Brown Alga <i>Ecklonia cava</i> Polyphenol Extract Ameliorates Hepatic Lipogenesis, Oxidative Stress, and Inflammation by Activation of AMPK and SIRT1 in High-Fat Diet-Induced Obese Mice

Eo, Hyeyoon; Jeon, You‐Jin; Lee, Myoungsook; Lim, Yunsook

doi:10.1021/jf502830b

Cited by 82 publications

(75 citation statements)

References 46 publications

(90 reference statements)

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“…This capacity has been observed by both using pure phenolic compounds, such as resveratrol , oleuropein , and myricetin , as well as some precursors or derivatives of phenols, such as polydatin and KMU‐3 (a synthetic derivative obtained from gallic acid). In addition, some polyphenolic‐rich extracts, obtained from natural sources such as pecans , brown algae , and peach and plum juices , have shown the same behavior. Among all of these studies carried out with phenolic compounds, it is worthwhile to highlight that some of them have been conducted in humans.…”

Section: Food Compounds Useful For Counteracting Leptin Resistancementioning

confidence: 94%

Modulation of leptin resistance by food compounds

Aragonès

Ardid-Ruiz

Ibars

et al. 2016

Molecular Nutrition Food Res

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Leptin is mainly secreted by white adipose tissue and regulates energy homeostasis by inhibiting food intake and stimulating energy expenditure through its action in neuronal circuits in the brain, particularly in the hypothalamus. However, hyperleptinemia coexists with the loss of responsiveness to leptin in common obese conditions. This phenomenon has been defined as leptin resistance and the restoration of leptin sensitivity is considered to be a useful strategy to treat obesity. This review summarizes the existing literature on potentially valuable nutrients and food components to reverse leptin resistance. Notably, several food compounds, such as teasaponins, resveratrol, celastrol, caffeine, and taurine among others, are able to restore the leptin signaling in neurons by overexpressing anorexigenic peptides (proopiomelanocortin) and/or repressing orexigenic peptides (neuropeptide Y/agouti-related peptide), thus decreasing food intake. Additionally, some nutrients, such as vitamins A and D, can improve leptin transport through the blood-brain barrier. Therefore, food components can improve leptin resistance by acting at different levels of the leptin pathway; moreover, some compounds are able to target more than one feature of leptin resistance. However, systematic studies are necessary to define the actual effectiveness of each compound.

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Section: Food Compounds Useful For Counteracting Leptin Resistancementioning

confidence: 94%

Modulation of leptin resistance by food compounds

Aragonès

Ardid-Ruiz

Ibars

et al. 2016

Molecular Nutrition Food Res

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“…The extract of E. cava , a brown alga, has potential as a therapeutic agent for diabetes, evidenced by several previous studies [10,12,13,32] and its effects on reducing blood glucose levels in HFD-induced diabetic mice [12,13]. The therapeutic effect of E. cava extract in diabetic models might be, at least in part, due to the effect of phloroglucinol, which is a major component of E. cava extract.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Phloroglucinol, A Component of Ecklonia cava Extract, on Hepatic Glucose Production

2017

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Phloroglucinol is a phenolic compound that is one of the major compounds in Ecklonia cava (brown alga). It has many pharmacological activities, but its anti-diabetic effect is not yet fully explored. In this study, we investigated the effect of phloroglucinol on the control of blood glucose levels and the regulation of hepatic glucose production. Phloroglucinol significantly improved glucose tolerance in male C57BL/6J mice fed a high fat diet (HFD) and inhibited glucose production in mouse primary hepatocytes. The expression of phosphoenol pyruvate carboxykinase (PEPCK) and glucose-6-phosphatase mRNA and protein (G6Pase), enzymes involved in gluconeogenesis, were inhibited in liver tissue from phloroglucinol-treated mice and in phloroglucinol-treated HepG2 cells. In addition, phloroglucinol treatment increased phosphorylated AMP-activated protein kinase (AMPK)α in HepG2 cells. Treatment with compound C, an AMPKα inhibitor, inhibited the increase of phosphorylated AMPKα and the decrease of PEPCK and G6Pase expression caused by phloroglucinol treatment. We conclude that phloroglucinol may inhibit hepatic gluconeogenesis via modulating the AMPKα signaling pathway, and thus lower blood glucose levels.

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“…This extract has been shown to ameliorate insulin resistance, glucose tolerance and lipid metabolism in a high-fat diet (HFD)-induced obesity model in mice. Different mechanisms seem to be involved in these beneficial effects, involving the down-regulation of the obesity-associated inflammatory response due to the well-reported antioxidant properties, which result in the activation of AMP-activated protein kinase (AMPK) and the regulation of its downstream genes [97,98,99] (Figure 5). The AMPK is considered a key metabolic modulator; the activity of AMPK is compromised in diabetes, as this activity is regulated by the drugs currently used in human therapy as antidiabetics, such as metformin [100].…”

Section: Obesity and Diabetesmentioning

confidence: 99%

Potential Role of Seaweed Polyphenols in Cardiovascular-Associated Disorders

et al. 2018

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The beneficial effects of various polyphenols with plant origins on different cardiovascular-associated disorders, such as hypertension, diabetes mellitus type 2 and metabolic syndrome are well known. Recently, marine crude-drugs are emerging as potential treatments in many noncommunicable conditions, including those involving the cardiovascular system. Among the active compounds responsible for these activities, seaweed polyphenols seem to play a key role. The aim of the present review is to summarise the current knowledge about the beneficial effects reported for edible seaweed polyphenols in the amelioration of these prevalent conditions, focusing on both preclinical and clinical studies. This review will help to establish the basis for future studies in this promising field.

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Brown Alga Ecklonia cava Polyphenol Extract Ameliorates Hepatic Lipogenesis, Oxidative Stress, and Inflammation by Activation of AMPK and SIRT1 in High-Fat Diet-Induced Obese Mice

Cited by 82 publications

References 46 publications

Modulation of leptin resistance by food compounds

Modulation of leptin resistance by food compounds

The Effect of Phloroglucinol, A Component of Ecklonia cava Extract, on Hepatic Glucose Production

Potential Role of Seaweed Polyphenols in Cardiovascular-Associated Disorders

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