Brown Tumor as a Result of Hyperparathyroidism in an End-Stage Renal Disease Patient

Jakubowski, J; Velez, Inés; McClure, Shawn A.

doi:10.1155/2011/415476

Cited by 18 publications

(16 citation statements)

References 7 publications

(9 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It may appear in any bone, but is often found in the bones of the face and jaw, especially in cases of longstanding disease 1 . In this case, the lesion was located in the mandibular symphysis region, a fact consistent with the literature 1,7,11,12 .…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Brown tumor as a result of secondary hyperparathyroidism in chronic renal disease

Mascarenhas¹,

Marchionni²,

Rebouças³

et al. 2016

J Oral Diag

View full text Add to dashboard Cite

Introduction: Brown tumor is a focal lesion of giant cells that develops in association with hyperparathyroidism. Objective: To report a case of brown tumor that occurred in the mandibular symphysis region, associated with secondary hyperparathyroidism. Case report: A 45-year-old male patient with chronic renal failure exhibited increased volume with comorbid local paresthesia in the mandibular symphysis region. Radiographs showed a unilocular radiolucent area with partially defined edges in the anterior mandible region. The histopathological findings revealed connective tissue, rich in oval, notched cells and giant cells with hemosiderin pigments. Laboratory tests showed increased serum levels of parathyroid hormone. An attempt to control the hormone levels with medication while the patient awaited a kidney transplant was unsuccessful. Therefore, as a transplant was not imminent and injury continued to develop, the lesion was surgically excised. Three years later, the lesions recurred in the paranasal region. Following partial removal of the lesions, the patient is now under follow-up care. Conclusion: Correct diagnosis and effective treatment of brown tumor requires correlation of biochemical data with the patient's clinical, imaging, and histological profile.

show abstract

Section: Discussionsupporting

confidence: 91%

“…Histological characteristics of brown tumor demonstrate highly vascular connective tissue with diffusely distributed multinucleated giant cells, and areas of hemorrhage and hemosiderin deposits 6 . Skeletal demineralization, resulting from elevated plasma calcium, leads to multinucleated giant cells or osteoclasts replacing bone 7,3 .…”

Section: Introductionmentioning

confidence: 99%

Brown tumor as a result of secondary hyperparathyroidism in chronic renal disease

Mascarenhas¹,

Marchionni²,

Rebouças³

et al. 2016

J Oral Diag

View full text Add to dashboard Cite

show abstract

“…Mandibular hypercorticalization, as revealed by radiologic investigation, is not a typical manifestation of hyperparathyroidism. 15 Palatal swelling Yes Cystic palatal mass Brown tumor Primary-adenoma Mandibular swelling Jafari-Pozve et al 4 Bony pain Yes Multiple radiolucencies Brown tumor Secondary-renal failure Swelling of the cheeks Vardhan et al 16 Maxillary swelling Yes Loss of lamina dura Giant cell lesion Primary-adenoma Pain Ground-glass trabecular pattern Maxillary radiolucency Jakubowski et al 17 Mandibular edema Yes Unilocular radiolucency Brown tumor Secondary-renal failure Pain Obliterated mandibular canal Intra-oral nightly bleeding Displaced molars Devresse et al 18 Painfull swelling of the Yes Osteolytic mandibular lesion Ossifying fibroma Secondary-renal failure Mouth floor Magalhães et al 19 Mandibular molar Yes Ground glass trabecular pattern Brown tumors Tertiary-renal transplant Pain Osteolytic lesions Nair et al 20 Mandibular swelling Yes Lytic lesion Brown tumor Secondary-vitamin D deficit Outer cortex sclerosis Verma et al 21 Pain Yes Loss of lamina dura Brown tumor Secondary-renal failure Facial swelling Ground-glass trabecular pattern Multilocular radiolucenties Bicortical expansion hyperPTH, hyperparathyroidism.…”

Section: Resultsmentioning

confidence: 99%

“…In contrast to our patient, bony hypercorticalization wasn't reported in any of these cases. 4,[13][14][15][16][17][18][19][20][21] Because hypercorticalization is not a typical oral manifestation of hyperparathyroidism, extensive technical investigations to rule out other etiologies were performed. The most common reported radiologic feature of hyperparathyroidism is a loss of the lamina dura in 7%-46% of cases.…”

Section: Discussionmentioning

confidence: 99%

Secondary hyperparathyroidism causing increased jaw bone density and mandibular pain: a case report

Aerden

Grisar

Nys

et al. 2018

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

View full text Add to dashboard Cite

We present the case of a 32-year-old male patient complaining of recurrent mandibular pain for 3.5 years. Panoramic radiography indicated increased cortical density of the mandibular lower border. Scintigraphy and single-photon emission computed tomography revealed metabolic hyperactivity in that region without pathologic lymph nodes. A bone biopsy specimen of the mandibular lower border did not have inflammation or cytologic atypia. Endocrinologic investigation confirmed secondary hyperparathyroidism as a result of hypovitaminosis D. Several weeks after starting therapy with oral vitamin D supplements, the symptoms completely disappeared. Increased cortical density is a rare manifestation of secondary hyperparathyroidism, which normally causes the lamina dura to vanish and produces a ground-glass appearance as a result of blurring of the trabecular bone pattern. Because focal hyperostosis can have multiple benign or malignant causes, radiologic examination of the jaw bones is indispensable for evaluating orofacial pain. Increased cortical density may be caused by metabolic diseases, requiring further investigations, including biopsy and blood analysis.

show abstract

“…Analysis of this data is provided in Table 1 . Only 5 of those cases occurred in the United States [ 8 – 12 ]. Of those, four had primary HPT, and one had secondary disease, as our patient did.…”

Section: Discussionmentioning

confidence: 99%

Mandibular Brown Tumor of Secondary Hyperparathyroidism Requiring Extensive Resection: A Forgotten Entity in the Developed World?

Qaisi

Loeb

Montague

et al. 2015

Case Reports in Medicine

View full text Add to dashboard Cite

Brown tumor of hyperparathyroidism (BTHPT) is rare in the United States and not frequently seen in clinical practice. This is likely because early diagnosis and prompt treatment of this disease process prevent the progression and development of BTHPT. Conversely, BTHPT is more common in underdeveloped countries where fewer patients have access to health care and hyperparathyroidism (HPT) goes untreated. It has been reported that the incidence of BTHPT in underdeveloped countries can be as high as 58 to 69 percent in patients with primary HPT. We present a case report of a patient in the United States with a large mandibular BTHPT requiring an extensive resection in the setting of secondary HPT. Despite being rare in this country, it is important for nephrologists, primary care physicians, and oral health care providers to be able to recognize this entity, so that intervention may be rendered early.

show abstract

Brown Tumor as a Result of Hyperparathyroidism in an End-Stage Renal Disease Patient

Cited by 18 publications

References 7 publications

Brown tumor as a result of secondary hyperparathyroidism in chronic renal disease

Brown tumor as a result of secondary hyperparathyroidism in chronic renal disease

Secondary hyperparathyroidism causing increased jaw bone density and mandibular pain: a case report

Mandibular Brown Tumor of Secondary Hyperparathyroidism Requiring Extensive Resection: A Forgotten Entity in the Developed World?

Contact Info

Product

Resources

About