The Smart City (SC) idea has attracted increasing attention due to fast growth of urban centers. SC concepts require more complex and higher quality services for their citizens, most of which are supported by Information and Communication Technologies (ICTs). In order to tackle this emergent topic, different e-government systems and technologies have been used for several urban services, such as mobility, economics, healthcare, education, among others. Such systems can be part of Systems of Systems (SoS), which have an intrinsically challenging developing process due to complex aspects, such as infrastructure issues, data and subsystems integration, and data management in decision support systems (DSS) for all stakeholders. Therefore, the use of innovative technologies must be addressed, and this chapter outlines the general landscape on SC approaches, discussing issues from Information Systems (IS) perspective considering different concepts available in the literature. This work also highlights current and forthcoming challenges for this IS area, including design, implementation and deployment of such systems, as well as a method to evaluate an SC from an IS perspective.