BRONCHOPULMONARY INFECTION DUE TO Β-Lactamase-Producing BRANHAMELLA CATARRHALIS TREATED WITH AMOXYCILLIN/CLAVULANIC-ACID

Ninane, G; Joly, J; Kraytman, M; Piot, Peter

doi:10.1016/s0140-6736(78)91763-4

Cited by 57 publications

(21 citation statements)

References 4 publications

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“…It has been implicated in a wide variety of infectious processes (G. V. Doern, M. J. Miller, R. E. Winn, submitted for publication), including conjunctivitis, otitis media, sinusitis, endocarditis, meningitis, septicemia, and pneumonia, particularly in patients with underlying compromised pulmonary function. Although previously defined as being uniformly susceptible to penicillin (5), several recent studies demonstrated that clinically significant isolates of B. catarrhalis were resistant to penicillin by virtue of their ability to produce /3-lactamase (8,10,(12)(13)(14). Due to the paucity of reported clinical antibiotic trials and in vitro susceptibility studies, little additional information exists regarding the antimicrobial susceptibility of B. catarrhalis.…”

mentioning

confidence: 99%

Antibiotic Susceptibility of Beta-Lactamase-Producing Strains of Branhamella ( Neisseria ) catarrhalis

Doern¹,

Siebers

Hallick

et al. 1980

Antimicrob Agents Chemother

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confidence: 99%

Antibiotic Susceptibility of Beta-Lactamase-Producing Strains of Branhamella ( Neisseria ) catarrhalis

Doern¹,

Siebers

Hallick

et al. 1980

Antimicrob Agents Chemother

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“…302). Another report described the successful eradication of beta-lactamase-producing Branhamella catarrhalis from the transtracheal aspirates of three patients with exacerbation of their chronic bronchitis (7).…”

Section: Discussionmentioning

confidence: 99%

Clavulanic acid and penicillin treatment of Staphylococcus aureus renal infection in mice

Heerema¹,

Musher²,

Williams³

1979

Antimicrob Agents Chemother

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Clavulanic acid, an inhibitor of beta-lactamase, was used together with penicillin to treat infection caused by a penicillinase-producing Staphylococcus aureus. Clavulanic acid + penicillin administered to mice, prophylactically or in treatment of established infection, reduced morbidity, bacterial counts in the kidneys, and/or mortality; these differences were statistically significant when compared with those obtained by using penicillin or clavulanic acid alone.

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“…Clavulanic acid (CA) is a -lactam antibiotic produced by Streptomyces clavuligerus. It is clinically used as a wide-spectrum irreversible -lactamase inhibitor to treat various types of infections [1]. We recently reported a double-reporter guided mutant selection (dRGMS) method to generate CA over-producing mutants of S. clavuligerus [2].…”

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Development of a colorimetric assay for rapid quantitative measurement of clavulanic acid in microbial samples

Dai

Xiang

et al. 2012

Sci. China Life Sci.

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We developed a colorimetric assay to quantify clavulanic acid (CA) in culture broth of Streptomyces clavuligerus, to facilitate screening of a large number of S. clavuligerus mutants. The assay is based on a -lactamase-catalyzed reaction, in which the yellow substrate nitrocefin ( max =390 nm) is converted to a red product ( max =486 nm). Since CA can irreversibly inhibit -lactamase activity, the level of CA in a sample can be measured as a function of the A 390 /A 486 ratio in the assay mixture. The sensitivity and detection window of the assay were determined to be 50 g L 1 and 50 g L 1 to 10 mg L 1, respectively. The reliability of the assay was confirmed by comparing assay results with those obtained by HPLC. The assay was used to screen a pool of 65 S. clavuligerus mutants and was reliable for identifying CA over-producing mutants. Therefore, the assay saves time and labor in large-scale mutant screening and evaluation tasks. The detection window and the reliability of this assay are markedly better than those of previously reported CA assays. This assay method is suitable for high throughput screening of microbial samples and allows direct visual observation of CA levels on agar plates.

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BRONCHOPULMONARY INFECTION DUE TO Β-Lactamase-Producing BRANHAMELLA CATARRHALIS TREATED WITH AMOXYCILLIN/CLAVULANIC-ACID

Cited by 57 publications

References 4 publications

Antibiotic Susceptibility of Beta-Lactamase-Producing Strains of Branhamella ( Neisseria ) catarrhalis

Antibiotic Susceptibility of Beta-Lactamase-Producing Strains of Branhamella ( Neisseria ) catarrhalis

Clavulanic acid and penicillin treatment of Staphylococcus aureus renal infection in mice

Development of a colorimetric assay for rapid quantitative measurement of clavulanic acid in microbial samples

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