Brothers and sisters of childhood acute leukemia survivors: Their long‐term quality of life and its determinants

Faust, Cindy; Auquier, Pascal; Hamidou, Zeinab; Bertrand, Yves; Tabone, Marie‐Dominique; Ansoborlo, Sophie; Baruchel, André; Gandemer, Virginie; Dalle, Jean‐Hugues; Chastagner, Pascal; Kanold, Justyna; Poirée, Maryline; Sirvent, Nicolas; Plat, Geneviève; Pellier, Isabelle; Gautier, Michel; Berbis, Julie

doi:10.1002/cam4.5355

Cited by 6 publications

(10 citation statements)

References 42 publications

(71 reference statements)

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“…This substantiates existing literature on adult siblings that described similar or better HRQoL in siblings compared to references, but the studies either have methodological limitations such as using unvalidated measures or poorly defined samples 7,27,28 or were less long‐term after diagnosis 29,30 . Our outcomes do differ from a recent study that shows lower mental QoL in siblings compared to the general population 8 . However, the population is not comparable since siblings in their sample were different in terms of age, CCS diagnosis and time since diagnosis.…”

Section: Discussionsupporting

confidence: 84%

“…A systematic review shows that emotional and behavioral functioning of adult siblings was similar to references and states that methodological limitations hamper conclusions about health related quality of life (HRQoL) 7 . A more recent study shows lower mental HRQoL in adult siblings than in peers 8 . Regarding post‐traumatic stress, adult siblings do not experience more symptoms than controls 9 .…”

Section: Introductionmentioning

confidence: 68%

“…34 Apart from an association of small to medium size between siblings of CNS CCS and pain, we found no associations between the outcomes and cancer-related factors, which is substantiated in literature. 8,11,35 Following these results, factors that impact long-term psychosocial functioning of siblings of CCS might not differ from factors that impact the functioning of the general population.…”

Section: Associated Factorsmentioning

confidence: 77%

“…29,30 Our outcomes do differ from a recent study that shows lower mental QoL in siblings compared to the general population. 8 However, the population is not comparable since siblings in their sample were different in terms of age, CCS diagnosis and time since diagnosis. Siblings had similar anxiety and less depression compared to references, which is consistent with literature.…”

Section: Discussionmentioning

confidence: 99%

“…7 A more recent study shows lower mental HRQoL in adult siblings than in peers. 8 Regarding post-traumatic stress, adult siblings do not experience more symptoms than controls. 9 Besides generic outcomes such as HRQoL, disease-specific outcomes such as benefits and burden of having a brother of sister with cancer may be relevant.…”

Section: Introductionmentioning

confidence: 98%

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Psychosocial functioning of adult siblings of Dutch very long‐term survivors of childhood cancer: DCCSS‐LATER 2 psycho‐oncology study

et al. 2023

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ObjectiveTo describe psychosocial outcomes among adult siblings of very long‐term childhood cancer survivors (CCS), to compare these outcomes to reference populations and to identify factors associated with siblings' psychosocial outcomes.MethodsSiblings of survivors (diagnosed <18 years old, between 1963 and 2001, >5 years since diagnosis) of the Dutch Childhood Cancer Survivor Study DCCSS‐LATER cohort were invited to complete questionnaires on HRQoL (TNO‐AZL Questionnaire for Adult's HRQoL), anxiety/depression (Hospital Anxiety and Depression Scale), post‐traumatic stress (Self‐Rating Scale for Post‐traumatic Stress Disorder), self‐esteem (Rosenberg Self‐Esteem Scale) and benefit and burden (Benefit and Burden Scale for Children). Outcomes were compared to a reference group if available, using Mann‐Whitney U and chi‐Square tests. Associations of siblings' sociodemographic and CCS’ cancer‐related characteristics with the outcomes were assessed with mixed model analysis.ResultsFive hundred five siblings (response rate 34%, 64% female, mean age 37.5, mean time since diagnosis 29.5) of 412 CCS participated. Siblings had comparable HRQoL, anxiety and self‐esteem to references with no or small differences (r = 0.08−0.15, p < 0.05) and less depression. Proportions of symptomatic PTSD were very small (0.4%−0.6%). Effect sizes of associations of siblings' sociodemographic and CCS cancer‐related characteristics were mostly small to medium (β = 0.19−0.67, p < 0.05) and no clear trend was found in the studied associated factors for worse outcomes.ConclusionsOn the very long‐term, siblings do not have impaired psychosocial functioning compared to references. Cancer‐related factors seem not to impact siblings' psychosocial functioning. Early support and education remain essential to prevent long‐term consequences.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 68%

Section: Associated Factorsmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Psychosocial functioning of adult siblings of Dutch very long‐term survivors of childhood cancer: DCCSS‐LATER 2 psycho‐oncology study

et al. 2023

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Brothers and sisters of childhood acute leukemia survivors: Their long‐term quality of life and its determinants

et al. 2022

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Educational outcomes in siblings of childhood leukemia survivors: Factors associated with school difficulties and comparison with general population

Faust,

Auquier,

Gandemer

et al. 2024

Cancer Medicine

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BackgroundTo investigate the educational outcomes of siblings of childhood leukemia survivors, explore determinants of school difficulties, and compare the rates of repeating grades between siblings and the general population.MethodsA cross‐sectional study of childhood leukemia survivors' siblings recruited through the Leucémies de l'Enfant et de l'Adolescent cohort, a French long‐term follow‐up program, was conducted, and education‐related data were obtained via self‐report questionnaires. Adjusted logistic regression models were used to identify variables associated with school difficulties and time since diagnosis. Rates of repeating a grade in middle school were compared between siblings and the general population of the same generation.ResultsA total of 564 siblings with a mean time from diagnosis of 14.1 ± 6.4 years were included, among whom 139 (24.6%) repeated a grade, at an average of 6.4 ± 4.5 years after diagnosis. In multivariate analysis, the risk factors for repeating a grade were older siblings (odds ratio [OR] 2.3, p = 0.006), family financial difficulties (OR 2.8, p = 0.008), and history of repetition in survivors (OR, 2.5, p = 0.001). Sibling hematopoietic stem cell donors were at greater risk of repeating a grade long‐term after diagnosis (p = 0.018). Overall, siblings did not have a higher risk of educational delays at the end of middle school than the general population.ConclusionAlthough the results are reassuring, socioeconomic and cancer‐related factors may have an impact on siblings' schooling long after diagnosis. Paying attention to siblings contributes to identifying the most vulnerable families, allowing more attention and appropriate resources to avoid long‐term repercussions. Additionally, supportive and targeted interventions can be developed to improve the organization of education and the health care system.

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Brothers and sisters of childhood acute leukemia survivors: Their long‐term quality of life and its determinants

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 6 publications

References 42 publications

Psychosocial functioning of adult siblings of Dutch very long‐term survivors of childhood cancer: DCCSS‐LATER 2 psycho‐oncology study

Psychosocial functioning of adult siblings of Dutch very long‐term survivors of childhood cancer: DCCSS‐LATER 2 psycho‐oncology study

Brothers and sisters of childhood acute leukemia survivors: Their long‐term quality of life and its determinants

Educational outcomes in siblings of childhood leukemia survivors: Factors associated with school difficulties and comparison with general population

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