1997
DOI: 10.1111/j.1651-2227.1997.tb14897.x
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Bronchopulmonary dysplasia and oxidative stress: are we closer to an understanding of the pathogenesis of BPD?

Abstract: In recent years a body of data has accumulated, linking the development of bronchopulmonary dysplasia (BPD) to increased oxidative stress in the first few days after birth, since high concentrations of metabolites reflecting increased peroxidation products such as pentane, ethane, protein carbonyl, o-tyrosine, allantoin and F2-isoprostanes, as well as low levels of glutathione and sulfhydryl/total protein ratio, also reflecting increased oxidative load, have been found in the premature infants at risk of or de… Show more

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Cited by 119 publications
(60 citation statements)
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“…The animal model we used mimics some pathologic features of BPD, such as increased inflammation, fibrosis, and septal thickness; decreased RAC and alveolar formation. These results are consistent with previous reports that hyperoxia can induce lung injury and disrupt alveolar septation at the critical stages of lung development (30,31).…”
Section: Discussionsupporting
confidence: 83%
“…The animal model we used mimics some pathologic features of BPD, such as increased inflammation, fibrosis, and septal thickness; decreased RAC and alveolar formation. These results are consistent with previous reports that hyperoxia can induce lung injury and disrupt alveolar septation at the critical stages of lung development (30,31).…”
Section: Discussionsupporting
confidence: 83%
“…Artificial ventilation is causing damage with high peak inspiratory pressures and high percentage of inhaled oxygen, causing the formation of oxygen radicals. Beside GA, gender and PDA, resuscitation measures and mechanical ventilation high concentrations in tracheal aspirate fluid of infants developing BPD (38). Analysing prenatal and postnatal risk factors for BPD in our cohort of infants with GA < 30 wks, prenatal inflammation was not identified as a risk factor for BPD.…”
Section: Discussionmentioning
confidence: 92%
“…[20][21][22] El efecto de la hiperoxia a través de radicales libres en los prematuros se ve favorecido por una disminución de mecanismos antioxidantes en este grupo de niños. 3,20,21 El estudio aleatorizado SUPPORT comparó dos rangos de objetivos de saturación de oxígeno en prematuros menores de 28 semanas durante toda su internación. 23 Estos autores reportaron que, si bien el rango bajo (85-89%) disminuyó el riesgo de retinopatía del prematuro y DBP, se asoció a mayor mortalidad.…”
Section: Discussionunclassified