Several important improvements have been made in recent Moderate Resolution ImagingSpectroradiometer (MODIS) Collection 6 aerosol retrievals, but few regional validations are conducted. We compared Deep Blue (DB) and Dark Target (DT) retrievals over China and evaluated their performance with ground observations. Sampling frequency of DB was much higher than that of DT, which was mainly caused by unavailable retrieval of DT in bright surface and heavy pollution conditions. It is found that merged aerosol optical depth (AOD) will miss some cases if it was determined only by vegetation density. Collocated comparison shows that DT AOD was substantially higher than DB with seasonal difference exceeding 0.3-0.4 over eastern China. However, when all available retrievals were considered, DT AOD was obviously lower than DB in all the seasons except spring due to their large difference in spatial coverage in high-AOD conditions. DB can well reveal spatial extent of the widespread haze pollution while there were few values in DT. More than one half of the situations with AOD > 1.0 was missed by DT, which largely underestimated the common regional haze pollution in eastern China. Ground validations show that DT tended to overestimate the aerosol loading by underestimation of the surface contribution and single scattering albedo of aerosols. DB performed generally well with higher accuracy in northern China but exhibited obvious underestimation in northwestern and southern China. Despite of slight decrease in accuracy, DB retrievals with all quality enable a large increase in spatial coverage, especially when dense haze clouds existed.
Converging evidence increasingly implicates shared etiologic and pathophysiological characteristics among major psychiatric disorders (MPDs), such as schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD). Examining the neurobiology of the psychotic-affective spectrum may greatly advance biological determination of psychiatric diagnosis, which is critical for the development of more effective treatments. In this study, ensemble clustering was developed to identify subtypes within a trans-diagnostic sample of MPDs. Whole brain amplitude of low-frequency fluctuations (ALFF) was used to extract the low-dimensional features for clustering in a total of 944 participants: 581 psychiatric patients (193 with SZ, 171 with BD, and 217 with MDD) and 363 healthy controls (HC). We identified two subtypes with differentiating patterns of functional imbalance between frontal and posterior brain regions, as compared to HC: (1) Archetypal MPDs (60% of MPDs) had increased frontal and decreased posterior ALFF, and decreased cortical thickness and white matter integrity in multiple brain regions that were associated with increased polygenic risk scores and enriched risk gene expression in brain tissues; (2) Atypical MPDs (40% of MPDs) had decreased frontal and increased posterior ALFF with no associated alterations in validity measures. Medicated Archetypal MPDs had lower symptom severity than their unmedicated counterparts; whereas medicated and unmedicated Atypical MPDs had no differences in symptom scores. Our findings suggest that frontal versus posterior functional imbalance as measured by ALFF is a novel putative trans-diagnostic biomarker differentiating subtypes of MPDs that could have implications for precision medicine.
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