Buccal bioadhesive drug delivery — A promising option for orally less efficient drugs

“…The NCT-MAS complex tablets possess mucoadhesive properties, suggesting that MAS still has enough hydroxyl groups to interact with mucus after the complexation with NCT. SA is a polysaccharide that possesses a mucoadhesive property (18,30,31) because it contains numerous hydrogen bondforming groups, i.e., carboxyl and hydroxyl groups. It has been proposed that the interaction between the mucus on mucosal membrane and hydrophilic polymers occurs by physical entanglement and chemical interactions, such as hydrogen bonding (31).…”

Section: Mucoadhesive Properties Of the Tabletsmentioning

confidence: 99%

“…For example, buccal delivery allows drugs to avoid first-pass hepatic metabolism, leading to higher bioavailability and facilitating drug withdrawal (18). NCT is a candidate for buccal delivery due to its low bioavailability after oral administration (1) and its ability to permeate across the buccal mucosa (2,19,20).…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Nicotine–Magnesium Aluminum Silicate Complex-Loaded Sodium Alginate Matrix Tablets for Buccal Delivery

Kanjanabat

2011

AAPS PharmSciTech

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Abstract. Nicotine (NCT) buccal tablets consisting of sodium alginate (SA) and nicotine-magnesium aluminum silicate (NCT-MAS) complexes acting as drug carriers were prepared using the direct compression method. The effects of the preparation pH levels of the NCT-MAS complexes and the complex/SA ratios on NCT release, permeation across mucosa, and mucoadhesive properties of the tablets were investigated. The NCT-MAS complex-loaded SA tablets had good physical properties and zero-order release kinetics of NCT, which indicate a swelling/erosion-controlled release mechanism. Measurement of unidirectional NCT release and permeation across porcine esophageal mucosa using a modified USP dissolution apparatus 2 showed that NCT delivery was controlled by the swollen gel matrix of the tablets. This matrix, which controlled drug diffusion, resulted from the molecular interactions of SA and MAS. Tablets containing the NCT-MAS complexes prepared at pH 9 showed remarkably higher NCT permeation rates than those containing the complexes prepared at acidic and neutral pH levels. Larger amounts of SA in the tablets decreased NCT release and permeation rates. Additionally, the presence of SA could enhance the mucoadhesive properties of the tablets. These findings suggest that SA plays the important role not only in controlling release and permeation of NCT but also for enhancing the mucoadhesive properties of the NCT-MAS complex-loaded SA tablets, and these tablets demonstrate a promising buccal delivery system for NCT.KEY WORDS: buccal tablets; magnesium aluminum silicate; nicotine; release and permeation; sodium alginate.

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“…PAA polymers are available in a wide range of molecular weights. The buccal cavity offers many advantages for drug delivery application and is often associated with high patient compliance, low levels of irritation and significant ease of administration (Jones et al, 2000;Sudhakar and Kuotsu, 2006). The oral cavity is used as a site for local and systemic drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Development and In Vitro Investigation of Mucoadhesive Paste with Methylprednisolone Hydrogen Succinate

Иванова¹

2012

J. App. Pharm. Sci.

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Mucoadhesive pastes with Methylprednisolone hydrogen succinate are characterized with pronounced therapeutic activity in treating Pemfigus vulgaris. Two types of Carbomer as drug release carriers were used: Carbopol ® 971P NF and Carbopol ® 974P NF in concentrations between 27 to 32%. Mucoadhesive pastes were based on paraffin liquid with the use of Magnesium stearate to improve the structural characteristics of the systems. Tests for adhesion, stability and in vitro drug release of developed models of mucoadhesive pastes were carried out. The results obtained show the influence of the type and concentration of polymer used on the adhesion and the rate and degree of drug release. The stability of the developed mucoadhesive pastes was provided by inclusion of 2 wt % magnesium stearate.

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Buccal bioadhesive drug delivery — A promising option for orally less efficient drugs

Cited by 584 publications

References 134 publications

Buccoadhesive Drug Delivery System- A Review

Buccoadhesive Drug Delivery System- A Review

Preparation and Characterization of Nicotine–Magnesium Aluminum Silicate Complex-Loaded Sodium Alginate Matrix Tablets for Buccal Delivery

Development and In Vitro Investigation of Mucoadhesive Paste with Methylprednisolone Hydrogen Succinate

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