Bruising and Bleaching Cosmetics

Ураков, А. Л.; Уракова, Н. А.; Shchemeleva, A.; Fisher, Evgeny

doi:10.5812/jssc.122867

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…It was found that heating solutions of 3% hydrogen peroxide and 2 -10% sodium bicarbonate to the temperature of +37 -+45 • C, alkalizing them to pH 8.4 -8.5 and increasing the content of dissolved carbon dioxide gas or oxygen gas in them due to excess pressure gives them a unique physical and chemical activity. Due to this nonspecific physicochemical activity, WAHPSs have a unique local action on purulent masses (and other biological masses containing the enzyme catalase): pyolytic, bleaching, deodorizing, antihypoxic, oxygenreleasing, disinfecting, detergent and foaming action [50]- [53]. The results of laboratory and experimental studies have shown that irrigation of chronic wounds with WAHPSs and application of prolonged local hyperthermia in wounds shortens the removal of purulent masses from the wound surface and healing of chronic wounds.…”

Section: Discussionmentioning

confidence: 99%

Local Warm Alkaline Hydrogen Peroxide Solutions and Targeted Temperature Management Improve the Treatment of Chronic Wounds

Urakov,

Urakova,

Reshetnikov

et al. 2024

Azb Pharm Pharmaco J

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Introduction: To date, there is no systematic review of the effect of local hypo-, normo- and hyperthermia on the processes of local interaction of antiseptics with dense biological masses covering the surface of chronic wounds. Accelerated and reliable cleansing of the wound surface from purulent masses still remains an unsolved problem of surgery. Methods: 6 inventions were found from beginning to 1986 in databases such as EAPATIS, BYPATENTS, DWPI, DEPATISnet, PATENTSCOPE, Espacenet, RUPTO, USPTO, CIPO, CNIPA, KIPRIS, PatSearch, J-PlatPat, Google Patents and TPO. Due to the small number of inventions, methodological heterogeneity, and differences in the content of their claims, a quantitative meta-analysis could not be performed. Results: The prospects of innovative proposals on the influence of local hypothermia and local hyperthermia on the process of local interaction of antiseptic drug solutions with purulent masses and blood on the surface of chronic wounds have been analyzed. The results of the included studies were presented only qualitatively (descriptively). Conclusion: The first review of inventions presents formulations of invented drugs created by physicochemical repurposing of hydrogen peroxide from antiseptic to pyolytics, mucolytics, hemolytics, expectorants and oxygen-releasing antihypoxants. Warm alkaline hydrogen peroxide solutions (WAHPSs) have been shown to rapidly and reliably dissolve thick purulent masses, blood clots and dried blood spots, turning them into a lush oxygenating foam. Temperature regimes that optimize the sanitizing and washing action of WAHPSs in the treatment of chronic wounds and accelerate hemostasis in parenchymatous bleeding are specified.

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Section: Discussionmentioning

confidence: 99%

Local Warm Alkaline Hydrogen Peroxide Solutions and Targeted Temperature Management Improve the Treatment of Chronic Wounds

Urakov,

Urakova,

Reshetnikov

et al. 2024

Azb Pharm Pharmaco J

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Alkaline hydrogen peroxide solutions: expectorant, pyolytic, mucolytic, haemolytic, oxygen-releasing, and decolorizing effects

Galstyan¹,

Ураков²,

Самородов

et al. 2023

Rev Clin Pharm Drug Ther

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Abstract. It was shown that the effect of local action of hydrogen peroxide solution on such dense biological masses as pus, mucus, sputum and blood clots depends not only on the concentration of the main ingredient, but also on the alkalinity of the solution as well as on the temperature of the interaction media. In particular, an increase in solution temperature from +24 - +26 to +45 - +55 C and its alkalinity from pH 7.0 to pH 8.4 - 8.5 increases the pyolytic, mucolytic, hemolytic, bleaching and oxygen-releasing activity of hydrogen peroxide solutions. The indicated level of hyperthermia is provided by simple physical heating of the solution, and the indicated level of alkalinity is provided by introducing sodium bicarbonate into it. It has been found out that hyperthermia according to the laws of physics reduces viscosity of biological masses, increases their fluidity, permeability to the antiseptic solution, miscibility and solubility in it as well as increases the rate of chemical, physico-chemical and biochemical processes according to Arrhenius law. In particular, increasing the temperature of interacting media accelerates the process of alkaline saponification of proteins and protein-lipid complexes that form the basis of colloidal biological masses. In addition, hyperthermia accelerates and strengthens the process of enzymatic decomposition of hydrogen peroxide into water and oxygen gas, which takes place under the action of the enzyme catalase, which is always present in most biological masses. At the same time, the released molecular oxygen forms gas bubbles, which simulate the process of cold boiling and due to this "explode" biological masses, turning them into a fluffy white foam. The fact is that oxygen in an alkaline environment oxidizes biological pigments, including hemoglobin and its metabolites of different colors, and discolors them.

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Bruising and Bleaching Cosmetics

Cited by 2 publications

References 20 publications

Local Warm Alkaline Hydrogen Peroxide Solutions and Targeted Temperature Management Improve the Treatment of Chronic Wounds

Local Warm Alkaline Hydrogen Peroxide Solutions and Targeted Temperature Management Improve the Treatment of Chronic Wounds

Alkaline hydrogen peroxide solutions: expectorant, pyolytic, mucolytic, haemolytic, oxygen-releasing, and decolorizing effects

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