Brucellosis and rheumatic syndromes in Saudi Arabia.

Norton, Walter L.

doi:10.1136/ard.43.6.810

Cited by 41 publications

(13 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[9][10][11][12][13][14] This surge in incidence of brucellosis in animals and humans during this period has been strongly linked to the uncontrolled importation of potentially infected animals with brucellosis, widespread animal husbandry, and the prevailing habit of ingesting raw milk or its products among the population of nomadic background.…”

mentioning

confidence: 99%

Brucellosis in Saudi Arabia: Past, Present and Future

Al‐Eissa

1999

Ann Saudi Med

View full text Add to dashboard Cite

mentioning

confidence: 99%

Brucellosis in Saudi Arabia: Past, Present and Future

Al‐Eissa

1999

Ann Saudi Med

View full text Add to dashboard Cite

“…Several studies have demonstrated that the brucellosis caused Brucella spp involved a diversity of clinical signs and symptoms including arthritis (31)(32)(33)(34)(35). Furthermore, some studies showed the relationship of brucellosis and rheumatic symptoms (32).…”

Section: Discussionmentioning

confidence: 99%

Comparative Gene Expression Analysis within Mouse Macrophage for Identifying Critical Pathways in Macrophage and Brucella suis Interaction

Wang

Zhao

et al. 2017

Jundishapur J Microbiol

View full text Add to dashboard Cite

Background: Brucella spp. are Gram-negative bacteria that cause a zoonotic disease called brucellosis in humans as well as many animals. Brucella suis (B.suis) is one of the greatest threats to the human health and food safety. Studying macrophage and B. suis interaction is critical for understanding the chronic infection mechanism. However, the interaction mechanisms, especially for molecular events triggered by B. suis infected macrophage, such as biological pathways, are still obscure. Objectives: We will use gene set enrichment analysis (GSEA) to microarray in an attempt to find critical pathways in the interaction of macrophage and B. suis. Methods: We applied a standardized microarray preprocessing and GSEA to 2 independent macrophage and B. suis interaction studies including smooth virulent B. suis strain 1330 (S1330) data sets and rough attenuated B. suis strain VTRS1 (VTRS1) data sets. Integrative analysis was used to find critical pathways for 2 independent macrophage and B. suis interaction data sets. Results:The results demonstrated that for S1330 data sets, 8 and 13 common up-and down-regulated pathways were found in 4 interaction stages including 4h, 8h, 24h, and 48h post macrophage infected S1330 B. suis, and for VTRS1 data sets, we found 30 and 19 common up-and down-regulated pathways. Comparing the results of S1330 and VTRS1 data sets, 6 and 8 common up-and downregulated pathways were identified. Conclusions:The study of macrophage and B. suis interaction through pathway analysis highlighted genes weakly connected to the phenotype, and discovered common critical pathways in the process of macrophages and different phenotypes of B. suis interaction. The identified pathways will shed light on the understanding of the functional events within macrophage post infected B. suis.

show abstract

“…The other clinical features of brucellosis include: night sweats, chills and rigors, anorexia, malaise, weakness, weight loss, headache, arthralgia, myalgia, low backache, dizziness, depressed mood, dyspepsia, nausea, vomiting, abdominal pain, cough, dyspnea, epistaxis and hemoptesis, burning micturition, testicular pain, swollen and tender joints, tenderness over the lumbosacral spine, splenomegaly, hepatomegaly, external lymphadenopathy, jaundice, mouth ulcerations, scrotal swelling in addition to various cutaneous eruptions [1-5,9-11,22,57,-61]. In a study performed in Saudi Arabia that included 73 episodes of brucellosis in 55 patients, 44% of the patients had rheumatic manifestations such as arthritis and spondylitis [62]. Brucellosis can have several presentations and the disease has several stages: acute, sub-acute, chronic, relapsing, active and non-active.…”

Section: Clinical Manifestations Of Brucellosismentioning

confidence: 99%

“…Relapses occur in up to 29% of patients with brucellosis and they usually occur within 12 months of discontinuation of the antimicrobial therapy [1,3,5,58,62]. The risk factors for relapse include: male sex, old age, lymphopenia, deficient immunologic response such as in patients having human immunodeficiency virus (HIV) infection, presence of an aggressive disease or a chronic infection, positive blood cultures during initial infection, and an inadequately treated infection [1,3,5,[83][84][85][86].…”

Section: Relapse Of Brucellosismentioning

confidence: 99%