Brønsted Acid Promoted N‐Dealkylation of N‐Alkyl(sulfon)amides

Abstract

A simple and efficient Brønsted-acid-promoted N-dealkylation of N-alkylamides and N-alkylsulfonamides has been developed. This strategy features an ample substrate scope with excellent chemical selectivity, affording primary (sulfon)amide derivatives in moderate to good yields without the need for transitionmetal catalysts.

Carbamoylarylation of Alkenes with N-Aryl Oxamic Acids Involving 1,4-Aryl Migration Via C(aryl)–N Bond Cleavage

“…The removal of the tert -butyl group from the nitrogen atom is demonstrated in Scheme . The reactions of 3ha and 3aa using Sc­(OTf) 3 afford the corresponding arylpropanamides 6 and 7 in 76 and 72% yields, respectively …”