Building an Antifouling Zwitterionic Coating on Urinary Catheters Using an Enzymatically Triggered Bottom-Up Approach

Blanco, Carlos Díaz; Ortner, Andreas; Dimitrov, Radostin; Navarro, Andrés; Mendoza, Ernest; Tzanov, Tzanko

doi:10.1021/am501961b

Cited by 111 publications

(96 citation statements)

References 48 publications

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“…In 2014, Blanco et al found that functionalization of silicone catheters with zwitterionic moieties provided antibiofilm properties to the catheter against P. aeruginosa and S. aureus [175]. The coating was primarily composed of PDMS which was plasma-activated and preaminated.…”

Section: Antimicrobial Urinary Catheter Coating Agents/materials Imentioning

confidence: 99%

A review of the recent advances in antimicrobial coatings for urinary catheters

2017

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More than 75% of hospital-acquired or nosocomial urinary tract infections are initiated by urinary catheters, which are used during the treatment of 15–25% of hospitalized patients. Among other purposes, urinary catheters are primarily used for draining urine after surgeries and for urinary incontinence. During catheter-associated urinary tract infections, bacteria travel up to the bladder and cause infection. A major cause of catheter-associated urinary tract infection is attributed to the use of non-ideal materials in the fabrication of urinary catheters. Such materials allow for the colonization of microorganisms, leading to bacteriuria and infection, depending on the severity of symptoms. The ideal urinary catheter is made out of materials that are biocompatible, antimicrobial, and antifouling. Although an abundance of research has been conducted over the last forty-five years on the subject, the ideal biomaterial, especially for long-term catheterization of more than a month, has yet to be developed. The aim of this review is to highlight the recent advances (over the past 10 years) in developing antimicrobial materials for urinary catheters and to outline future requirements and prospects that guide catheter materials selection and design.

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Section: Antimicrobial Urinary Catheter Coating Agents/materials Imentioning

confidence: 99%

A review of the recent advances in antimicrobial coatings for urinary catheters

2017

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“…Díaz Blanco and co‐workers also employed oxygen plasma to hydroxylate flat poly(dimethylsiloxane) (PDMS; Scheme ) . The hydroxylated surface was then treated with APTES to generate amine‐functionalised PDMS (PDMS‐NH 2 ).…”

Section: Laccase‐mediated Grafting On Synthetic Polymersmentioning

confidence: 99%

Laccase‐Mediated Grafting on Biopolymers and Synthetic Polymers: A Critical Review

2017

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Laccase‐mediated grafting on lignocelluloses has gained considerable attention as an environmentally benign method to covalently modify wood, paper and cork. In recent decades this technique has also been employed to modify fibres with a polysaccharide backbone, such as cellulose or chitosan, to infer colouration, antimicrobial activity or antioxidant activity to the material. The scope of this approach has been further widened by researchers, who apply mediators or high redox potential laccases and those that modify synthetic polymers and proteins. In all cases, the methodology relies on one‐ or two‐electron oxidation of the surface functional groups or of the graftable molecule in solution. However, similar results can very often be achieved through simple deposition, even after extensive washing. This unintended adsorption of the active substance could have an adverse effect on the durability of the applied coating. Differentiating between actual covalent binding and adsorption is therefore essential, but proves to be challenging. This review not only covers excellent research on the topic of laccase‐mediated grafting over the last five to ten years, but also provides a critical comparison to highlight either the lack or presence of compelling evidence for covalent grafting.

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“…Water contact angles of dried films in air were measured under ambient conditions (Â amb ) and saturated water vapor conditions (Â sat ) using a sessile drop method. Air contact angles in water (Â air ) were examined for films immersed in water for 30 min before measurements using a captive bubble method [43][44][45]. All measurements were conducted at room temperature.…”

Section: Film Surface Propertiesmentioning

confidence: 99%