Budesonide and Formoterol in a Single Inhaler Improves Asthma Control Compared With Increasing the Dose of Corticosteroid in Adults With Mild-to-Moderate Asthma

Lalloo, Umesh; Małolepszy, J; Kozma, D; Krofta, K; Ankerst, Jaro; Johansen, B.V.; Thomson, Neil C.

doi:10.1378/chest.123.5.1480

Cited by 124 publications

(87 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…here is no known cure for asthma [1,2]; however, pharmacological intervention has been shown to significantly improve symptoms [3][4][5]. The use of inhaled corticosteroids, long acting b 2 -agonists and a combination of these medications have been shown to improve asthma control [3,4], but compliance rates of .80% are required to maintain this level of control [6].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Exercise is associated with improved asthma control in adults

Dogra¹,

Kuk²,

Baker³

et al. 2010

European Respiratory Journal

106

View full text Add to dashboard Cite

Global asthma control levels are suboptimal. The influence of regular exercise on asthma control is unclear.We assessed the effects of a 12-week supervised exercise intervention followed by 12 weeks of self-administered exercise on adults with partially controlled asthma (n521) and matched controls (n515). Assessments were conducted at baseline and week 12 for both the exercise and control group, and again at week 24 for the exercise group.There was a significant treatment effect on asthma control in the exercise group, as measured by the Asthma Control Questionnaire (ACQ), from baseline to week 12, compared with the control group. A clinically significant improvement (0.5 increase in ACQ score) was observed for asthma quality of life and ACQ in the exercise group from baseline to week 12. There was a significant improvement in aerobic fitness from baseline to week 24 in the exercise group.In conclusion, a 12-week supervised exercise intervention led to improvements in asthma control and quality of life in partially controlled asthmatics motivated to exercise. These improvements were maintained, while aerobic fitness and perceived asthma control significantly improved over an additional 12 weeks of self-administered exercise. These findings indicate that a structured exercise intervention can improve asthma control.

show abstract

mentioning

confidence: 99%

“…The use of inhaled corticosteroids, long acting b 2 -agonists and a combination of these medications have been shown to improve asthma control [3,4], but compliance rates of .80% are required to maintain this level of control [6]. Unfortunately, compliance to asthma treatment in countries where treatment is readily accessible remains poor [7,8].…”

mentioning

confidence: 99%

Exercise is associated with improved asthma control in adults

Dogra¹,

Kuk²,

Baker³

et al. 2010

European Respiratory Journal

106

View full text Add to dashboard Cite

show abstract

“…Twenty citations were retrieved from the databases, of which 13 did not examine asthma exacerbation or aggravation, and 5 did not examine ICS and FOBA combination therapy. Two articles were identi ed from the reference lists of the retrieved studies, giving a total of 4 RCTs for inclusion in the network meta-analysis 4,6,12,13 .…”

Section: Search Results and Characteristics Of Included Studiesmentioning

confidence: 99%

On-demand Inhaled Corticosteroid and Fast-onset Beta-2 Agonist Combination Therapy Versus Conventional Treatment for Mild to Moderate Asthma: A Non-inferiority, Network Meta-analysis

