between trophoblast cell invasion and cancer cell metastasis specifically evaluating the role of autophagy in both processes.

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Section: Similarities and Differences Between Cancer Cells And Trophoblast Derived Cells Cellular Proliferation Migration And Invasionmentioning

confidence: 93%

Autophagy Process in Trophoblast Cells Invasion and Differentiation: Similitude and Differences With Cancer Cells

et al. 2021

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“…Survivin (encoded by the BIRC5 gene) is an anti-apoptotic protein often over-expressed in various cancer types and absent or little-expressed in normal cells [55]. Survivin depletion generally promotes tumor cell apoptotic death, and survivin is therefore recognized as an important therapeutic target [55][56][57]. We reported that…”

Section: Bpep and Dpep Deplete Anti-apoptotic Protein Survivin And Reduce Expression Of Direct Atf5 Targets Bcl2 And Mcl1mentioning

confidence: 99%

Cell-Penetrating CEBPB and CEBPD Leucine Zipper Decoys as Broadly Acting Anti-Cancer Agents

Zhou

Sun

Pasquier

et al. 2021

Cancers

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Transcription factors are key players underlying cancer formation, growth, survival, metastasis and treatment resistance, yet few drugs exist to directly target them. Here, we characterized the in vitro and in vivo anti-cancer efficacy of novel synthetic cell-penetrating peptides (Bpep and Dpep) designed to interfere with the formation of active leucine-zipper-based dimers by CEBPB and CEBPD, transcription factors implicated in multiple malignancies. Both peptides similarly promoted apoptosis of multiple tumor lines of varying origins, without such effects on non-transformed cells. Combined with other treatments (radiation, Taxol, chloroquine, doxorubicin), the peptides acted additively to synergistically and were fully active on Taxol-resistant cells. The peptides suppressed expression of known direct CEBPB/CEBPD targets IL6, IL8 and asparagine synthetase (ASNS), supporting their inhibition of transcriptional activation. Mechanisms by which the peptides trigger apoptosis included depletion of pro-survival survivin and a required elevation of pro-apoptotic BMF. Bpep and Dpep significantly slowed tumor growth in mouse models without evident side effects. Dpep significantly prolonged survival in xenograft models. These findings indicate the efficacy and potential of Bpep and Dpep as novel agents to treat a variety of cancers as mono- or combination therapies.

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“…Literature reviews have shown that PI3-K [ 13 – 16 ], survivin [ 17 , 18 ] and MAP-K activation [ 19 , 20 ] are essential for cell proliferation. It is also possible that inhibition of MMP20 may inactivate the WNT / ß-catenin signalling pathway [ 19 ] leading to reduction in cell proliferation.…”

Section: 0 Discussionmentioning

confidence: 99%

Lung development, repair and cancer: A study on the role of MMP20 gene in adenocarcinoma

et al. 2021

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Multiple matrix metalloproteinases have significant roles in tissue organization during lung development, and repair. Imbalance of proteinases may lead to chronic inflammation, changes in tissue structure, and are also highly associated to cancer development. The role of MMP20 is not well studied in lung organogenesis, however, it was previously shown to be present at high level in lung adenocarcinoma. The current study aimed to identify the functional properties of MMP20 on cell proliferation and motility in a lung adenocarcinoma in vitro cell model, and relate the interaction of MMP20 with other molecular signalling pathways in the lung cells after gaining tumoral properties. In this study, two different single guide RNA (sgRNAs) that specifically targeted on MMP20 sites were transfected into human lung adenocarcinoma A549 cells by using CRISPR-Cas method. Following that, the changes of PI3-K, survivin, and MAP-K mRNA gene expression were determined by Real-Time Polymerase Chain Reaction (RT-PCR). The occurrence of cell death was also examined by Acridine Orange/Propidium Iodide double staining. Meanwhile, the motility of the transfected cells was evaluated by wound healing assay. All the data were compared with non-transfected cells as a control group. Our results demonstrated that the transfection of the individual sgRNAs significantly disrupted the proliferation of the A549 cell line through suppression in the gene expression of PI3-K, survivin, and MAP-K. When compared to non-transfected cells, both experimental cell groups showed reduction in the migration rate, as reflected by the wider gaps in the wound healing assay. The current study provided preliminary evidence that MMP20 could have regulatory role on stemness and proliferative genes in the lung tissues and affect the cell motility. It also supports the notion that targeting MMP20 could be a potential treatment mode for halting cancer progression.

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Emerging Importance of Survivin in Stem Cells and Cancer: the Development of New Cancer Therapeutics

Cited by 64 publications

References 260 publications

Autophagy Process in Trophoblast Cells Invasion and Differentiation: Similitude and Differences With Cancer Cells

Autophagy Process in Trophoblast Cells Invasion and Differentiation: Similitude and Differences With Cancer Cells

Cell-Penetrating CEBPB and CEBPD Leucine Zipper Decoys as Broadly Acting Anti-Cancer Agents

Lung development, repair and cancer: A study on the role of MMP20 gene in adenocarcinoma

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