Two Cases of Primary Pulmonary Osteosarcoma

Kadowaki, Toru; Hamada, Hironobu; Yokoyama, Akihito; Katayama, Hitoshi; Abe, Masahiro; Nishimura, Kazuhiko; Tomiyama, Noriyuki; Kito, Katsumi; Miyazaki, Tatsuhiko; Higaki, Jitsuo

doi:10.2169/internalmedicine.44.632

Cited by 23 publications

(20 citation statements)

References 15 publications

(20 reference statements)

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“…The patient was alive 42 months post pneumonectomy with extensive metastatic disease and morbidity. Lymph node metastasis is uncommon in this uncommon entity, with only 4 of the 21 reported cases having lymph node metastases [4][5][6][7], and only the aforementioned patient [4] received palliative radiotherapy. Loose [8] reported on a patient who received palliative radiotherapy for a resected brain metastasis and was alive 7 months after diagnosis with no evidence of disease.…”

Section: Discussionmentioning

confidence: 99%

A radio-sensitive primary osteosarcoma in the lung

et al. 2010

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We report an unusual case of a primary osteosarcoma of the lung in an asymptomatic 77-year-old male, who underwent lobectomy with complete resection of the lung lesion. His pattern of relapse was to multiple lymph nodes. The first relapse was 11 weeks after lobectomy in subcarinal lymph nodes, confirmed on needle aspiration to be consistent with sarcoma. Given his excellent performance status, this was treated with radical radiotherapy to 70 Gy in 35 fractions with good control. He relapsed to other lymph node regions. A biopsy of the external iliac lymph node was done and revealed osteoid production, consistent with osteosarcoma. He received palliative radiotherapy to several nodal areas with good clinical response. We review the literature of this rare tumor with an unusual pattern of relapse.

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Section: Discussionmentioning

confidence: 99%

A radio-sensitive primary osteosarcoma in the lung

et al. 2010

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“…Only 20 cases of primary osteosarcoma of the lung have previously been reported [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. We report the most recent case of primary osteosarcoma of the lung, which was diagnosed by computed tomography (CT)-guided needle biopsy, rapidly progressed, and was later confirmed by autopsy examination.…”

Section: Introductionmentioning

confidence: 99%

Primary osteosarcoma of the lung: a case report and review of the literature

et al. 2007

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Primary osteosarcoma of the lung is exceedingly rare. A 72-year-old man was admitted to our hospital; a primary osteosarcoma of the lung was diagnosed following computed tomography-guided needle biopsy. He died of rapidly progressing respiratory insufficiency without effective treatment seven months after the onset of symptoms. Macroscopic findings at autopsy showed typical histologic features of osteosarcoma without any bony lesion. Here we present a rare case and review the clinicopathological features of 20 previously reported cases.

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“…To explain this, three possibilities were considered as follows: The first possibility is that the tumor was a mixed carcinoma and sarcoma. Primary pulmonary osteosarcomas are generally extremely rare, with only a few cases reported in the literature to date (1)(2)(3)(4)(5). The origin of the carcinoma in most cases of primary pulmonary carcinosarcoma is non-SCLC (8).…”

Section: Discussionmentioning

confidence: 99%

“…Primary pulmonary osteosarcoma is a rare entity, with only a few cases reported in the literature to date (1)(2)(3)(4)(5). Miller et al (6) reported the incidence of primary pulmonary osteosarcoma as 0.01%.…”

Section: Introductionmentioning

confidence: 99%

Extraskeletal osteosarcoma of the lung following treatment of primary small‑cell lung carcinoma with chemoradiotherapy: A case report

et al. 2017

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Abstract. Primary pulmonary osteosarcoma is a rare entity, with only a few cases reported in the literature to date. Moreover, secondary extraskeletal osteosarcoma of the lung following chemoradiotherapy is extremely rare and, to the best of our knowledge, this is the first reported case. We herein present the case of an 80-year-old male patient with small-cell lung cancer (SCLC), who developed what it was initially considered as recurrence of the tumor after chemoradiotherapy. The patient eventually succumbed to the disease, and on autopsy it was discovered that the lung tumor was not in fact SCLC, but rather a secondary osteosarcoma. Osteosarcoma metastasis to the lung is very rare, but must be considered in the differential diagnosis when there is relapse following treatment for primary SCLC. IntroductionWe encountered a case of extraskeletal osteosarcoma of the lung following chemoradiotherapy for small-cell lung carcinoma (SCLC). Primary pulmonary osteosarcoma is a rare entity, with only a few cases reported in the literature to date (1-5). Miller et al (6) reported the incidence of primary pulmonary osteosarcoma as 0.01%. Niimi et al (7) reviewed the 20 cases of primary pulmonary osteosarcoma, and the age on onset was 33-81 years old, male/female ratio was 1:1 and the most common site was left lung. Most of patient died within a year on onset symptom. Moreover, secondary osteoskeletal osteosarcoma of the lung following chemoradiotherapy is extremely rare and, to the best of our knowledge, this is the first case reported to date. Case reportAn 80-year-old male patient had been diagnosed with SCLC of middle lower lobe of the right lung ( (Fig. 1B). However, the disease recurred locally 3 years later, and the patient was again admitted to our hospital for second-line chemotherapy. The patient's chest computed tomography (CT) scan revealed an oval-shaped tumor in the same region of the lung that had been previously affected (Fig. 1C). The lesion was not evaluated by pathological examination, as its location was the same as that at the initial diagnosis of SCLC, thus, it was considered to be a recurrence of the primary tumor and it was treated with carboplatin (AUC=4, 330 mg, Day 1) and irinotecan (CPT-11; 60 mg/m 2 , 100 mg, Day 1, 8 and 15) as second-line chemotherapy. As the cancer did not respond sufficiently to this treatment, third-line amrubicin hydrochloride (AMR; 30 mg/m 2 , 50 mg, Day 1-3) was administered. Unfortunately, the patient's performance status (PS) decreased, despite treatment. Chemotherapy was discontinued after the first cycle and followed by best supportive care (BSC). During the second hospitalization for second-and third-line chemotherapy, the patient developed a cerebral infarction, causing permanent paralysis in the lower half of his body.The patient was again admitted to our hospital after sustaining a second cerebral infarction. At that point, his PS was 4, and retention of the pleural effusion in the right thoracic cavity was detected. A chest tube was inserted to drain the fluid...

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Two Cases of Primary Pulmonary Osteosarcoma

Cited by 23 publications

References 15 publications

A radio-sensitive primary osteosarcoma in the lung

A radio-sensitive primary osteosarcoma in the lung

Primary osteosarcoma of the lung: a case report and review of the literature

Extraskeletal osteosarcoma of the lung following treatment of primary small‑cell lung carcinoma with chemoradiotherapy: A case report

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