Buckling analysis of polymer microneedle for transdermal drug delivery

Radhika, C.; Gnanavel, B. K.

doi:10.1016/j.matpr.2020.12.397

Cited by 6 publications

(12 citation statements)

References 15 publications

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“…There are different types of variations that affect polymer mechanical properties, such as polymerization process temperature and the incorporation of various copolymers and cross-linkers [ 33 , 34 ]. The mechanical properties of needles and simulated needle failure under compression have been previously investigated [ 35 ]. For example, Du et al determined the mechanical strengths of two types of the hyaluronic acid microneedles with and without drugs; they showed that that polymer molecular weight and amount of loaded drug affected microneedle mechanical behavior [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

Micromolding of Amphotericin-B-Loaded Methoxyethylene–Maleic Anhydride Copolymer Microneedles

et al. 2022

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Biocompatible and biodegradable materials have been used for fabricating polymeric microneedles to deliver therapeutic drug molecules through the skin. Microneedles have advantages over other drug delivery methods, such as low manufacturing cost, controlled drug release, and the reduction or absence of pain. The study examined the delivery of amphotericin B, an antifungal agent, using microneedles that were fabricated using a micromolding technique. The microneedle matrix was made from GantrezTM AN-119 BF, a benzene-free methyl vinyl ether/maleic anhydride copolymer. The GantrezTM AN-119 BF was mixed with water; after water evaporation, the polymer exhibited sufficient strength for microneedle fabrication. Molds cured at room temperature remained sharp and straight. SEM images showed straight and sharp needle tips; a confocal microscope was used to determine the height and tip diameter for the microneedles. Nanoindentation was used to obtain the hardness and Young’s modulus values of the polymer. Load–displacement testing was used to assess the failure force of the needles under compressive loading. These two mechanical tests confirmed the mechanical properties of the needles. In vitro studies validated the presence of amphotericin B in the needles and the antifungal properties of the needles. Amphotericin B GantrezTM microneedles fabricated in this study showed appropriate characteristics for clinical translation in terms of mechanical properties, sharpness, and antifungal properties.

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Section: Resultsmentioning

confidence: 99%

Micromolding of Amphotericin-B-Loaded Methoxyethylene–Maleic Anhydride Copolymer Microneedles

et al. 2022

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“…The critical buckling load for the polycarbonate microneedle is found to be 0.6N [6]. The buckling load measured on titanium microneedle ranged from 0.5 to 1.2N [24].…”

Section: B Theoretical Studymentioning

confidence: 93%

“…Any load applied beyond the critical load will make the microneedle structurally fail. This infers that the load applied on the microneedle should not exceed the critical buckling load [6].…”

Section: Introductionmentioning

confidence: 89%

Post buckling analysis of silicon microneedle

Kumar

Karnal

2021

Preprint

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The microneedle is used to deliver the drug inside the skin structure. During the insertion procedure, the microneedle travel up to the dermis layer through the stratum corneum and epidermis layer. The microneedle have a tendency to critically buckle when the applied load achieves the maximum buckling load. To avoid structural failure of the microneedle, the critical load is identified and safely applied. In this paper, the critical buckling load is identified using the linear and non-linear buckling analysis. The critical load using linear buckling analysis is found to be 263.7µN. The non-linear or post -buckling analysis is performed for the load of 263.7µN and the critical load is found to be 149µN. Thus for silicon microneedle, the critical load is identified as 149µN. Henceforth for silicon microneedle, the applied load should always be smaller than the critical buckling load for safe insertion.

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“…Given before, hollow MNs are presented as an alternative for continuous drug delivery, which opens a channel between the device and the body that allows the administration of higher doses of drugs in comparison of coated MN or dissolving MN, but since they are slender and do not maintain a complete section, they tend to be an important challenge at the structural level, since, they present less resistance to application loads, they propose considerable buckling situations and they are at greater risk of fracture during insertion, which leads to foreign elements producing unwanted inflammatory reactions. [ 1,7,23 ]…”

Section: Introductionmentioning

confidence: 99%

“…The use of computational tools has made it possible to optimize designs through the prediction of specific situations through simulation based on recorded experimental data, which allows the proper selection of materials, geometric parameters, and limit‐operating conditions in fields such as engineering and medicine. [ 18,23–27 ] In this way, the finite‐element method (FEM) stands out as a numerical technique that approximates solutions by means of partial differential equations. With this form of operating, the behavior of complex geometries can be adequately approximated by means of finite subdivisions of the object of study and thus, considerably reduce the risk of fractures, wear or unwanted deformations in a specific design.…”

Section: Introductionmentioning

confidence: 99%

Structural Evaluation by the Finite‐Element Method of Hollow Microneedle Geometries for Drug Delivery

2022

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Herein, the structural comparison, using the finite‐element method (FEM), of different designs of individual hollow microneedles (MNs) is exposed, that is, conical, pyramidal, traditional, and sting type, for use as a transdermal drug delivery system (TDDS). These configurations attract interest in fields such as pharmaceutics and medicine due to their efficiency, easy administration of drugs, and significant reduction in pain compared to the traditional use of hypodermic needles. For the structural analysis and comparison of the proposed designs, ANSYS FEM‐based software is used to simulate the insertion of an MN in the skin. The study and comparison are carried out under simulations of structural resistance, buckling analysis, and behavior in the MN–skin contact. The application forces are set according to the fracture resistance of the outside layer of the skin. A force of 0.16N for a conical MN is finally obtained as a critical application load to avoid a structural failure in the insertion of the MN in the human skin. Moreover, the use of poly(lactic‐co‐glycolic) acid (PLGA) is also assessed as a second biocompatible alternative due to both its easy handling for manufacture process and the resistance it presents in indentation simulations in which the applied force reaches 0.19N.

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Buckling analysis of polymer microneedle for transdermal drug delivery

Cited by 6 publications

References 15 publications

Micromolding of Amphotericin-B-Loaded Methoxyethylene–Maleic Anhydride Copolymer Microneedles

Micromolding of Amphotericin-B-Loaded Methoxyethylene–Maleic Anhydride Copolymer Microneedles

Post buckling analysis of silicon microneedle

Structural Evaluation by the Finite‐Element Method of Hollow Microneedle Geometries for Drug Delivery

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