Bronchopulmonary leiomyosarcoma and fibrosarcoma. A study of 32 cases and review of the literature

Guccion, John G.; Rosen, Samuel H.

doi:10.1002/1097-0142(197209)30:3<836::aid-cncr2820300335>3.0.co;2-c

Cited by 120 publications

(56 citation statements)

References 42 publications

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“…Primary pulmonary osteosarcoma is an extremely rare malignancy (1,2). To the best of our knowledge, 17 other cases of primary pulmonary osteosarcoma have been reported (Table 1) (1,(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16).…”

Section: Discussionmentioning

confidence: 99%

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Two Cases of Primary Pulmonary Osteosarcoma

Kadowaki

Hamada²,

Yokoyama³

et al. 2005

Intern. Med.

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Two cases of primary pulmonary osteosarcoma are presented. In both cases, chest computed tomography revealed a calcified pulmonary mass and technetium-99m methylene diphosphonate bone scintigraphy showed intense uptake in the pulmonary mass. Primary pulmonary osteosarcoma was suspected on the basis of these radiographic findings. Microscopic examination of tumor specimens obtained by needle biopsy revealed histologic features of osteosarcoma, and this diagnosis was confirmed by postmortem examination of a second specimen in each case. Radiographic and histopathological findings enabled us to diagnose primary pulmonary osteosarcoma, which is one of the rarest types of cancer. Key words: primary pulmonary osteosarcoma, calcified pulmonary mass, technetium-99m methylene diphosphonate bone scintigraphy, needle biopsy

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Section: Discussionmentioning

confidence: 99%

“…Primary pulmonary sarcoma is rare with an incidence of one sarcoma for every 500 carcinomas (1,2). Osteosarcoma is the rarest histologic type of primary pulmonary sarcoma (3).…”

Section: Introductionmentioning

confidence: 99%

Two Cases of Primary Pulmonary Osteosarcoma

Kadowaki

Hamada²,

Yokoyama³

et al. 2005

Intern. Med.

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“…18,23,26,32,34,50,68,79 A generous sampling (at least one section per centimeter of tumor diameter) and the use of ancillary techniques, such as electron microscopy and immunohistochemistry, can be necessary to disclose the epithelial nature of the tumor.…”

Section: 76mentioning

confidence: 99%

Pulmonary Carcinomas With Pleomorphic, Sarcomatoid, or Sarcomatous Elements

Rossi

Cavazza

Stürm

et al. 2003

The American Journal of Surgical Pathology

342

207

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We collected 75 primary pulmonary carcinomas with pleomorphic, sarcomatoid, or sarcomatous elements to better define their clinical, histologic, and immunohistochemical profile. The patient's age ranged from 42 to 81 years (mean 65 years), and the male-to-female ratio was 9.7:1. Sixty-nine patients (92%) were smokers. Cough and hemoptysis were the most frequent presenting symptoms. Fifty-nine patients (65%) died of disease: only stage significantly predicts overall survival (p ‫ס‬ 0.0273). Microscopically, based on the WHO criteria, 58 cases were classified as pleomorphic carcinoma (51 with an epithelial component, 7 composed exclusively of spindle and giant cells), 10 as spindle cell carcinoma, 3 as giant cell carcinoma, 3 as carcinosarcoma, and 1 as pulmonary blastoma. Immunohistochemically, in the tumors composed exclusively of spindle and/or giant cells, thyroid transcription factor-1 (TTF-1) and cytokeratin 7 were positive in 55% and 70% of the cases, respectively, whereas surfactant protein-A was always negative. In pleomorphic carcinomas with an epithelial component, cytokeratin 7, TTF-1, and surfactant protein-A were positive in the sarcomatoid component in 62.7%, 43.1%, and 5.9% of the cases, respectively, whereas they were always negative in the sarcomatous part of carcinosarcomas and blastoma. In the epithelial component of pleomorphic carcinomas, cytokeratin 7, TTF-1, and surfactant protein-A were positive in 76.4%, 58.8%, and 39.2% of the cases, respectively, whereas the same antibodies did not react with the epithelial component of carcinosarcomas; in the case of blastoma, the epithelial part of the tumor was positive for cytokeratin 7 and TTF-1, whereas it was negative for surfactant protein-A. Cytokeratin 20 was always negative. In our opinion, this study: 1) supports the metaplastic histogenetic theory for this group of tumors; 2) shows that cytokeratin 7 and TTF-1, but not surfactant protein-A, are useful immunohistochemical markers in this setting; 3) confirms that stage is at the moment the only significant prognostic parameter, as in conventional non-small cell lung carcinomas; and 4) shows that this group of tumors has a worse prognosis than conventional non-small cell lung carcinoma at surgically curable stages I, justifying their segregation as an independent histologic type in the WHO classification.

