Brood and Size Dependent Variation in Susceptibility of Rainbow Trout, Oncorhynchus mykiss to Artificial Infection of Infectious Hematopoietic Necrosis Virus(IHNV).

Kasai, Kazuhiko; Yonezawa, Junji; Ono, Atsushi; Hasegawa, Atsuko; Honma, Tomoharu; Fukuda, Hideo

doi:10.3147/jsfp.28.35

Cited by 9 publications

(3 citation statements)

References 5 publications

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“…Susceptibility of the unvaccinated hosts was very homogenous relative to those vaccinated. Rainbow trout lines used in this experiment have been selectively bred for disease resistance, among other traits, due to the importance of IHNV in disease outbreaks in aquaculture ( 42 , 59 , 60 ). It is possible that selective breeding may have contributed to decreased variation in susceptibility if hosts with lower susceptibility were selected from a population with greater variance.…”

Section: Discussionmentioning

confidence: 99%

Vaccine Effects on Heterogeneity in Susceptibility and Implications for Population Health Management

Langwig

Wargo

Jones

et al. 2017

mBio

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Heterogeneity in host susceptibility is a key determinant of infectious disease dynamics but is rarely accounted for in assessment of disease control measures. Understanding how susceptibility is distributed in populations, and how control measures change this distribution, is integral to predicting the course of epidemics with and without interventions. Using multiple experimental and modeling approaches, we show that rainbow trout have relatively homogeneous susceptibility to infection with infectious hematopoietic necrosis virus and that vaccination increases heterogeneity in susceptibility in a nearly all-or-nothing fashion. In a simple transmission model with an R0 of 2, the highly heterogeneous vaccine protection would cause a 35 percentage-point reduction in outbreak size over an intervention inducing homogenous protection at the same mean level. More broadly, these findings provide validation of methodology that can help to reduce biases in predictions of vaccine impact in natural settings and provide insight into how vaccination shapes population susceptibility.

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Section: Discussionmentioning

confidence: 99%

Vaccine Effects on Heterogeneity in Susceptibility and Implications for Population Health Management

Langwig

Wargo

Jones

et al. 2017

mBio

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“…The average mortality of fry (progeny of 16 families of sockeye salmon generated by individual pair matings) challenged with IHNV ranged from 52 to 98%; their susceptibility was suggested to be based on genetic differences [ 52 ]. In a similar study of rainbow trout from 22 different families (bath challenged with IHNV), mortality ranged from 65 to 100% in 1 g fish, from 33 to 90% in 8 g fish and 10–85% in 25 g fish [ 53 ]. Chinook salmon strains from Washington State were more susceptible at fry stage than strains from Alaska [ 54 ].…”

Section: Exposed Host Population Susceptibility Parametersmentioning

confidence: 99%

Epidemiological characteristics of infectious hematopoietic necrosis virus (IHNV): a review

Dixon

Paley

Alegría-Morán

et al. 2016

Vet Res

130

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Infectious hematopoietic necrosis virus (IHNV, Rhabdoviridae), is the causative agent of infectious hematopoietic necrosis (IHN), a disease notifiable to the World Organisation for Animal Health, and various countries and trading areas (including the European Union). IHNV is an economically important pathogen causing clinical disease and mortalities in a wide variety of salmonid species, including the main salmonid species produced in aquaculture, Atlantic salmon (Salmo salar) and rainbow trout (Oncorhynchus mykiss). We reviewed the scientific literature on IHNV on a range of topics, including geographic distribution; host range; conditions required for infection and clinical disease; minimum infectious dose; subclinical infection; shedding of virus by infected fish; transmission via eggs; diagnostic tests; pathogen load and survival of IHNV in host tissues. This information is required for a range of purposes including import risk assessments; parameterisation of disease models; for surveillance planning; and evaluation of the chances of eradication of the pathogen to name just a few. The review focuses on issues that are of relevance for the European context, but many of the data summarised have relevance to IHN globally. Examples for application of the information is presented and data gaps highlighted.Electronic supplementary materialThe online version of this article (doi:10.1186/s13567-016-0341-1) contains supplementary material, which is available to authorized users.

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“…McIntyre and Amend (1978) reported that the heritability of resistance to IHNV was about 30%. Family level differences in IHNV susceptibility have also been observed in rainbow trout (Yamamoto et al 1991;Kasai et al 1993;author's unpublished data).…”

Section: Strain Of Salmonid Fishmentioning

confidence: 82%

Factors Affecting Pathogenicity of Infectious Hematopoietic Necrosis Virus (IHNV) for Salmonid Fish

LaPatra

1998

Journal of Aquatic Animal Health

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Pathogen is defined as any organism capable of causing disease whereas pathogenicity is the ability of an organism to produce disease. In this context, disease is a definitive morbid process having a characteristic set of symptoms. Furthermore, disease may affect the whole organism or any of its component cells or tissues. Regardless of the etiology, disease may either be clinically apparent or subclinical; and the outcome is dependent on the pathogen, the properties of the host, and the environment where they reside. For example, the virulence of infectious hematopoietic necrosis virus (IHNV) may vary with the age, species, and life stage of salmonid fish and water quality parameters including temperature. This review describes factors affecting the virulence of IHNV for salmonid fish and how these factors are involved in the host-pathogenenvironment interaction that determines occurrence of disease.

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Brood and Size Dependent Variation in Susceptibility of Rainbow Trout, Oncorhynchus mykiss to Artificial Infection of Infectious Hematopoietic Necrosis Virus(IHNV).

Cited by 9 publications

References 5 publications

Vaccine Effects on Heterogeneity in Susceptibility and Implications for Population Health Management

Vaccine Effects on Heterogeneity in Susceptibility and Implications for Population Health Management

Epidemiological characteristics of infectious hematopoietic necrosis virus (IHNV): a review

Factors Affecting Pathogenicity of Infectious Hematopoietic Necrosis Virus (IHNV) for Salmonid Fish

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