Potential Role of Seaweed Polyphenols in Cardiovascular-Associated Disorders

Gómez-Guzmán, Manuel; Rodríguez-Nogales, Alba; Algieri, Francesca; Gálvez, Júlio

doi:10.3390/md16080250

Cited by 126 publications

(110 citation statements)

References 132 publications

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“…Ecklonia cava is a marine brown alga that belongs to the family Lessoniaceae which has been used to conduct the human studies as it provides strong evidence of in vitro and in vivo antidiabetic potential. A clinical trial conducted by Guzman et al [59] found that the dieckol extract of brown alga Ecklonia cava has ability to reduce the postprandial blood glucose level significantly. In addition, Shin et al [60] found that the phlorotannins extracted from E. cava exhibited strong antioxidant potential which helps to reduce the oxidative stress-induced complications of diabetes.…”

Section: Effect Of Marine Brown Algae On Patients With Type 2 Dmmentioning

confidence: 99%

Antidiabetic Potential of Marine Brown Algae—a Mini Review

Gunathilaka

Samarakoon²,

Ranasinghe

et al. 2020

Journal of Diabetes Research

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Marine algae are an important source of bioactive metabolites in drug development and nutraceuticals. Diabetes mellitus is a metabolic disorder and the third leading cause of death worldwide due to lifestyle changes associated with rapid urbanization. Due to the adverse side effects of currently available antidiabetic drugs, search for an effective natural-based antidiabetic drug is important to combat diabetes and its complications. Therefore, in lieu with herbal drug development, it is important to find the potential benefits of seaweeds for the management of type 2 diabetes as they are underexplored yet in Sri Lanka. Among the marine seaweeds, natural bioactive compounds are abundant in brown algae with potentials in application as active ingredients in drug leads and nutraceuticals. Bioactive secondary metabolites are derived from numerous biosynthetic pathways of marine algae which contribute to various chemical and biological properties. Phlorotannins present in marine brown algae exhibited antidiabetic activities through different mechanisms such as the inhibitory effect of enzyme targets mainly by inhibiting the enzymes such as α-amylase, α-glucosidase, angiotensin-converting enzymes (ACE), aldose reductase, dipeptidyl peptidase-4, and protein tyrosine phosphatase 1B (PTP 1B) enzyme. In addition, phlorotannins derived from brown algae have the ability to reduce diabetic complications. Hence, the present review focuses on the different antidiabetic mechanisms of secondary bioactive compounds present in marine brown algae.

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Section: Effect Of Marine Brown Algae On Patients With Type 2 Dmmentioning

confidence: 99%

Antidiabetic Potential of Marine Brown Algae—a Mini Review

Gunathilaka

Samarakoon²,

Ranasinghe

et al. 2020

Journal of Diabetes Research

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“…These compounds vary from simple acids to more complex polyphenolic compounds. These compounds are great antioxidants and act as chelators of metals and free radicals, inhibiting lipid, and scavengers of Reactive Oxygen Species (ROS) like H 2 O 2 ; OH • ; O 2 •− & 1O 2 [ 6 ]. The phenolic and flavonoid contents of red seaweed from the Alexandria coast are significantly correlated to their DPPH antioxidant ability [ 2 , 36 ].…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…The phenolic and flavonoid contents of red seaweed from the Alexandria coast are significantly correlated to their DPPH antioxidant ability [ 2 , 36 ]. The antioxidant potency of macroalgal phenolic compounds counteracts the deleterious impacts of the advanced glycation end products (AGEs), which are the toxic effects associated with hyperglycemia ( Figure 3 ) [ 6 ]. The red alga Symphyocladia latiuscula bromophenols had antioxidant efficiency [ 37 ].…”

Section: Antioxidant Activitymentioning

confidence: 99%

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Therapeutic Uses of Red Macroalgae

2020

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Red Seaweed “Rhodophyta” are an important group of macroalgae that include approximately 7000 species. They are a rich source of structurally diverse bioactive constituents, including protein, sulfated polysaccharides, pigments, polyunsaturated fatty acids, vitamins, minerals, and phenolic compounds with nutritional, medical, and industrial importance. Polysaccharides are the main components in the cell wall of red algae and represent about 40–50% of the dry weight, which are extensively utilized in industry and pharmaceutical compounds, due to their thickening and gelling properties. The hydrocolloids galactans carrageenans and agars are the main red seaweed cell wall polysaccharides, which had broad-spectrum therapeutic characters. Generally, the chemical contents of seaweed are different according to the algal species, growth stage, environment, and external conditions, e.g., the temperature of the water, light intensity, nutrient concentrations in the ecosystem. Economically, they can be recommended as a substitute source for natural ingredients that contribute to a broad range of bioactivities like cancer therapy, anti-inflammatory agents, and acetylcholinesterase inhibitory. This review touches on the main points of the pharmaceutical applications of red seaweed, as well as the exploitation of their specific compounds and secondary metabolites with vital roles.

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“…The wide diversity of marine organisms is being recognized as a rich source of functional materials and, in 2015, the global seaweed aquaculture production reached 30 million tons [1]. Although marine algae have gained increasing attention over the last years due to the fact of their bioactive natural substances with potential health benefits, they are still identified as an underexploited resource [2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Quantification of Polyphenols in Seaweeds: A Case Study of Ulva intestinalis

et al. 2019

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In this case study, we explored quantitative 1H NMR (qNMR), HPLC-DAD, and the Folin-Ciocalteu assay (TPC) as methods of quantifying the total phenolic content of a green macroalga, Ulva intestinalis, after optimized accelerated solvent extraction. Tentative qualitative data was also acquired after multiple steps of purification. The observed polyphenolic profile was complex with low individual concentrations. The qNMR method yielded 5.5% (DW) polyphenols in the crude extract, whereas HPLC-DAD and TPC assay yielded 1.1% (DW) and 0.4% (DW) respectively, using gallic acid as the reference in all methods. Based on the LC-MS observations of extracts and fractions, an average molar mass of 330 g/mol and an average of 4 aromatic hydrogens in each spin system was chosen for optimized qNMR calculations. Compared to the parallel numbers using gallic acid as the standard (170 g/mol, 2 aromatic H), the optimized parameters resulted in a similar qNMR result (5.3%, DW). The different results for the different methods highlight the difficulties with total polyphenolic quantification. All of the methods contain assumptions and uncertainties, and for complex samples with lower concentrations, this will be of special importance. Thus, further optimization of the extraction, identification, and quantification of polyphenols in marine algae must be researched.

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Potential Role of Seaweed Polyphenols in Cardiovascular-Associated Disorders

Cited by 126 publications

References 132 publications

Antidiabetic Potential of Marine Brown Algae—a Mini Review

Antidiabetic Potential of Marine Brown Algae—a Mini Review

Therapeutic Uses of Red Macroalgae

Quantification of Polyphenols in Seaweeds: A Case Study of Ulva intestinalis

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