Alkaline hydrogen peroxide solutions: expectorant, pyolytic, mucolytic, haemolytic, oxygen-releasing, and decolorizing effects

Abstract

Abstract. It was shown that the effect of local action of hydrogen peroxide solution on such dense biological masses as pus, mucus, sputum and blood clots depends not only on the concentration of the main ingredient, but also on the alkalinity of the solution as well as on the temperature of the interaction media. In particular, an increase in solution temperature from +24 - +26 to +45 - +55 C and its alkalinity from pH 7.0 to pH 8.4 - 8.5 increases the pyolytic, mucolytic, hemolytic, bleaching and oxygen-releasing activity of hydrogen peroxide solutions. The indicated level of hyperthermia is provided by simple physical heating of the solution, and the indicated level of alkalinity is provided by introducing sodium bicarbonate into it. It has been found out that hyperthermia according to the laws of physics reduces viscosity of biological masses, increases their fluidity, permeability to the antiseptic solution, miscibility and solubility in it as well as increases the rate of chemical, physico-chemical and biochemical processes according to Arrhenius law. In particular, increasing the temperature of interacting media accelerates the process of alkaline saponification of proteins and protein-lipid complexes that form the basis of colloidal biological masses. In addition, hyperthermia accelerates and strengthens the process of enzymatic decomposition of hydrogen peroxide into water and oxygen gas, which takes place under the action of the enzyme catalase, which is always present in most biological masses. At the same time, the released molecular oxygen forms gas bubbles, which simulate the process of cold boiling and due to this "explode" biological masses, turning them into a fluffy white foam. The fact is that oxygen in an alkaline environment oxidizes biological pigments, including hemoglobin and its metabolites of different colors, and discolors them.

Local Warm Alkaline Hydrogen Peroxide Solutions and Targeted Temperature Management Improve the Treatment of Chronic Wounds

“…At the same time, the released oxygen gas has antiseptic, antihypoxic, deodorizing effect on the wound surface and stimulating effect on aerobic metabolism of granulation tissue [7], [27]. The process of oxygen extraction from hydrogen peroxide is so effective that hydrogen peroxide has been proposed to relieve bronchial asthma attack and acute respiratory syndrome (ARDS) in COVID-19 by inhalation and intrapulmonary injection of WAHPs.…”

“…This study aimed to find evidence for the feasibility of LWT in the treatment of chronic wounds. From the review of inventions and scientific articles, it is evident that one of the important factors in the long-term healing of chronic wounds is the local temperature of the wound bed, purulent masses covering the wound surface, and solutions of standard washing and antiseptic drugs [7], [27], [40].…”

“…To increase the efficiency of removing thick purulent masses with WAHPSs from various surfaces, including the wound surface, it has been proposed to saturate WAHPSs solutions with pressurized gases [20], [21], [31]. Studies have shown that due to moderate hyperthermia, alkaline activity and hypergassing, WAHPSs acquire a unique physicochemical activity that gives them leadership in dissolving thick purulent masses [27]. Therefore, in 2023, it was first proposed to complement the treatment of chronic wounds with pyolytics and warm wound dressings.…”