Brucellosis

Pappas, Georgios; Akritidis, Nikolaos; Bosilkovski, Mile; Tsianos, Epameinondas V.

doi:10.1056/nejmra050570

Cited by 1,189 publications

(1,282 citation statements)

References 93 publications

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“…Brucella spp. usually infect people through contaminated meat and direct contact with the infected animals [5]. Generally, in patients with risk factors such as consumption of contaminated foods and occupational contact, Brucella spp.…”

Section: Introductionmentioning

confidence: 99%

Clinical features and serum profile of inflammatory biomarkers in patients with brucellosis

Liu

Zhao

2017

J Infect Dev Ctries

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Introduction: Brucellosis is a zoonosis caused by Brucella, a highly infectious Gram-negative coccobacillus that has been isolated from a variety of mammals. Brucella melitensis is considered the most common cause of human brucellosis. The aim of this retrospective study was to evaluate the diagnostic value of serum parameters that relate to Brucella melitensis infection. Methodology: This investigation retrospectively analyzed the clinical laboratory tests and symptoms of brucellosis, which was confirmed by microbiological and serological methods. A total of 36 patients (31 males, 5 females; mean age 49.17 ± 13.56 years) admitted with brucellosis were included in the study over a three-year period between 2012 and 2015 in Peking University People's Hospital (PKUPH). Results: A statistically significant increase was observed in C-reactive protein and erythrocyte sedimentation rate in patients with low titers of serum antibody when compared with those with high titers. No difference was observed between the two groups with respect to the other serum parameters such as procalcitonin or white blood cell count. Two blood culture systems also yielded different results. Conclusions: In this study, we demonstrated that culture can be improved by using multiple blood culture systems to isolate Brucella melitensis. We also found the different role of inflammatory markers play during the process of brucellosis. The present study may be a helpful reference in the diagnosis of brucellosis.

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Section: Introductionmentioning

confidence: 99%

Clinical features and serum profile of inflammatory biomarkers in patients with brucellosis

Liu

Zhao

2017

J Infect Dev Ctries

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“…Preparation of Na-(tert-butoxycarbonyl)-Nt-methoxytrityl-L-histidine hydrazide (2). To a solution of methyl N a -(tert-butoxycarbonyl-N t -methoxytritryl-L-histidinate 1 (1eq.)…”

Section: Chemistrymentioning

confidence: 99%

Brucella suishistidinol dehydrogenase: Synthesis and inhibition studies of substituted N-L-histidinylphenylsulfonyl hydrazide

Abdo

Joseph

Boigegrain

et al. 2008

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…Brucellosis represents a zoonosis typically transmitted directly or indirectly by exposure to animals (2). Human brucellosis is caused by the Brucella species.…”

Section: Introductionmentioning

confidence: 99%

Brucellosis Risk Factors in the Southwestern Province of Khuzestan, Iran

Alavi¹,

Mugahi²,

Nashibi³

et al. 2014

Int J Enteric Pathog

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Background: Brucellosis is an endemic infectious disease in Iran. Prevention strategies are based upon identification of risk factors for brucellosis. Objectives: The purpose of this study was to determine the principal risk factors for brucellosis in Khuzestan Province, Southwestern Iran. Patients and Methods: In this retrospective study, the medical records of 162 admitted patients, 81 brucellosis cases and 81 controls with other unrelated conditions, were reviewed. The study was undertaken in the Razi Hospital, Teheran, I.R. Iran, a university hospital where infected patients throughout Khuzestan are refereed. The diagnostic criteria of the disease were the Wright test and 2-Mercaptoethanol (2ME) agglutinin assay with titers greater than 1:160 and 1:80, respectively, and clinical symptoms compatible with brucellosis. Statistical analyses were performed with the SPSS 16.0 software. Univariate analysis was performed by calculating the odds ratio (OR) and the 95% confidence interval (CI) to compare cases and controls for each variable. Results: Of a total of 81 patients with brucellosis, 38 (46.8%) had had direct contact with animals, 47 (58%) had consumed high risk foods, and 48 (59.2%) were from rural areas. Analysis showed that brucellosis had a significant association with untreated milk consumption (OR 5.57, 95% CI = 1.77-17.08, P = 0.002), slaughtered meat (OR: 8.77, 95% CI = 1.07-71.81, P = 0.03), direct contact with animals and individuals who had a nomadic lifestyle (OR: 3.57, 95% CI = 1.34-9.54, P = 0.01). Conclusions: In the studied region, the main risk factors for brucellosis are: consumption of untreated milk/dairy products, slaughtered meat and direct contact with animals. Therefore, improved veterinary services and public health education are a requisite to control the disease.

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Brucellosis

Cited by 1,189 publications

References 93 publications

Clinical features and serum profile of inflammatory biomarkers in patients with brucellosis

Clinical features and serum profile of inflammatory biomarkers in patients with brucellosis

Brucella suishistidinol dehydrogenase: Synthesis and inhibition studies of substituted N-L-histidinylphenylsulfonyl hydrazide

Brucellosis Risk Factors in the Southwestern Province of Khuzestan, Iran

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