Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus

Cheng, Lijun; Wang, Jingkang; Dai, Hongyu; Duan, Yuhui; An, Yongcheng; Shi, Lu; Lv, Yinglan; Li, Huimin; Wang, Chen; Ma, Quantao; Li, Yaqi; Li, Pengfei; Du, Haifeng; Zhao, Baosheng

doi:10.1080/21623945.2020.1870060

Cited by 221 publications

(164 citation statements)

References 156 publications

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“…Adipose tissue response to cold demonstrates the elasticity and the highly dynamic state this tissue possesses [11,14,19]. This is clearly shown in the WAT tissue response to extended cold treatment where it can be differentiated into what is called beige or brite adipocytes [11,14,19]. Like BAT, beige cells exhibit a high level of UCP1 and many mitochondria with high thermogenetic capacity.…”

Section: Discussionmentioning

confidence: 97%

“…This role has been mostly inferred based on its increased expression during adipocyte differentiation [10]. One of the most important organs involved in controlling lipid metabolism are the white and brown adipose tissues [11][12][13]. In addition to their role in energy storage, adipocytes release various signals that regulate whole body metabolism [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, brown adipocytes are a powerhouse that consumes a large amount of energy which can enhance energy expenditure and alleviates insulin resistance by creating a negative energy balance [11][12][13]. Brown adipose tissue facilitates the mitochondrial heat production through a non-shivering mechanism that uncouples ATP production from substrate metabolism [11,14]. Moreover, shifting white adipocytes into brown or beige adipocytes is a eld of high value as it constitutes a mechanism to increase energy expenditure and enhance metabolic function.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, shifting white adipocytes into brown or beige adipocytes is a eld of high value as it constitutes a mechanism to increase energy expenditure and enhance metabolic function. Adipocyte browning is a natural process that is induced by cold treatment or by exercise [11,14]. LPL is one enzyme that has been shown to be activated by short cold exposure [15].…”

Section: Introductionmentioning

confidence: 99%

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Increased expression level of ANGPTL8 in White Adipose tissue under Chronic Cold Treatment

Arefanian

Al-Khairi

Khalaf

et al. 2021

Preprint

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Background It is well known that Angiopoietin like protein (ANGPTL) mainly 3, 4 and 8 play a major role in maintaining energy homeostasis by regulating lipoprotein lipase (LPL) activity, which is a key regulator of triglyceride (TG) metabolism. Our aim is to evaluate the level of ANGPTL3, 4 and 8 in mice maintained under cold conditions in the liver, brown adipose tissue (BAT), and white adipose tissue (WAT). Methods C57BL/6J mice were exposed to cold temperature at 4˚C over a period of ten days with food given ad libitum. Animal tissues were harvested at days 0, 1, 3, 5, and 10 (cold treatment groups, n = 10 in each group, control, n = 5). Liver, subcutaneous adipose tissue (SAT), and BAT were used to investigate the expression level of different genes. ANGPTL3, 4 and 8 genes expression were measured in liver. ANGPTL4, 8 and UCP1 were measured in SAT and BAT. Results ANGPTL 3 and 8 gene expression levels were significantly reduced in mice liver tissues after cold treatment (P-value < 0.05). However, the gene expression level of ANGPTL4 was not significantly changed. In BAT, ANGPTL8 expression was not changed after cold treatment while ANGPTL4 was significantly reduced (P-value < 0.05). ANGPTL4 level was also significantly reduced in SAT, whereas the gene expression level of ANGPTL8 showed over a 5-fold increase. Similarly, the UCP1 gene expression was also significantly increased in SAT. Additionally, protein overexpression of ANGPTL8 was further confirmed by immunohistochemistry after extended cold treatment. Conclusion Our data shows that ANGPTL proteins are inhibited in the liver and BAT under cold treatment. This agrees with other studies that showed that reduction in ANGPTL4 in BAT improved thermogenesis in response to acute cold exposure. However, in our study we also observed that ANGPTL8 is activated under these conditions in SAT. This suggests that it might be involved in the regulation of lipolysis as well as enhancing SAT browning.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Increased expression level of ANGPTL8 in White Adipose tissue under Chronic Cold Treatment

Arefanian

Al-Khairi

Khalaf

et al. 2021

Preprint

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“…Moreover, it has been observed that curcumin could significantly suppress adipogenic differentiation of human bone marrow mesenchymal stem cells, in a concentrationdependent manner, by decreasing mRNA and protein expression levels of Kruppel-like factor 15 (119). Promotion of brown adipose tissue (BAT)-mediated thermogenesis has been proposed as a possible therapeutic strategy against obesity (120). Recently, Song and collaborators (2018) reported C o p y r i g h t E d r a S .…”

Section: Effects On Body Weight and Obesitymentioning

confidence: 99%

The pharmacological basis of the curcumin nutraceutical uses: an update

Canistro¹,

Chiavaroli²,

Cicia³

et al. 2021

Pharm Adv

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Curcumin is the major phytoconstituent found in the rhizomes of Curcuma longa L. Preparations derived from the rhizome of the plant, referred as turmeric, have been used for centuries in the traditional Indian system of medicine. The recent literature has shown curcumin as one of the most interesting pleiotropic nutraceuticals capable of interacting with different molecular targets involved in chronic diseases. The present review summarizes and critically discusses the very recent literature published between 2018 and 2021. We focused on the preclinical pharmacological actions of curcumin in relation to its possible clinical application in several pathophysiological states and disturbances including inflammation and pain, as well as metabolic, cardiovascular, dermatological, and central nervous system diseases. The most relevant molecular targets of curcumin, such as transcription factors, pro-inflammatory mediators, enzymes, and protein kinase as well as pharmacokinetics in humans are also reviewed.

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Deciphering adipose development: Function, differentiation and regulation

Guo,

Wang,

et al. 2024

Developmental Dynamics

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The overdevelopment of adipose tissues, accompanied by excess lipid accumulation and energy storage, leads to adipose deposition and obesity. With the increasing incidence of obesity in recent years, obesity is becoming a major risk factor for human health, causing various relevant diseases (including hypertension, diabetes, osteoarthritis and cancers). Therefore, it is of significance to antagonize obesity to reduce the risk of obesity‐related diseases. Excess lipid accumulation in adipose tissues is mediated by adipocyte hypertrophy (expansion of pre‐existing adipocytes) or hyperplasia (increase of newly‐formed adipocytes). It is necessary to prevent excessive accumulation of adipose tissues by controlling adipose development. Adipogenesis is exquisitely regulated by many factors in vivo and in vitro, including hormones, cytokines, gender and dietary components. The present review has concluded a comprehensive understanding of adipose development including its origin, classification, distribution, function, differentiation and molecular mechanisms underlying adipogenesis, which may provide potential therapeutic strategies for harnessing obesity without impairing adipose tissue function.

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Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus

Cited by 221 publications

References 156 publications

Increased expression level of ANGPTL8 in White Adipose tissue under Chronic Cold Treatment

Increased expression level of ANGPTL8 in White Adipose tissue under Chronic Cold Treatment

The pharmacological basis of the curcumin nutraceutical uses: an update

Deciphering adipose development: Function, differentiation and regulation

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