Clinical features and serum profile of inflammatory biomarkers in patients with brucellosis

Liu, Jingbo; Zhao, Xiang‐Yu

doi:10.3855/jidc.8872

Cited by 10 publications

(10 citation statements)

References 14 publications

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“…Early assessment of the risk of brucellosis relies on information derived from clinical examinations and laboratory findings. 15 Of the 132 patients studied here, 8.3% had anemia, 6.1% had thrombocytopenia and 70.0% had normal blood cell counts. A slight elevation of liver enzyme levels could be detected in approximately 20% of all patients with brucellosis.…”

Section: Discussionmentioning

confidence: 70%

Epidemiological and clinical characteristics of bacteremic brucellosis

et al. 2020

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Objective To retrospectively investigate the epidemiological features, clinical manifestations and laboratory characteristics of bacteremic brucellosis. Methods Brucellosis patients admitted to our clinic from January 2015 to December 2017 were included in the study. Patient electronic medical records were reviewed for epidemiological features, clinical manifestations, and laboratory findings. Results A total of 132 brucellosis patients were analyzed (64 cases with bacteremic brucellosis and 68 cases with nonbacteremic brucellosis). The median duration from exposure to onset of symptoms was 6.9 weeks (range: 1 day to 32 weeks) and 21.9 weeks (range: 1–76 weeks) in patients with bacteremic and nonbacteremic brucellosis, respectively. More bacteremic than nonbacteremic patients presented with fever and chills. Arthritis was observed in 34 (25.8%) patients, and was more commonly observed in nonbacteremic patients. Using C-reactive protein (CRP) and procalcitonin (PCT) as serological markers, the areas under the receiving operating characteristic curves were 0.64 [95% confidence interval (CI): 0.54–0.73] and 0.61 (95% CI: 0.51–0.70), respectively, for distinguishing bacteremic from non-bacteremic brucellosis. Conclusion Fever and chills were frequently observed in bacteremic brucellosis patients, whereas arthritis was more common in nonbacteremic brucellosis patients. Serum CRP and PCT can be used as potential serological markers for diagnosing bacteremic brucellosis.

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Section: Discussionmentioning

confidence: 70%

Epidemiological and clinical characteristics of bacteremic brucellosis

et al. 2020

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“…However, because none of the studies assessed PCT and endotoxemia tests in the same population, direct comparison between PCT and endotoxemia was not feasible. Increased leukocyte count is also demonstrated in some researches as a feature of GNBSI and showed potential in differentiation between GNBSI and other types of bloodstream infection, but few studies analyzed the corresponding diagnostic indices, such as specificity, sensitivity, and AUC [59][60][61][62][63][64][65]. Additionally, promising results of TNF-α and IL-8 tests were reported in predicting GNBSI in abdominal sepsis patients, with AUCs being 0.912 and 0.999, sensitivities being 90.2% and 97.6%, and specificities being 87.5% and 100%, respectively [66].…”

Section: Pct In Comparison Withmentioning

confidence: 99%

Diagnostic Accuracy of Procalcitonin Compared to C-Reactive Protein and Interleukin 6 in Recognizing Gram-Negative Bloodstream Infection: A Meta-Analytic Study

Lai

Wang

et al. 2020

Disease Markers

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Objective. Gram-negative bloodstream infections (GNBSIs), especially those caused by antibiotic-resistant species, have become a public health challenge. Procalcitonin (PCT) showed promising potential in early diagnosis of GNBSI; however, little was known about its performance under different clinical settings. We here systematically assessed the diagnostic accuracy of PCT in recognizing GNBSI and made direct comparisons with C-reactive protein (CRP) and interleukin 6 (IL-6). Methods. PubMed, Embase, ISI Web of Knowledge, and Scopus were searched from inception to March 15th, 2019. Area under the summary receiver operating characteristic curve (AUC), pooled sensitivity, specificity, and diagnostic odds ratio (DOR) were calculated. Hierarchical summary receiver operating characteristic (HSROC) model was used for the investigation of heterogeneity and for comparisons between markers. Results. 25 studies incorporating 50933 suspected BSI episodes were included. Pooled sensitivity and specificity for PCT were 0.71 and 0.76, respectively. The overall AUC was 0.80. The lowest AUCs were found in patients with febrile neutropenia (0.69) and hematological malignancy (0.69). The highest AUC was found in groups using electrochemiluminescence immunoassay (0.87). In direct comparisons, PCT showed better overall performance than CRP with the AUC being 0.85 (95% CI 0.81–0.87) for PCT and 0.78 (95% CI 0.74–0.81) for CRP, but the relative DORs varied with thresholds between PCT and CRP (p<0.001). No significant difference was found either in threshold (p=0.654) or in accuracy (p=0.480) between PCT and IL-6 in diagnosing GNBSI. Conclusions. PCT was helpful in recognizing GNBSI, but the test results should be interpreted carefully with knowledge of patients’ medical condition and should not serve as the only criterion for GNBSI. Further prospective studies are warranted for comparisons between different clinical settings.

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“…Because of these characteristics, it is easy to cause clinical missed diagnosis and misdiagnosis, delay the disease, and even cause complications such as arthritis, myocarditis and liver and spleen involvement [ 13 ]. Many studies have shown that CRP and PCT are sensitive indicators for the diagnosis of Brucellosis [ 17 , 18 ]. The cure rate of acute brucellosis infection is 90-95%, while the chronic infection caused by brucellosis has not been cured, so early diagnosis and treatment of brucellosis are very important.…”

Section: Discussionmentioning

confidence: 99%

Rickettsia burneti and Brucella melitensis co-infection: a case report and literature review

Song

et al. 2021

BMC Microbiol

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Rickettsia is the pathogen of Q fever, Brucella ovis is the pathogen of brucellosis, and both of them are Gram-negative bacteria which are parasitic in cells. The mixed infection of rickettsia and Brucella ovis is rarely reported in clinic. Early diagnosis and treatment are of great significance to the treatment and prognosis of brucellosis and Q fever. Here, we report a case of co-infection Rickettsia burneti and Brucella melitensis. The patient is a 49-year-old sheepherder, who was hospitalized with left forearm trauma. Three days after admission, the patient developed fever of 39.0°C, accompanied by sweating, fatigue, poor appetite and headache. Indirect immunofluorescence (IFA) was used to detect Rickettsia burneti IgM. After 72 hours of blood culture incubation, bacterial growth was detected in aerobic bottles, Gram-negative bacilli were found in culture medium smear, the colony was identified as Brucella melitensis by mass spectrometry. Patients were treated with doxycycline (100 mg bid, po) and rifampicin (600 mg qd, po) for 4 weeks. After treatment, the symptoms disappeared quickly, and there was no sign of recurrence or chronic infection. Q fever and Brucella may exist in high-risk practitioners, so we should routinely detect these two pathogens to prevent missed diagnosis.

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Clinical features and serum profile of inflammatory biomarkers in patients with brucellosis

Cited by 10 publications

References 14 publications

Epidemiological and clinical characteristics of bacteremic brucellosis

Epidemiological and clinical characteristics of bacteremic brucellosis

Diagnostic Accuracy of Procalcitonin Compared to C-Reactive Protein and Interleukin 6 in Recognizing Gram-Negative Bloodstream Infection: A Meta-Analytic Study

Rickettsia burneti and Brucella melitensis co-infection: a case report and literature review

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