Brown-McLean Syndrome in a Pediatric Patient

Abstract

The purpose of this manuscript is to report the case of a 12-year-old patient who presented for routine ophthalmic examination after congenital cataract surgery performed at 2 months of age.The patient was diagnosed with bilateral Brown-McLean syndrome by slit lamp examination. No treatment was required because the patient was asymptomatic and had a clear central cornea. This is the first described case of Brown-McLean syndrome in a pediatric patient, representing the importance of clinical examination in the pediatric age group after cataract surgery because of the risk for patients of developing peripheral edema.

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“…However, it is reasonable to assume a genetic predisposition, as it was reported in 3 members of an extended family who presented with bilateral peripheral corneal edema. [ 1 3 5 6 ] There are other predisposing factors that have been reported as in our case, such as high myopia, dislocation of the lens, and intermittent angle-closure glaucoma. Other possible predisposing factors include chronic uveitis and iridodonesis in aphakic patients that may cause intermittent abrasion of the corneal endothelium leading to peripheral corneal edema.…”

“…In addition, it has been documented in patients with no previous ocular surgery, including in patients with spontaneous lens resorption with iridodonesis, lens subluxation or luxation, the phakic eye with intermittent angle-closure, keratoconus, and myotonic dystrophy. [ 1 2 3 4 5 ]…”

“…Lens zonules normally have a high cysteine content, and its deficiency may affect normal zonular development, thereby predisposing to myopia and lens dislocation. [ 1 2 3 ]…”