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“…This term was more useful, because of the tumor's favourable outcome, in spite of its morphology. A summary of the English-language reported cases is given in Table 1 (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14).…”

Section: Discussionmentioning

confidence: 99%

Congenital Peribronchial Myofibroblastic Tumor: A Case Report and Review of the Literature

Acikalin¹,

Gümürdülü²,

Bağır³

et al. 2013

Balkan Med J

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IntroductionCongenital peribronchial myofibroblastic tumor (CPMT) is a rare tumor of childhood that is thought to develop during the early weeks of intrauterine life. It is usually associated with hydrops fetalis and polyhydramnios, and can be detected during prenatal evaluation by ultrasonography. We have found 15 cases in the English-language clinical literature; six of these cases were reported as doing well at 3 months to 6.5 years after resection. In this report, we present the seventh surviving patient, with radiographic, gross, and microscopic features of the tumor, together with a review of the literature. Case ReportA 38 year-old female patient, gravida five, para two, abortus one (G5P2A1), at 35 weeks of gestation, was referred to the obstetrics department of our institute with polyhydramnios. She was married to a relative, a maternal cousin. Her first child had died 3 days after birth of unknown causes. Her second and third children are 17 and 15 years old, with no health problems. Her fourth pregnancy was a miscarriage at 21 weeks of gestation. An autopsy performed on this foetus had revealed omphalocele, olygodactyly of the left foot, and flexion deformity of the left hand.Our case was her fifth pregnancy. Prenatal ultrasonography at 35 weeks revealed polyhydramnios, hydrothorax, and a mass in the right lung. The male neonate was delivered by caesarean section at the 37 th gestational week. Birth weight was 3100 gr. The infant was cyanotic, and did not cry at birth; he required intubation and positive-pressure ventilation. Postnatal echocardiography revealed a mass in the right lung, hydrothorax, patent foramen ovale, and pulmonary hypertension. Postnatal computerised tomography showed a solid mass in the right lung, about 6 cm in diameter (Figure 1). Serum levels of alpha-fetoprotein (AFP) and neuron-specific enolase (NSE) were 15430 ng/mL (normal: 40-150 ng/mL) and 45.02 ng/mL (normal: 0-16.3 ng/mL), respectively.On day 12 after delivery, the neonate was extubated and was stable after surfactant therapy. A right middle lobectomy was performed by thoracotomy, during which a wellcircumscribed mass, originating from the right middle lobe, was found. Upper and lower lobes were quite normal, and a formal lobectomy was possible without any difficulty. No complications occurred in the postoperative period, and the infant breathed spontaneously. It has been 26 months since the surgery, and the patient is doing well, with no recurrence. Pathological FindingsThe mass removed at lobectomy was well circumscribed, with no true capsule, and was 6.5x5.5 cm in size (Figure 2). There was a small area of compressed lung tissue surrounding the mass. Its cut surface was solid and grey-tan, with necrotic areas at the centre.Microscopically, lung parenchyma was replaced by wellcircumscribed, non-encapsulated mesenchymal tumor (Figure 3). Tumor cells were uniformly spindle-shaped, with finely granular chromatin (Figure 4). There was no anaplasia or pleomorphism. Tumor cells were surrounding the bronchial walls, but not ...

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Bronchopulmonary leiomyosarcoma and fibrosarcoma. A study of 32 cases and review of the literature

Cited by 120 publications

References 42 publications

Two Cases of Primary Pulmonary Osteosarcoma

Two Cases of Primary Pulmonary Osteosarcoma

Pulmonary Carcinomas With Pleomorphic, Sarcomatoid, or Sarcomatous Elements

Congenital Peribronchial Myofibroblastic Tumor: A Case Report and Review of the Literature

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