Brown Macroalgae Sargassum cristaefolium Extract Inhibits Melanin Production and Cellular Oxygen Stress in B16F10 Melanoma Cells

Prasedya, Eka Sunarwidhi; Padmi, Hasriaton; Ilhami, Bq Tri Khairina; Martyasari, Ni Wayan Riyani; Sunarwidhi, Anggit Listyacahyani; Widyastuti, Sri; Khairinisa, Miski Aghnia; Cokrowati, Nunik; Simangunsong, Erika Ernawati; Frediansyah, Andri

doi:10.3390/molecules27238585

Cited by 4 publications

(1 citation statement)

References 68 publications

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“…Spesies ini termasuk alga coklat memiliki kandungan anti oksidan yang lebih banyak dibanding dengan alga hijau dan alga merah (Nazarudin et al, 2020). Sargassum cristaefolium memiliki kemampuan menghambat produksi melanin dan stress oksigen selular pada sel melanoma (Prasedya et al, 2022).…”

Section: Sargassum Aquifoliumunclassified

The Potential and Development of Seaweed Cultivation in Lombok: A Review

Cokrowati

Risjani

Andayani

et al. 2023

JBT

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The potential area of Lombok seaweed cultivation is 5490 Ha. The area utilized is 2039.63 Ha. The purpose of this paper is to review the diversity, cultivation activities, production and potential of seaweed to be developed, specifically focusing on aspects of cultivation and production on the island of Lombok, Indonesia. Macroalgae that have been cultivated on Lombok are Kappaphycus alvarezii morphotype brown and green and Gracilaria verucosa. The decline and the amount of uncertainty in production were caused by several problems in seaweed cultivation, weather changes, limited capital for production and decreased quality of seaweed seeds. The species that have the potential to be developed are Sargassum aquifolium, Caulerpa sp., Ulva sp., Eucheuma spinosum, and Gelidium sp. Development Locations are located throughout the waters in the shape of a bay and are by the stipulated water utilization spatial plan. Developing seaweed aqua tourism and institutional arrangements related to seaweed production is necessary.

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Section: Sargassum Aquifoliumunclassified

The Potential and Development of Seaweed Cultivation in Lombok: A Review

Cokrowati

Risjani

Andayani

et al. 2023

JBT

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Tyrosinase inhibitory activity of Sargassum fusiforme and characterisation of bioactive compounds

Javed

Alam

Naznin

et al. 2023

Phytochemical Analysis

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IntroductionSargassum fusiforme (Harvey) Setchell, also known as Tot (in Korean) and Hijiki (in Japanese), is widely consumed in Korea, Japan, and China due to its health promoting properties. However, the bioactive component behind the biological activity is still unknown.ObjectivesWe aimed to optimise the extraction conditions for achieving maximum tyrosinase inhibition activity by using two sophisticated statistical tools, that is, response surface methodology (RSM) and artificial neural network (ANN). Moreover, high‐resolution mass spectrometry (HRMS) was used to tentatively identify the components, which are then further studied for molecular docking study using 2Y9X protein.MethodologyRSM central composite design was used to conduct extraction using microwave equipment, which was then compared to ANN. Electrospray ionisation tandem mass spectrometry (ESI‐MS/MS) was used to tentatively identify bioactive components, which were then docked to the 2Y9X protein using AutoDock Vina and MolDock software.ResultsMaximum tyrosinase inhibition activity of 79.530% was achieved under optimised conditions of time: 3.27 min, temperature: 128.885°C, ethanol concentration: 42.13%, and microwave intensity: 577.84 W. Furthermore, 48 bioactive compounds were tentatively identified in optimised Sargassum fusiforme (OSF) extract, and among them, seven phenolics, five flavonoids, five lignans, six terpenes, and five sulfolipids and phospholipids were putatively reported for the first time in Sargassum fusiforme. Among 48 bioactive components, trifuhalol‐A, diphlorethohydroxycarmalol, glycyrrhizin, and arctigenin exhibited higher binding energies for 2Y9X.ConclusionTaken together, these findings suggest that OSF extract can be used as an effective skin‐whitening source on a commercial level and could be used in topical formulations by replacing conventional drugs.

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