Andō

Tanaka

Yokoe

et al. 2017

Showa Univ J Med Sci

View full text Add to dashboard Cite

: The aim of this study was to assess the non-inferiority of on-demand OD inhaled corticosteroid ICS and fast-onset beta-2 agonist FOBA combination therapy. Although the guidelines recommend regular inhalation of ICS and long-acting beta-2 agonist LABA , we investigated whether OD-ICS / FOBA is as effective as regular inhalation. A network meta-analysis of randomized controlled trials was conducted to inspect the non-inferiority of OD-ICS / FOBA ef cacy compared with conventional best practice, i.e. regular low-to medium-dose ICS with or without LABA, plus OD short-acting beta-2 agonist REG-ICS OD-SABA or REG-ICS / LABA OD-SABA in patients with mild to moderate asthma. PubMed, the Cochrane library database, and Scopus were searched to identify relevant articles. Outcome measures were the incidence of asthma exacerbation or aggravation. A network meta-analysis was performed to estimate risk ratios RRs with 95 con dence intervals CIs and the probability of being the best treatment for the outcome. Four randomized controlled trials of treatment for mild to moderate asthma met the criteria and were included in the study. We could not demonstrate non-inferiority of OD-ICS / FOBA to REG-ICS OD-SABA RR, 1.17 ; 95 CI, 0.61 to 2.26 or to REG-ICS / LABA OD-SABA RR, 1.47 ; 95 CI, 0.79 to 2.71 for mild to moderate asthma. The probability of being the best treatment to reduce asthma exacerbation or aggravation was 10.5 for OD-ICS / FOBA, 10.3 for REG-ICS OD-SABA, and 79.3 for REG-ICS / LABA OD-SABA. Surface under the cumulative ranking SUCRA curves were 0.4, 0.2 and 0.9 for OD-ICS / FOBA, REG-ICS OD-SABA, and REG-ICS / LABA OD-SABA, respectively. Although non-inferiority of OD-ICS / FOBA to conventional best practice was not shown, SUCRA was higher for OD-ICS / FOBA than for REG-ICS OD-SABA. From these results, we propose that OD-ICS / FOBA can be an effective alternative to REG-ICS OD-SABA to reduce asthma exacerbation or aggravation in patients with mild to moderate asthma.

show abstract

“…ICS and ICS/ LABA are used as a first choice for asthma treatment around the world. The effectiveness of ICS and ICS/LABA for asthma treatment is supported in plural large clinical trials [21][22][23][24][25][26][27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Diaphragm Muscle Contraction Decrease in a Mouse Model of Ovalbumin-Induced Allergic Airway Inflammation

Yamaguchi¹,

Shindoh²,

Miura³

2017

J Allergy Ther

View full text Add to dashboard Cite

Objective: We investigated diaphragm contractile and inflammatory properties of mice with OVA sensitization and challenge.Methods: BALB/c mice were sensitized to OVA by intraperitoneal (i.p.) injection at 0 and 7 days, and challenged with aerosolized OVA on 21, 22, and 23 days (O/O group). Budesonide/Formoterol combination was inhaled on days 21, 22, and 23 before OVA challenge on those same days (O/OC group). Control mice were sensitized and challenged with an aerosolized saline (O-group). The diaphragm contractile and inflammatory properties were measured on day 24. NOS activity in the diaphragm muscle was evaluated by NADPH diaphorase staining. IL-4 and IL-13 levels of BALF, as well as lung tissue and diaphragm muscle homogenates were measured by ELISA. Conclusions:OVA sensitization and challenge decreased diaphragm muscle contraction, increased NOS activity, IL-4 levels of diaphragm in a mouse model. Budesonide/Formoterol combination could protect diaphragm muscle weakness and inflammation. According to the traditional concept of the contemporary Immunology, neither autoimmune diseases nor allergic diseases can be cured completely. Nevertheless, a fortunate coincidence led me to discovery of a novel concept that eliminations of the causes of these diseases are possible. In other words, combinations of pathogenic antibodies with responsible cells, namely, cytolytic T lymphocytes in cases of autoimmune diseases and mast cells in cases of allergic diseases, can be decomposed by replacing the pathogenic antibodies with non-specific antibodies. In more detail, intradermal injections with a non-specific antigen preparation induce production of non-specific antibodies in the body of the patient. Repetitions of the injections bring about an accumulation of them. Accumulated non-specific antibodies will occupy most of the receptors on the surface of responsible cells. When the accumulation reaches the sufficient level, virtually no pathogenic antibodies would remain on the receptors. That is, no causes of the diseases remain. Naturally, where there is no cause, there is no disease. Details are demonstrated elsewhere.

show abstract

Budesonide and Formoterol in a Single Inhaler Improves Asthma Control Compared With Increasing the Dose of Corticosteroid in Adults With Mild-to-Moderate Asthma

Cited by 124 publications

References 15 publications

Exercise is associated with improved asthma control in adults

Exercise is associated with improved asthma control in adults

On-demand Inhaled Corticosteroid and Fast-onset Beta-2 Agonist Combination Therapy Versus Conventional Treatment for Mild to Moderate Asthma: A Non-inferiority, Network Meta-analysis

Diaphragm Muscle Contraction Decrease in a Mouse Model of Ovalbumin-Induced Allergic Airway Inflammation

Contact Info

Product

Resources

About