Brucellosis presenting as septic shock

Haran, Mehandi; Agarwal, Amit; Kupfer, Yizhak; Seneviratne, Chanaka; Chawla, Kabu; Tessler, Sidney

doi:10.1136/bcr.12.2010.3586

Cited by 14 publications

(10 citation statements)

References 7 publications

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“…It can also manifest again after a long period of quiescence. A man in the United States had a recurrence of brucellosis, which presented as septic shock 50 years after his first infection, 5 whereas in a separate case, a former abattoir worker was diagnosed with brucellosis 18 years after his known exposure to the risk factors. 6 Brucellosis can also manifest as a localized disease, affecting the central and peripheral nervous system, and the gastrointestinal, hepatobiliary, genitourinary, musculoskeletal, cardiovascular, and integumentary systems.…”

Section: Introductionmentioning

confidence: 99%

Outbreak of Human Brucellosis from Consumption of Raw Goats' Milk in Penang, Malaysia

Leong¹,

Chow²,

Wong³

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. We report the largest outbreak of brucellosis in Penang, Malaysia. Brucellosis is not endemic in this region. The index case was a 45-year-old goat farm owner presented with 3 weeks of fever, headache, severe lethargy, poor appetite, and excessive sweating. He claimed to have consumed unpasteurized goat's milk that he had also sold to the public. Tests were negative for tropical diseases (i.e., dengue fever, malaria, leptospirosis and scrub typhus) and blood culture showed no growth. Based on epidemiological clues, Brucella serology was ordered and returned positive. Over a period of 1 year, 79 patients who had consumed milk bought from the same farm were diagnosed with brucellosis. Two of these patients were workers on the farm. Four laboratory staff had also contracted the disease presumably through handling of the blood samples. The mean duration from onset of symptoms to diagnosis was 53 days with a maximum duration of 210 days. A combination treatment of rifampin and doxycycline for 6 weeks was the first line of treatment in 90.5% of patients. One-third of the patients had sequelae after recovering and 21% had a relapse. We highlight the importance of Brucellosis as a differential diagnosis when a patient has unexplained chronic fever.

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Section: Introductionmentioning

confidence: 99%

Outbreak of Human Brucellosis from Consumption of Raw Goats' Milk in Penang, Malaysia

Leong¹,

Chow²,

Wong³

et al. 2015

The American Society of Tropical Medicine and Hygiene

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“…Despite a good health care system in Iran, brucellosis is still an important endemic disease. Iran ranks fourth in the world of the incidence of brucellosis (5)(6)(7). According to the National Guidelines, epidemiological and clinical data of patients in Iran are recorded online in the health monitoring system.…”

Section: Introductionmentioning

confidence: 99%

Predicting the Incidence of Brucellosis in Western Iran using Markov switching model

Sadeghifar

Cheraghi

Hosseinkhani

2020

Preprint

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ObjectiveBrucellosis is a zoonosis almost chronic disease. Brucellosis bacteria can remain in the environment for a long time. Thus, climate irregularities could pave the way for the survival of the bacterium Brucellosis. Brucellosis is more common in men 25 to 29 years of age, in the western provinces, and in the spring months. The aim of this study is to investigate the effect of climatic factors as well as predicting the incidence of Brucellosis in Qazvin province using the Markov switching model (MSM). This study is a secondary study of data collected from 2010 to 2019 in Qazvin province. The data include Brucellosis cases and climatic parameters. Two state MSM with time lags of 0, 1 and 2 was fitted to the data. The Bayesian information criterion (BIC) was used to evaluate the models.ResultsAccording to the BIC, the two-state MSM with a one-month lag is a suitable model. The month, the average-wind-speed, the minimum-temperature have a positive effect on the number of brucellosis, the age and rainfall have a negative effect. The results show that the probability of an outbreak for the third month of 2019 is 0.30%.

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“…Complicated infections are more likely to occur in immunocompromised hosts and require prompt diagnosis and early institution of appropriate therapy that includes surgical drainage, antimicrobial chemotherapy, artificial ventilation and transfusion of blood products [79][80][81][82].…”

Section: Other Serious Complications Of Brucella Infectionmentioning

confidence: 99%

“…Rare but potentially life-threatening complications of brucellosis include: (1) disseminated infection with nodules and abscesses in the liver, spleen, gall bladder, lung, pleura and spine, (2) pancytopenia combined with endocarditis or meningitis, and (3) Brucella bacteremia that may cause septic shock [79][80][81][82]. Complicated infections are more likely to occur in immunocompromised hosts and require prompt diagnosis and early institution of appropriate therapy that includes surgical drainage, antimicrobial chemotherapy, artificial ventilation and transfusion of blood products [79][80][81][82].…”

Section: Other Serious Complications Of Brucella Infectionmentioning

confidence: 99%